Jesse Hostetter

Dr. Hostetter’s research interest is primarily in host-pathogen interaction, specifically between antigen presenting cells and intracellular pathogens. His research group’s focus is in atypical mycobacterial infections and the model organism is Mycobacterium avium subspecies paratuberculosis (MAP). Ongoing studies include evaluation of the roles of antigen presenting cells and gamma delta T cells in controlling pathogen proliferation, stimulation of adaptive immune responses, and shaping lesion development. Investigations also include evaluation of MAP infection in promoting persistent intestinal inflammation in the mouse. Studies utilize a wide array of techniques including in vivo and in vitro systems, smart polymers, flow cytometry, laser capture microdissection, Q-RT-PCR, SDS PAGE electrophoresis, and immunofluorescence. Multiple collaborations support these projects and include investigators at Iowa State University, University of Iowa, and the National Animal Disease Center. Dr. Hostetter is also the study pathologist on several studies exploring intestinal inflammation in murine models of colitis in collaboration with the Mucosal Immunology Laboratory at the College of Veterinary Medicine.

Ethics in Scientific Research and Writing (VPTH 554), 1 credit, 5-10 students, offered every other summer (session I), instructor in charge with 13.5 hours of lecture each session, semesters taught - summer 02, 04, 06, 08

Systemic Pathology II (VPTH 571), 4 credits, 5 student average, offered every other fall, lecturer on gastrointestinal pathology, 8 hours of lecture each session, semesters taught – fall 02, 05, 07

Mechanisms of Bacterial Pathogenesis (VMPM 625), 4 credits, 10 students average, offered every other spring, lecturer on intracellular pathogens, 4.5 hours of lecture each session, semesters taught – spring 03, 05, 07

Special Pathology (VPTH 422), 4 credits, 120 students, spring semester, lecturer in bovine pathology, 9 hours of lecture, 24 hours of laboratory per session, semesters taught – spring 07, 08

Emerging and Exotic Diseases of Animals, component of VPTH 422 (spring 07, 08) and VPTH 377 (Fall 07, 08), 120 students, online course

Necropsy Laboratory Practicum (VPTH 456), 1 credit, 4 two-week rotations per year, 3-6 senior veterinary students per rotation, semesters taught – spring, fall and summer 01 through 08

Emerging and Exotic Diseases of Animals, (173:172 EXW), 1 credit, elective course in the combined University of Iowa College of Public Health/Iowa State University College of Veterinary Medicine Masters of Public Health Program, offered starting fall 08, 15 hours of lecture each session

Iowa State University, DVM, Veterinary Medicine, 1991

Iowa State University, PhD, Veterinary Pathology, 2000

Diplomate, American College of Veterinary Pathologists (Anatomic Pathology), 2001

N. Cheville, J. Hostetter, B. Thomsen, F. Simutis, Y. Vanloubeeck, E. Steadham.
“Intracellular trafficking of Mycobacterium avium ss. paratuberculosis in macrophages”,
Deutsche Tierarztliche Wochenschrift (German Veterinary Journal), 108, 236-243 (2001)

J. Hostetter, E. Steadham, J. Haynes, T. Bailey, and N. Cheville. “Cytokine effects on maturation of the phagosomes containing Mycobacterium avium subspecies paratuberculosis in J774 cells”, FEMS Immunology and Medical Microbiology. 34 (2): 127-134 (2002)

J. Hostetter, E. Steadham, J. Haynes, T. Bailey, and N. Cheville.
“Phagosomal maturation and intracellular survival of Mycobacterium avium subspecies paratuberculosis in J774 cells”, Comparative Immunology, Microbiology, and Infectious Diseases 26(4):269-283 (2003)

Y. Vanloubbeeck, J. Hostetter, and D. Jones. “Dendritic Cell Biology and their Potential Use in Veterinary Medicine”, Animal Health Research Reviews, 4 (2) 131-142 (2004)

G. Kraus, T. Nguyen, J. Bae, J. Hostetter, E. Steadham. “Synthesis and Antitubercular Activity of Tricyclic Analogs of Puupehenone”, Tetrahedron (2004), 60(19), 4223-4225

J. Hostetter, E. Huffman, K. Byl, E. Steadham. “iNOS immunoreactivity in the granulomatous intestinal lesions of naturally occurring bovine Johne's disease”, Veterinary Pathology, 42(3), 241-249 (2005)

J. Hostetter, R. Kagan, E. Steadham. “Opsonization effects on Mycobacterium avium subspecies paratuberculosis- macrophage interactions”, Clinical and Diagnostic Laboratory Immunology, 12 (6) 793-796 (2005)

