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Recent Publications

Sun, F., Kanthasamy, A., Anantharam, V. and Kanthasamy, A. G., (2009). Mitochondrial accumulation of polyubiquitinated proteins and differential regulation of apoptosis by polyubiquitination sites Lys-48 and -63. J Cell Mol Med. 1582-4934 (Electronic)

Afeseh Ngwa, H., Kanthasamy, A., Anantharam, V., Song, C., Witte, T., Houk, R. and Kanthasamy, A. G., 2009. Vanadium induces dopaminergic neurotoxicity via protein kinase Cdelta dependent oxidative signaling mechanisms: relevance to etiopathogenesis of Parkinson's disease. Toxicol Appl Pharmacol. 240, 273-285.

Ortiz-Ortiz, M. A., Moran, J. M., Bravosanpedro, J. M., Gonzalez-Polo, R. A., Niso-Santano, M., Anantharam, V., Kanthasamy, A. G., Soler, G. and Fuentes, J. M., (2009). Curcumin enhances paraquat-induced apoptosis of N27 mesencephalic cells via the generation of reactive oxygen species. Neurotoxicology. 30(6):1008-18. Epub 2009 Aug 4.

Kanthasamy A, Jin H, Mehrotra S, Mishra R, Kanthasamy A, Rana A. (2009). Novel cell death signaling pathways in neurotoxicity models of dopaminergic degeneration: Relevance to oxidative stress and neuroinflammation in Parkinson's disease.  Neurotoxicology. 2009 Dec 11. [Epub ahead of print]

Yang, Y., Kanthasamy, A., Jin, H, Anantharam, V. and Kanthasamy, AG. (2008). Nuclear localization of PKC is regulated by proximity of the N-terminal C2-like domain and to the C-terminal nuclear localization signal. J. Biol. Chem.  In revision

Kanthasamy, A, Kitazawa, M, Yang, Y., Anantharam V. and Kanthasamy, AG. (2008) Environmental Neurotoxic chemical induces apoptosis in mesencephalic dopaminergic neuronal cells via caspase-3-dependent proteolytic activation of protein kinase Cd: Implications for molecular mechanisms of dopaminergic degeneration in Parkinson’s disease. BMC Molecular Brain. In press.

Carvour, V Song, C,  Kaul, S., Anantharam, V, Kanthasamy, AG,  Kanthasamy. A (2008) Chronic low dose oxidative stress induces caspase-3 dependent PKCd proteolytic activation and apoptosis in a cell culture model of dopaminergic neurodegeneration. Annals of the New York Academy of Sciences. In press.

Carvour, V Song, C,  Kaul, S., Anantharam, V, Kanthasamy, AG,  Kanthasamy. A (2008) Chronic low dose oxidative stress induces caspase-3 dependent PKCd proteolytic activation and apoptosis in a cell culture model of dopaminergic neurodegeneration. Annals of the New York Academy of Sciences. In press.

Xu Q, Kanthasamy AG, Reddy MB. (2008). Neuroprotective effect of the natural iron chelator, phytic acid in a cell culture model of Parkinson's disease. Toxicology. 245(1-2):101-8.

Sun, F, Kanthasamy A, Song C, Yang Y, Anantharam V, Kanthasamy AG. (2008). Proteasome inhibitor-induced apoptosis is mediated by positive feed-back amplification of PKCdelta proteolytic activation and mitochondrial translocation. J Cell Mol Med. In press.

 V. Anantharam, E. Lehrmann, A. Kanthasamy, Y. Yang, P. Banerjee, KG. Becker, WJ Freed, AG. Kanthasamy (2007). Microarray Analysis of Oxidative Stress Regulated Genes in Mesencephalic Dopaminergic Neuronal Cells: Relevance to Oxidative Damage in Parkinson ’s disease. Neurochem. Intl. 50(6):834-47.

Zhang, A. Kanthasamy, Y. Yang, V.  Anantharam and AG. Kanthasamy. (2007), Neuroprotective effect of PKCdelta inhibitor rottlerin in cell culture and animal models of Parkinson's Disease, J. Pharmacol. Expt. Therapeutics,322:913-922.

Zhang, A. Kanthasamy, Y. Yang, V.  Anantharam and AG. Kanthasamy. (2007). Protein kinase Cd negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons.  J. Neurosci., 27: 5349-5362.

Anantharam V, Kaul S, Song C, Kanthasamy A, Kanthasamy AG. (2007)   Pharmacological inhibition of neuronal NADPH oxidase protects against 1-methyl-4-phenylpyridinium (MPP(+))-induced oxidative stress and apoptosis in mesencephalic dopaminergic neuronal cells. Neurotoxicology. 28:988-97.

Choi, C.J., Anantharam, V., Saetveit, N.J., Houk, R.S., Kanthasamy, A., Kanthasamy AG. (2007), Normal cellular prion protein protects against manganese-induced oxidative stress and apoptotic cell death. Toxicol. Sci., 98: 495-509.

Sun, F., Kanthasamy, V. Anantharamand AG. Kanthasamy. (2007) Environmental neurotoxic chemicals-Induced ubiquitin proteasome dysfunction in the pathogenesis and progression of Parkinson’s Disease. Pharmacol and Ther., 114: 327-344.

Choi, C.J., Kanthasamy, A., Anantharam, V., Kanthasamy, A.G. (2006), Interaction of metals with prion protein: possible role of divalent cations in the pathogenesis of prion diseases.  Neurotoxicol.,  27: 777-87.

Sun, F., Kanthasamy, V. Anantharamand AG. Kanthasamy. (2007) Environmental neurotoxic chemicals-Induced ubiquitin proteasome dysfunction in the pathogenesis and progression of Parkinson’s Disease. Pharmacol and Ther., 114: 327-344.

Choi, C.J., Anantharam, V., Saetveit, N.J., Houk, R.S., Kanthasamy, A., Kanthasamy AG. (2007), Normal cellular prion protein protects against manganese-induced oxidative stress and apoptotic cell death. Toxicol. Sci., 98: 495-509.