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Recent Publications and Abstracts

Publications 

Gupta, P. and Miller, C. L.  2014. HIF-1a downregulation and apoptosis in hypoxic prostate tumor cells infected with oncolytic Mammalian orthoreovirus. Oncotarget, 5(1.2), 561-574.

Buehler, J., Lager, K., Vincent, A., Miller, C., Thacker, E., and Jahnke, B. 2014. Issues encountered in development of an ELISA for use in detecting H5N1 exposure in swine. Journal of Veterinary Diagnostic Investigation, 26(2), In press.

Carroll, K., Hastings, C., and Miller, C.L., 2014. Amino-acids 78 and 79 of mammalian orthoreovirus protein  µNS are necessary for stress granule localization, core protein λ2 interaction, and de novo virus replication. Virology, 448: 133-145.

Kappes, M., Miller, C. L., and Faaberg, K. 2013. Highly Divergent Strains of Porcine Reproductive And Respiratory Syndrome Virus Incorporate Multiple Isoforms of Nonstructural Protein 2 into Virions. Journal of Virology 87:24 13456-13465.

Buehler,J. Navi, D., Lorusso, A., Vincent, A., Lager, K., and Miller, C.L. 2013.  Influenza A virus PB1-F2 protein expression is regulated in a strain-specific manner by sequences located downstream of the PB1-F2 initiation codon J. Virol. 87(19):10687-99.

Chen, Q., Madson,D.,  Miller, C. L.,  and  Harris, H. 2012. Vaccine development for protecting swine against influenza virus. Animal Health Research Reviews, 13(2); 181–195.

Hines, N., Killian, M., Pedersen, J., Reising, M. Mosos, N., Mathieu-Benson, C., and Miller, C. L.  2012. An rRT-PCR Assay to Detect the Matrix Gene of a Broad Range of Avian Paramyxovirus Serotype-1. Avian Diseases56(2):387-395.2012 

Hines, N., and Miller, C. L. 2012. Avian Paramyxovirus Serotype-1: A Review of Disease Distribution, Clinical Symptoms and Laboratory Diagnostics. Veterinary Medicine International, Volume 2012, Article ID 708216, 17 pages, doi:10.1155/2012/708216.

Miller, C. L. 2011. Stress Granules and Virus Replication. Future Virology, Nov 2011, Vol. 6, No. 11, Pages 1329-1338.

Qin, Q., Hastings, C., Carroll, K., and Miller, C. L. 2011. Mammalian Orthoreovirus escape  from host translational shutoff correlates with stress granule disruption and is independent of eIF2α phosphorylation and PKR.  Journal of Virology 85 (17): 8798-8810.

Firth, A. E.,  B. J. Blitvich, N. M. Wills, C. L. Miller, J. F. Atkins. 2010.  Evidence for ribosomal frameshifting and a novel overlapping gene in the genomes of insect specific flaviviruses. Virology 30;399(1):153-66.

Li, G, Y. Feng,, S.  Kariyawasam, K. A. Tivendale, Y. Wannemuehler, F. Zhou, C. L. Miller, C. M. Logue, and L. K. Nolan. 2010.  AatA is a novel autotransporter and virulence factor of avian pathogenic Escherichia coli. Infection and Immunity, 78.3: 898-906.

Miller, C. L., Arnold, M., Broering, T., Hastings, C., and Nibert, M.  2010.  Localization of mammalian orthoreovirus proteins to cytoplasmic factory-like structures via nonoverlapping regions of μNS.  Journal of Virology,  84 (2): 867-882. Co-corresponding author.

Qin, Q., Hastings, C., and Miller, C.  2009.  Mammalian orthoreovirus particles induce and are recruited to cellular stress granules. Journal of Virology, 83(21):11090-101.

Miller, C. L., M. M. Arnold, T. J. Broering, J. Kim, J. B. Dinoso, and M. L. Nibert. 2007.  A virus-derived platform for easily visualizing protein-protein associations in cells. Mol. Cell. Proteomics 6: 1027 – 1038.  Co-corresponding author.  Cover illustration.

Abstracts

Carroll, K., and Miller, C. L. 2013. Investigation of mammalian orthoreovirus escape from host translational shutoff. The 32nd American Society for Virology Meeting, July 20-24, University Park, PA. Oral presentation.

Gupta, P., and Miller, C. L. 2013. Mammalian Orthoreovirus infection of hypoxic prostate tumor cells induces downregulation of HIF-1a and apoptotic tumor cell death. 7th Int'l Meeting on Replicating Oncolytic Virus Therapeutics. June 15-18, Quebec City, Quebec, Canada. Oral and poster presentations.

Gupta, P., Darling, R., and Miller, C. 2012. Mammalian orthoreovirus induces apoptosis in hypoxic prostate tumor cells and downregulates HIF-1a via RACK1-mediated proteasome degradation and translational inhibition. The  31st American Society for Virology Meeting, July 21-25, Madison, WI. Oral presentation. 