A. Jergens, A. Dorn, J. Wilson, K. Dingbaum, A. Henderson, Z. Liu, J. Hostetter, R. Evans, M. Wannemuehler. “Induction of differential immune reactivity to members of the flora of gnotobiotic mice following colonization with Helicobacter bilis or Brachyspira hyodysenteriae”, Microbes and Infection, 8(6), 1602-1610 (2006)

Grubor B, Meyerholz DK, Lazic T, Derscheid RJ, Hostetter JM, Gallup JM, DeMartini JC, Ackermann MR. “Regulation of surfactant protein and defensin mRNA expression in cultured ovine type II pneumocytes by all-trans retinoic acid and VEGF”, International Journal of Experimental Pathology, 87(5), 393-403 (2006)

J. Hostetter, W. Zhang, F. Simutis. “Mycobacterium avium subspecies paratuberculosis infection of cattle does not diminish peripheral blood-derived macrophage mycobactericidal activity”, Immunology Letters, 107(1) 76-79 (2006)

Jergens AE, Wilson-Welder J, Dorn A, Henderson A, Liu Z, Evans R, Hostetter J, Wannemuehler M. “ Helicobacter bilis triggers persistent immune reactivity to antigens derived from the commensal bacteria in gnotobiotic C3H/HeN mice” Gut, 56(7), 934-940, (2007)

F. Simutis, D. Jones and J. Hostetter. “Failure of antigen-stimulated gamma delta T cells and CD4+ T cells from sensitized cattle to upregulate nitric oxide and mycobactericidal activity of autologous Mycobacterium avium subsp. paratuberculosis-infected macrophages”, Veterinary Immunology and Immunopathology, 116 (1-2), (2007)

L. Lei and J. Hostetter. “Limited Phenotypic and Functional Maturation of Bovine Monocyte Derived Dendritic Cells Following Mycobacterium avium subspecies paratuberculosis Infection in Vitro”, Veterinary Immunology and Immunopathology, 120(3-4) 177-186 (2007)

L. Lei, B. L. Plattner, and J. Hostetter “Subcutaneous granulomas induced by Mycobacterium avium subspecies paratuberculosis vs. killed M. paratuberculosis vaccine: distinct morphology, cellular composition, and antigen presenting cell function”, Clinical and Vaccine Immunology, In Press (2008)

K. Gibson-Corley, S. Hostetter, A Ramer-Tait, P Boggiatto, K. Mullen, Hostetter J, C. Petersen. “Disseminated Leishmania infantum Infection in Two Sibling Foxhound Dogs Due to Possible Vertical Transmission” The Canadian Veterinary Journal, In press 2008

J.R. Stabel , M.V. Palmer B. Harris, B. Plattner, J. Hostetter, S. Robbe-Austerman a
“Pathogenesis of Mycobacterium avium subsp. paratuberculosis in neonatal
calves after oral or intraperitoneal experimental infection” Veterinary Microbiology. 2009 In Press

Z. Liu, J Wilson-Welder, J Hostetter, A Jergens and M Wannemuehler, “Oral treatment with hypoxoside ameliorates Brachyspira hyodysenteriae-induced murine colitis” Microbes and Infection, 2009 In Press

C. Johnson, E. May, R. Myers, and J. Hostetter, “Neutrophilic dermatitis resembling Sweet's syndrome in a 7-year-old Standard Poodle”, Veterinary Dermatology 2009, In Press

B. Platter and J. Hostetter, Cutaneous viral papilloma with local extension and subungual cyst formation in a dog, J. Vet. Diagn. Invest. Vol. 21 July 2009

Zhong Y, Liu Z, Henderson A, Lee K, Hostetter J, Wannemuehler M, Hendrich S. Increased CYP4B1 mRNA Is Associated with the Inhibition of Dextran Sulfate Sodium-Induced Colitis by Caffeic Acid in Mice. Exp Biol Med, In Press 2009

Phi Kappa Phi National Honor Society

Phi Zeta National Veterinary Honor Society

NCT - 188 Committee on Paratuberculosis formed collaborative research group entitled: "Paratuberculosis, Tuberculosis, and Other Mycobacteriosis of Domestic and Wild Animals", Chicago, Illinois, 2002

Chair, Ultrastructural Pathology Session, American College of Veterinary Pathologists Annual Meeting, Banff Canada, 2004

Member, Organizing Committee for 10th Annual International Colloquium for Paratuberculosis 2008

Member, American Veterinary Medical Association, 1991-present

Diplomate, American College of Veterinary Pathologists, 2001-present

Member, C.L. Davis Foundation

Member, American Society for Microbiology, 2001-present

Member, American Society for Investigative Pathology, 2003-present

Member, International Association for Paratuberculosis, 2002-present

Member, Johne's disease Interdisciplinary Program (JDIP), 2004-present

Member, International Society for Infectious Disease, 2008-present