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Anumantha G Kanthasamy

Anumantha Kanthasamy
Anumantha Kanthasamy

M.S., M.Phil, PhD.

Chair of the Biomedical Sciences Department and Distinguished Professor / W.E. Lloyd Endowed Chair in Neurotoxicology
Biomedical Sciences
(515) 294-2516
2062 Vet Med
Expertise / Research Area

Parkinson’s disease • Prion and Alzheimer's diseases

Molecular Neurotoxicology • Neuroinflammation

Cell Signaling • Translational research

Dr. Kanthasamy’s research focuses on the cellular and molecular mechanisms of Parkinson’s disease and other protein misfolding neurodegenerative disorders including prion diseases and Chronic Traumatic Encephalopathy, which is similar to Alzheimer's disease.  His NIH-funded research program studies the role of environmental neurotoxic chemicals and other neurotoxic stress on pathogenesis of Parkinson's and other neurodegenerative diseases.  He has also made several fundamental advances in signal transduction mechanisms associated with neuronal cell death processes.  Dr. Kanthasamy has several patents and pursues translational drug discovery for the treatment of neurodegenerative diseases. 

Teaching
• 2005-present   Instructor, BMS 354/554, Pharmacology, Spring Semester, ISU
 
• 2001-2004   Instructor-in-charge, BMS 354/554, Pharmacology,
Spring Semester, ISU
 
• 2006-present   Instructor-in-charge Tox-502, Toxicology Methods,
Interdepartmental Toxicology Program,
Spring semester. ISU.
 
• 2005-present   BMS-575, Cell Biology, ISU.
 
• 2006-2008   GDCB 640, Signal transduction, one lecture, ISU.
 
• 2000-2008   Instructor, BMS 549 Advanced Vertebrate Physiology-I,
Fall Semester, ISU
Education

Postdoctoral training: Medicinal Chemistry & Molecular Pharmacology

            (formerly Pharmacology & Toxicology), 1994,

            Purdue University, West Lafayette, Indiana

Ph.D., Biochemistry, 1989, University of Madras, India.

M.Phil., Biochemistry, 1986, University of Madras, India

M.S., Biochemistry, 1984, University of Madras, India

Selected Publications

Peer Reviewd: 20 selected publications out of over 100.   

PubMed search for Kanthasamy AG

1. Kanthasamy, A.G., Kanthasamy, A., Matsumoto, R.R., Vu, T.Q. and Truong, D.D. (1997), Neuroprotective effect of strychnine-insensitive glycine site antagonist (R)-HA-966 in an experimental model of Parkinson’s disease, Brain Res., 759: 1-8. PMID: 9219856.   

2.   Kanthasamy, A.G., Kitazawa, M., Kanthasamy, A. Anantharam, V., (2003), Role of proteolytic activation of protein kinase C delta (PKCd) in oxidative stress-induced apoptosis, Antioxidants and Redox Signaling, 5: 609-619. PMID: 14580317.

3.   Kitazawa, M., Anantharam, V. and Kanthasamy, A.G. (2003), Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic activation of Protein Kinase Cd in dopaminergic cells: Relevance to oxidative stress and dopaminergic degeneration. Neuroscience, 119: 945-964. PMID: 12831855.

4.   Kaul, S. Kanthasamy, A. Kitazawa, M., Anantharam, V. and Kanthasamy, A.G. (2003), Caspase-3-dependent proteolytic activation of Protein Kinase Cd mediates and regulates MPP+ induced apoptosis in dopaminergic cells: Relevance to oxidative stress and Parkinson’s disease. Eur. J. Neurosci., 18: 1387-1407. PMID: 14511319.

5.  Yang, Y., Anantharam, V. and Kanthasamy, A.G. (2004), Suppression of caspase-3 dependent proteolytic activation of protein kinase Cd by small interfering RNA (siRNA) attenuates MPP+-induced dopaminergic degeneration. Molecular Cellular Neuroscience, 25:406-421.  PMID: 15033169. 

