Pre-harvest food safety, bacterial colonization mechanisms, zoonotic transmission of bacterial pathogens, pathogenesis of enteric E. coli diseases and the microbial ecology of gastrointestinal systems. Currently projects include defining colonization mechanisms used by E. coli O157:H7 in ruminants and understanding the pathogenesis of STEC disease using an edema disease model in piglets.

 Micro 553. Pathogenic microorganisms.   Fall, on campus; Alt. Spring, on-line. 1 credit.  Review and comparison/contrast of common bacterial pathogens of plants and animals and their mechanisms of virulence, including toxins, protein secretion, host invasion and iron acquisition strategies.  An overview of eukaryotic cell biology that is relevant to pathogenesis will also be included.

MS & PhD Microbiology,  Iowa State University

Cornick, NA, I Matise, JE Samuel, BT Bosworth and HW Moon. 2000. Shiga toxin-producing Escherichia coli infection: temporal and quantitative relationships among colonization, toxin production, and systemic disease. J. Infect. Dis. 181:242-251.

Cornick, NA, SL Booher, TA Casey and HW Moon. 2000. Persistent colonization of sheep by Escherichia coli O157:H7 and other E. coli pathotypes. Appl. Environ. Microbiol. 66:4926-4934.

Matise, I, NA Cornick, SL Booher, JE Samuel, BT Bosworth and HW Moon. 2001. Intervention with Stx antibody following infection by Shiga toxin-producing Escherichia coli. J. Infect. Dis. 183:347-50.

Cornick, NA, SL Booher and HW Moon. 2002. Intimin facilitates colonization by Escherichia coli O157:H7 in ruminants. Infect. Immun. 70:2704-2707.

Booher, SL, NA Cornick, and HW Moon. 2002. Persistence of Escherichia coli O157:H7 in swine. Vet. Microbiol. 89:69-81.

Matise, I, NA Cornick, JE Samuel, and HW Moon. 2003. Binding of Shiga toxin 2e to porcine erythrocytes in vivo and in vitro. Infect. Immun. 71:5194-5201.

Cornick, NA, and AF Helgerson. 2004. Transmission and infectious dose of E. coli O157:H7 for swine. Appl. Environ. Microbiol. 70:5331-5335.

Cornick, NA, AF Helgerson, V Mai, JM Ritchie, DWK Acheson. 2006. In vivo transduction of stx-encoding phage in ruminants. Appl. Environ. Microbiol. 72:5086-5088.

Helgerson, AF, V Sharma, AM Dow, R Schroeder, K Post and NA Cornick. 2006. Edema disease caused by a clone of Escherichia coli O147:H17. J. Clin. Microbiol. 44:3074-3077.

Cornick, NA, AF Helgerson and V Sharma. 2007. Stx-encoding phage does not facilitate colonization of Escherichia coli O157:H7 in sheep. Appl. Environ. Microbiol. 73:344-346.

Cutler, SA, SM Lonergan, NA Cornick, AK Johnson and CH Stahl. 2007. Dietary inclusion of colicin E1 is effective in preventing postweaning diarrhea caused by F18-positive Escherichia coli in pigs. Antimicrob. Agents and Chemother. 51:3830-3835.

VuKhac, H and NA Cornick. 2008. Prevalence and genetic profiles of Shiga toxin-producing Escherichia coli strains isolated from buffaloes, cattle and goats in central Viet Nam. Vet. Microbiol. 126:356-363.

Member, Interdept. Microbiol. Supervisory committee, 2006 – present

Chair, Institutional Biosafety Committee, 2006-present

Chair, Division Z – Amer. Society for Microbiology, 2007

American Society for Microbiology