Bryan Bellaire
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Bryan Bellaire
Assistant Professor
Vet Microbiology & Preventive Medicine
(515) 294-1006
1136 Vet Med
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Expertise / Research Area
My research is focused on understanding the microbial and cellular events that take place during persistent bacterial infections. Avenues of investigation include the following; Bacterial Pathogenesis of Brucella spp. in swine, bovine, canine and human hosts; Translational Medicine associated with developing novel antimicrobial delivery platform that will target persistent intracellular pathogens; Biosafety and Biodefense: illuminating molecular interactions between the human host and virulent Biowarfare agents, Yersinia and Brucella spp..
Teaching
2006 - Present: Lecturer-Microbial Pathogenesis MICRO 553, VMPM 586 (ISU)
2006 - Present: Lecturer-Bacterial Pathogenesis: VMPM 528 (ISU)
2007 - Present: Lecturer-Innate Immunity in Bacterial Diseases: VMPM 625 (ISU)
2007 - Present: Course Co-Organizer VMPM 604 (ISU)
Education
1995 B.S. Microbiology, Northern Arizona University, Flagstaff, AZ.
2001 Ph.D. Bacterial Pathogenesis, Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, LA.
Selected Publications
Bellaire, B.H., C.L. Baldwin, P.H. Elzer and R.M. Roop II. 1999. The siderophore 2,3-dihydroxybenzoic acid is not required for virulence of Brucella abortus in BALB/c mice. Infect. Immun. 67: 2615-2618.
Parent, M.A., Bellaire, B.H., Murphy, E.A., R.M. Roop II, P.H. Elzer and C.L. Baldwin. 2002. Brucella abortus siderophore 2,3-dihydroxybenzoic acid (DHBA) facilitates intracellular survival of the bacteria. Microb. Pathog. 32(5): 239-248.
Bellaire, B.H., P.H. Elzer, S.D. Hagius, J.V. Walker, N.J. Booth, M.D. Edmonds, C.L. Baldwin, R. Freeland and R.M. Roop II. 2003. Genetic organization and iron-Responsive regulation of the Brucella abortus 2,3-dihydroxybenzoic acid biosynthesis operon, a cluster of genes required for wild-type virulence in pregnant cattle. Infect Immun. 71(4): 1794-1803.
Bellaire, B.H., P.H. Elzer, C.L. Baldwin, and R.M. Roop II. 2003. Production of the siderophore 2,3-dihydroxybenzoic acid is required for wild-type growth of Brucella abortus in the presence of erythritol under low iron conditions in vitro. Infect Immun. 71(5): 2927-832.
RoopII, R.M., B.H. Bellaire, E. Anderson and J.T. Paulley. 2004. Iron metabolism in Brucella, p. 243-262. In I. Lopez-Goni and I. Moriyon (ed.), Brucella: Molecular and cellular biology. Horizon Scientific Press.
Roop II, R.M., B.H. Bellaire, M.W. Valderas, and J.A. Cardelli. 2004. Adaptation of the brucellae to their intracellular niche. Mol. Micro. 52(3): 621-630.
Valderas, M.W., R.B. Alcantara, J.B. Baumgartner, B.H. Bellaire, G.T. Robertson, W.L. Ng, J.M. Richardson, M.E. Winkler, and R.M. Roop II. 2005. Role of HdeA in acid resistance and virulence in Brucella abortus 2308. Vet. Micro. 20;107(3-4): 307-12.
Bellaire, B.H., R.M. Roop II, J.A. Cardelli. 2005. Opsonized virulent Brucella abortus replicate within non-acidic, endoplasmic reticulum negative, LAMP 1 positive phagosomes in human monocytes. Infect. Immun. 73(6): 3702-3713.
B.C. Reed, C. Cefalu, B.H. Bellaire, J.A. Cardelli, T. Louis, J. Salamon, M.A. Bloecher and R.C. Bunn. 2005. GLUT1CBP(TIP2/GIPC1) Interactions with GLUT1 and Myosin VI: Evidence Supporting an Adapter Function for GLUT1CBP Mol. Bol. Cell. 16(9): 4183-4201.