6.     Kaul, S, Anantharam, V, Yang, Y, Choi, C, Kanthasamy, A and Kanthasamy, A G (2005) Tyrosine Phosphorylation Regulates the Proteolytic Activation of PKCd In Dopaminergic Neuronal Cells.  J. Biol. Chem. 280: 28721-30.  PMID: 15961393.

 

7.     Kaul, S,  Anantharam, V, Kanthasamy, A and Kanthasamy, AG (2005) Wild-type a-synuclein interacts with pro-apoptotic proteins PKCd and BAD to protect dopaminergic neuronal cells against MPP+-induced apoptotic cell death.  Molecular Brain Research 139:137-52.  PMID: 15978696.  

8.     Sun, F., Anantharam, V., Zhang, V., Latchoumycandane, C., Kanthasamy, A. and Kanthasamy, A G. (2006) Proteasome inhibitor MG-132 induces dopaminergic degeneration in cell culture and animal models.  Neurotoxicology, 27: 807-815. PMID: 16870259. 

9.   Kanthasamy, AG, Anantharam, V., Zhang, D. Latchoumycandane, C., Jin, H., Kaul, S. and Kanthasamy, A. (2006), A novel peptide inhibitor targeted to caspase-3 cleavage site of a proapoptotic kinase protein kinase C delta (PKCd) protects against dopaminergic neuronal degeneration in Parkinson’s disease models.  Free Radical Biol. Med., 41: 1578-1589. PMID: 16870259.

 

10.  Sun F, Kanthasamy A, Anantharam V, Kanthasamy AG.  (2007). Environmental neurotoxic chemicals-induced ubiquitin proteasome system dysfunction in the pathogenesis and progression of Parkinson's disease.  Pharmacol Ther. 114(3):327-44. PMID: 17521740.  

11.  Zhang, D., Kanthasamy, A. Yang, V.  Anantharam. V. Kanthasamy. AG (2007). Protein kinase Cd negatively regulates tyrosine hydroxylase activity and dopamine synthesis by enhancing protein phosphatase-2A activity in dopaminergic neurons.  J. Neurosci., 27: 5349-5362.  PMID: 17507557. 

12.  Zhang, A. Kanthasamy, Y. Yang, V.  Anantharam and AG. Kanthasamy. (2007), Neuroprotective effect of PKCdelta inhibitor rottlerin in cell culture and animal models of Parkinson's Disease, J. Pharmacol. Expt. Therapeutics, 322:913-922. PMID: 17565007.

 

13.  Carvour M, Song C, Kaul S, Anantharam V, Kanthasamy A, Kanthasamy AG. (2008). Chronic low-dose oxidative stress induces caspase-3-dependent PKCdelta proteolytic activation and apoptosis in a cell culture model of dopaminergic neurodegeneration. Ann N Y Acad Sci. 1139:197-205. PMID: 18991865. 

14.  Sun, F, Kanthasamy A, Song C, Yang Y, Anantharam V, Kanthasamy AG. (2008). Proteasome inhibitor-induced apoptosis is mediated by positive feed-back amplification of PKCdelta proteolytic activation and mitochondrial translocation. J Cell Mol Med. 12, 2467-2481.  PMID: 18298651.

 

15.  Song C, Kanthasamy A, Anantharam V, Sun F, Kanthasamy AG. (2010). Environmental neurotoxic pesticide increases histone acetylation to promote apoptosis in dopaminergic neuronal cells: relevance to epigenetic mechanisms of neurodegeneration.  Mol Pharmacol. 77(4):621-32. PMID: 20097775.  

16.  Ghosh A, Chandran K, Kalivendi SV, Joseph J, Antholine WE, Hillard CJ, Kanthasamy A, Kanthasamy A, Kalyanaraman B. (2010) Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model. Free Radic Biol Med.  49(11):1674-84. PMID: 20828611.

