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Richard Martin

Richard Martin
Richard Martin

B.V.Sc., Ph.D., D.Sc., Dip. E.C.V.P.T., M.R.C.V.S.

Professor and Director of Graduate Education
Biomedical Sciences
(515) 294-2470
2018 Vet Med
Expertise / Research Area

We are interested in molecular and cellular pharmacology with a focus on drugs that act on ion-channels of nematodes, including those parasites that cause disease in humans in the developing world and in animals.  

Our work is supported by NIH and NSF and involves molecular, cellular, pharmacological, electrophysiological, Xenopus expression and microfluidic techniques to study the effects of drugs like emodepside, pyrantel, derquantel and ivermectin on a range of membrane ion-channels. We study a range of nematodes including, C. elegans, Brugia malayi, Ascaris suum, Oesophagostomum dentatum and Haemonchus contortus.  We encourage potential graduate students and post-doctoral researchers to contact us if they are interested in our research.

Teaching

It is very important to understand the mode of action of drugs (pharmacology).  My teaching focuses on those drugs that acts on ion-channels and includes the action of cardiac drugs, drugs that act on nematode parasites, with classes for neuroscience and toxicology graduate students and DVM students. 

 

  • Tox 501: Pharmacokinetics Graduate Toxicology
  • Tox 502: Instructor in charge Graduate Toxicology Laboratory Techniques
  • BMS 443: DVM, Veterinary Clinical Pharmacology
  • BMS 354: DVM, Veterinary General Pharmacology
  • Neuro 556: Ion-channels, Chemical Transmitters and Neuropharmacology
  • BMS 575 Graduate Cell Biology 
Education
 
  • 1968-72           B.V.Sc. University of Liverpool
  • 1972-              M.R.C.V.S. Member of the Royal College  of Veterinary Surgeons                                   
  • 1972-73          Diploma in Neurophysiology, University of Edinburgh 
  • 1973-77          Ph.D., University of Liverpool
  • 1997                               D.Sc.: Doctor of Science, University of Edinburgh 
  • 1998               Dip. ECVPT:  Diplomate European College of Vet Pharmacology & Toxicology
Selected Publications

 

 Recent Publications 

  • Peng L, Depeng M., Martin R.J. and Dong, L.  (2012). An integrated fiber-optic microfluidic device for multicellular organismal biomechanics.  Lab on a Chip,12, 3458-3466
  • Charvet, C.L., Robertson, A.P., Cabaret, J., Neveu, C. and Martin, R.J. (2012).   Selective effect of the anthelmintic bephenium on Haemonchus contortus levamisole-sensitive. Invertebrate Neuroscience.  Invertebrate Neuroscience (2012) 12, 43–51 DOI 10.1007/s10158-012-0130-0
  • Martin, R.J. Robertson, A.P. Buxton, S.K. Beech R. Charvet,C.L. and Neveu, C. and (2012). Levamisole Receptors: a second awakening.  Trends in Parasitology, 28 289-296.   
  • R. J. Martin, S.K. Buxton, C. Neveu, C. L. Charvet, and A. P. (2011) Emodepside and SL0-1 Potassium Channels: A Review.  Experimental Parasitology.  doi:10.1016/j.exppara.2011.08.012 
  • Chen, B., Deutmeyer, A., Carr, R, Robertson, A.P. Martin, R.J., and Pandey S. (2011) Microfluidic bioassay to characterize parasitic nematode phenotype and anthelmintic resistance. Parasitology, 138, 80-88
  • S.K. Buxton, C. Neveu, C. L. Charvet, A. P. Robertson, and R. J. Martin (2011). On the Mode of Action of Emodepside: Slo(w) Effects on Membrane Potential and Voltage-Activated Currents in Ascaris suum. British Journal of Pharmacology.  164: 453–470
  •  Carr, J.A., Parashan, A., Gibson, R., Robertson, A.P., Martin, R.J., Pandey, S. (2011). A microfluidic platform for high-sensitivity, real-time drug screening on C. elegans and parasitic nematodes. Lab on a Chip. 11, 2385-2396.
  •  Beech R.N., Skuce, P., Bartley, D.J. Martin, R.J., Pritchard, R.K. and Gilliard, J.S. (2011) Anthelmintic resistance: markers for resistance or susceptibility?  Parasitology, 138, 2, 160-174.
  • Robertson, A.P., Puttachary, S. and Martin, R.J. (2011). Single-channel recording from adults Brugia malayi. Invertebrate Neuroscience, 11, 53-57. 
Leadership
  • 1999 - 2007   Professor and Chair, Department of Biomedical  Sciences                                          
  • 2005-2009     NIH, PTHE study section
  • 2008-2011     Co Chair Neuroscience program
  • 2011-            Chair &  DOGE Interdepartmental Toxicology program
  • 2012-            Chair & DOGE BMS Graduate Program
  • 2012-            Editorial Board Veterinary Record
  • 2012-            Chair Education and Residency Committee European College             Veterinary Pharmacology and Toxicology
Honors & Awards

·         1997:   D.Sc., University of Edinburgh

·         1998: Personal Chair, Edinburgh University,

·    2002 –2003:  NIH, NIAID Study Section Member:  TMP, Tropical Medicine Parasitology Federal Research review body

·         2004-8: NIH, NIAID Study Section Member: PTHE,  Pathogenic Eukaryotes, Federal Research review body

·      2007 American Society of Parasitology Bueding and von Brand Lectureship (For Outstanding Scientific contributions to parasite biochemistry and pharmacology).

·      2008 NIH, NIAID Study Section ad hoc DDR, Drug Development and Resistance, Federal Research review body

·         2009 Ad hoc Challenge Grants RFA-OD-09-003 NIH/NIAID

            2009-    Member NIH College of CSR  Reviewers

·         2010 K22 Ad hoc K22 NIH/NIAID

·         2012 SBIR Grant ZRG1 NIH/NIAID

·         Ad hoc Study section NIH NIAID’s Microbiology and Infectious Diseases B Subcommittee (MID-B).

·         Ad hoc Study section NIH Special Emphasis Panel, Pathogenic Eukaryotes (PTHE)

 

Memberships

 

 

1.      Member of the Physiological Society.

2.      Member of the British Pharmacological Society.

3.      Member of the Royal College of Veterinary Surgeons (MRCVS)

4.      Member of the British Society of Parasitology

5.      Diplomate of the European College for Veterinary Pharmacology and Therapeutics (ECVPT)

6.      American Association of Veterinary Parasitology

7.      American Society of Veterinary Parasitology

8.      Society for Toxicology