Roux, C.M., N.J. Booth, B.H. Bellaire, J.M. Gee, R.M. Roop II, M.E. Kovach, R.M. Tsolis, P.H. Elzer and D.G. Ennis. 2006. RecA and RadA proteins of Brucella abortus do not perform overlapping protective DNA repair functions following oxidative burst. J. Bacteriol. 188(14): 5187-5195.
Snider, J.L, B.H. Bellaire and J.A. Cardelli. Both CagA-Dependent and –Independent Signaling Pathways Contribute to Helicobacter pylori – Induced Motility of Gastric Carcinoma Cells. J. Cell Biol. Accepted: Feb 2007.
Ulery BD, Phanse Y, Sinha A, Wannemuehler MJ, Narasimhan B, Bellaire BH. 2009. Polymer chemistry influences monocytic uptake of polyanhydride nanospheres. Pharm Res. Mar;26(3):683-90.
Leadership
1999-2000: Executive Council of the Student Body: Graduate Student Representative
1999-2000: Graduate Student Council: Dept. of Microbiology Student Representative
1999-2000: Graduate Advisory Council: Student Representative
2000-2006: LSUHSC BSL3 Laboratory Manager
2003-2006: Co-founder and President of LSUHSC Postdoctoral Organization
2003-2006: Scientific Advisory Board for LSUHSC Research Core Facility Microscopy Section
2004-2006: LSUHSC Institutional Biosafety Committee
2006-present: ISU VMPM-BSL3 Laboratory Director
Yersinia Project Consultant for BSL3 Select Agent Certification.
2007-present: ISU-CVM Biosafety Laboratory Consultant
2007-present: Ad hoc reviewer for Journal of Swine Health and Production.
5/15/2007 USDA Review Panelist. Animal Protection and Biosafety Section (44.0).
Honors & Awards
1994 Undergraduate Fellowship: Science and Engineering Research Semester Sponsored by the Department of Energy. January – May.
1997 Arnold Ravin – Murial Rogers Fellowship. 41st Annual Wind River Conference on Procaryotic Biology. June.
1998 The Donald E. Kahn Memorial Award for the Outstanding Graduate Student Presentation. 79th Annual Conference for Research Workers in Animal Diseases. November.
1998 Arnold Ravin – Murial Rogers Fellowship. 42nd Annual Wind River Conference on Procaryotic Biology. June.
1999 Arnold Ravin – Murial Rogers Fellowship. 43rd Annual Wind River Conference on Procaryotic Biology. June.
2000 Arnold Ravin – Muriel Rogers Fellowship. 44th Annual Wind River Conference on Procaryotic Biology. June.
2000 McCleskey Award for the Outstanding Graduate Student Presentation in
Bacteriology. South Central Branch American Society for Microbiology. November.
2001 Outstanding Postdoctoral Poster Presentation. Ray A. Barlow Scientific Symposium. January.
2002 Arnold Ravin – Murial Rogers Fellowship. 46th Annual Wind River Conference on Procaryotic Biology. June.
2002 Outstanding Postdoctoral Poster Presentation. Ray A. Barlow Scientific Symposium.
2003 Travel Award. 1st Annual Mid-Atlantic Microbial Pathogenesis Meeting, February 2-4. Wintergreen, Virginia.
2005 Outstanding Postdoctoral Presentation. Graduate Research Day. LSUHSC-Shreveport, May.
2006 Arnold Ravin – Murial Rogers Fellowship. 50th Annual Wind River Conference on Procaryotic Biology. June.
2009 Honorary Member of Phi Zeta Veterinary Honors Society
2009 – Present: Honorary Member of Phi Zeta Veterinary Honors Society
Memberships
1994 – 1995: Beta-Beta-Beta Biological Honor Society (Northern Arizona)
1994 – Present: American Society for Microbiology
1996 – 1999: Research Workers in Animal Diseases
1996 – 2006: South Central Branch of the American Society for Microbiology
1996 – Present: American Association for the Advancement of Science
2002 – Present: American Society for Cell Biology
2006 – 2008: Midwest Branch of the American Society for Microbiology