 

17.  Kanthasamy AG, Jin H, Mehrotra S, Mishra R, Kanthasamy A, Rana A. (2009). Novel cell death signaling pathways in neurotoxicity models of dopaminergic degeneration: Relevance to oxidative stress and neuroinflammation in Parkinson's disease. Neurotoxicology.  Dec 11. PMID: 20005250. 

18. Gordon R, Hogan CE, Neal ML, Anantharam V, Kanthasamy AG, Kanthasamy A. (2010) A simple magnetic separation method for high-yield isolation of pure primary microglia. J Neurosci Methods. PMID: 21074565.

19.  Jin H, Kanthasamy A, Anamitra G, Yang Y, Anantharam V, and Kanthasamy AG. (2011) Alpha-synuclein negatively regulates PKCδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 HAT activity. Journal of Neuroscience, 31(6):2035-51.  PMID: 21307242.

20.  Jin H, Kanthasamy A, Anantharam V, Rana A, Kanthasamy AG., (2011) Transcriptional Regulation of Pro-apoptotic Protein Kinase C{delta}: Implications For Oxidative Stress-Induced Neuronal Cell Death. J Biol Chem. 286(22):19840-59. PMID: 21467032.

Leadership

• Chair, Department of Biomedical Sciences, Iowa State University

Associate Chair, Department of Biomedical Sciences, Iowa State University, July 2010-July 2011

Chair, Interdepartmental Toxicology Graduate Program, Iowa State University, 2003 - Present

Director, Iowa Center for Advanced Neurotoxicology (ICAN), 2007 – Present

Vice President-elect, Neurotoxicology Specialty Section, Society of Toxicology, Mar 2011

Chair, Regional Chair Governance Committee, Society of Toxicology, 2009-2010

President, Central States Region, Society of Toxicology, 2009-2010

 

Honors & Awards

• Distinguished Professor and Eugene and Linda Lloyd Chair in Neurotoxicology, ISU, 2008-present

• Chair, NIH study sections –CNNT and CND member conflict panel, 2007  

• Co-Chair, Symposium on ‘Protein Aggregation as the Common Mechanisms of Neurodegeneration' 50th Anniversary Society of Toxicology Annual Meeting, Washington DC, March 2011

• Chair, Graduate Student and Postdoc Awards Committee, Association of Scientists of Indian Origin, Society of Toxicology, Mar 2011

•  Chair, Postdoc Awards Committee, International Neurotoxicology Meeting, Portland, OR, June 2011

•  Chair, International Symposium on Environmental links to Neurodegenerative Disorders, 24th International Neurotoxicology meeting, San Antonio, TX,  Nov 2007

•  Chair, International Symposium on Advances in Neuroscience, Symposium on ‘Molecular Cell Signaling and Transcriptional Regulatory Mechanisms in Neurodegeneration’ Varanasi, India,  2007

•  Co-chair, International Symposium on Health effects of manganese exposure, 23rd International Neurotoxicology Conference, Little Rock, AK. Sept 2006

•  Chair, Symposium on ‘Parkinson’s Disease, Environment and Gene, 21st International Neurotoxicology meeting, Hawaii. July 2003

• Co-Chair, Continuing Education Course ‘Current Trends in Metal Neurotoxicology, Society of Toxicology, 2003

• Chair, 3rd International Conference on Free Radicals in Health and Disease Annual meetings at Vancouver B.C., Canada, 1999-2000

• Chair, 2nd International Conference on Free Radicals in Health and Disease, Annual meetings at Vancouver B.C., Canada, 1998-1999      


Membership Affiliations

1.               Society for Neuroscience

2.               Society of Toxicology

3.               Central States Chapter, Society of Toxicology

4.               International Neurochemistry Society

5.               American Society for Pharmacology and Experimental Therapeutics

6.               American Society for Cell Biology

7.               Society for Free Radical Biology and Medicine

8.               New York Academy of Sciences

9.               American Association for the Advancement of Science

10.           Association of Scientists of Indian Origin, Board of Directors

11.           Gamma Sigma Delta

12.           The American Society for Biochemistry and Molecular Biology