Carroll, K. and Miller, C. 2012. Investigation of the role of mammalian orthoreovirus muNS protein in stress granule modulation. The 31st American Society for Virology Meeting, July 21-25, Madison, WI. Oral presentation.

Buehler, J., Navi, D., Vincent, A., Lorusso, A., Lager, K., and Miller, C. 2012. Elucidating the role of  virus lineage and RNA sequence in translational regulation of influenza virus PB1-F2. The  31st American Society for Virology Meeting, July 21-25, Madison, WI. Poster presentation.

Gupta, P., and Miller, C. L. 2012. Mammalian Orthoreovirus downregulates HIF-1a in hypoxic prostate tumor cells via RACK1-mediated proteasomal degradation and translational inhibition. 2012 American Association for Cancer Research Annual Meeting. Mar 31-Apr 4, Chicago, IL. Poster Presentation. Selected as a Late Breaking Abstract.  

Gupta, P. and Miller, C. 2011. Investigation of the impact of mammalian orthoreovirus infection on hypoxic cancer cells. American Society for Virology 30th Annual Meeting, University of Minnesota, Minneapolis, MN, July 16-20. Oral Presentation

Buehler, J., McCullough, D., Kohns, C., Loving, C., Lorusso, A. Vincent, A., Lager, K., and Miller, C. 2011. Characterization of swine influenza virus PB1-F2 properties in swine and human cells. American Society for Virology 30th Annual Meeting, University of Minnesota, Minneapolis, MN, July 16-20. Oral Presentation. 

Qin, Q., Hastings, C., and Miller, C.  2010.  Disruption of Stress Granules is Important for Mammalian Orthoreovirus Escape from Host Translational Shutoff.  RNA in Motion   Symposium, Sept. 9-12, Ames, IA.  Poster presentation. 

Miller, A. G., Gupta, P., and Miller, C.  2010.  Investigation of the impact of mammalian orthoreovirus infection on hypoxic tumor cells.  10th Annual Merial-NIH National Veterinary Scholars Symposium.  Athens, GA, August 5-8.  Poster Presentation.  Poster Award, 1 of 6 from 87 posters.

Cutler TD, Hoff SJ, Wang C, Warren KJ, Zhou F, Qin Q, Miller C, Ridpath JF, Yoon K-J, Zimmerman J.  September 2010.  Inactivación de agents patógenos virales seleccionados mediante luz ultravioleta (UV254).  XXII Congreso Panamericano de Ciencias Veterinarias.  Lima, Peru. 

Qin Q., Gupta, P, Hastings, C., and Miller, C. L. 2010.  Mammalian orthoreovirus translation  is refractory to phosphorylation of eIF2α caused by oxidative stress or hypoxia. American Society for Virology 29th Annual Meeting, Montana State University, Bozeman, MT, July 17-21. Oral Presentation.

Buehler, J., McCullough, D., Loving, C., Vincent, A., Lager, K., and Miller, C.  2010. Investigation of the function of the influenza A virus PB1-F2 protein during infection of swine and human cells with a predominant circulating strain. American Society for Virology 29th Annual Meeting, Montana State University, Bozeman, MT, July 17-21. Poster Presentation.

Qin, Q., Hastings, C., and Miller, C.  2010.  Disruption of Stress Granules is Important for Mammalian Orthoreovirus Escape from Host Translational Shutoff.  Keystone Symposium on Cell Biology of Virus Entry, Replication, and Pathogenesis.  Feb. 17-21, Taos, NM. Poster presentation.

Cutler T, Hoff S, Wang C, Warren K, Zhou F, Qin Q, Miller C, Ridpath J, Yoon K-J, Zimmerman J.  October 2009.  UV254 Inactivation of Selected Viral Pathogens.  52st Annual Conference, American Association of Veterinary Laboratory Diagnosticians.  San Diego, California, p. 124. Oral presentation.

Cutler TD, Hoff SJ, Wang C, Warren KJ, Zhou F, Qin Q, Miller C, Ridpath JF, Yoon K-J, Zimmerman J.  December 2009.  UV254 inactivation of selected viral pathogens.   Proc 2009 International PRRS Symposium.  Chicago, Illinois, p 66. Poster presentation.

Buehler, J., Thacker, E., Lager, K., Miller, C., and  Janke, B.  Serologic detection of H5 Influenza virus infection in swine using ELISA techniques.  The 5th International Veterinary Vaccines and Diagnostics Conference.  July 19-23, Madison WI.  Oral and Poster Presentation.

Qin, Q., Hastings, C.,  and Miller, C. L..  Mammalian orthoreovirus infection interferes with stress granule formation.  American Society of Virology 27th Annual Meeting, July12-16, 2008, Ithaca, New York.  Poster presentation.