Biological and Physical Properties
Allan et al. (1994) demonstrated that PCV1 was stable at pH 3, was stable at 56˚C and at 70˚C for 15 minutes, and was resistant to inactivation after exposure to chloroform. The buoyant density of PCV1 in CsCl has been reported to be 1.37 g per cm3 by Tischer et al. (1974), and it has been reported to be 1.36-1.37 g per ml CsClby Allan et al. (1994). The sedimentation coefficient (S) was determined to be 57S when compared with the sedimentation coefficient of a bovine enterovirus (Allan et al., 1994).
PCV2 is readily isolated from tissue samples that have been stored at -70˚C (Ellis et al., 1998). PCV2 was shown to be resistant to some disinfectants (Nolvasan®, DC&R®, Weladol®, or ethanol) but virus titers were significantly reduced by sodium hydroxide , Virkon® S, and others (Royer et al., 2001).
Allan GM, Phenix KV, Todd D, McNulty MS: Some biological and physico-chemical properties of porcine circovirus. Zentralbl Veterinarmed B. 41:17-26, 1994
Ellis J, Hassard L, Clark E, Harding J, Allan G, Willson P, Strokappe J, Martin K, McNeilly F, Meehan B, Todd D, Haines D: Isolation of circovirus from lesions of pigs with postweaning multisystemic wasting syndrome. Can Vet J. 39:44-51, 1998
Tischer I, Rasch R, Tochtermann G: Characterization of papovavirus- and picornavirus-like particles in permanent pig kidney cell lines. Zbl Bakt Hyg I Abt Orig A. 226:153-167, 1974
Royer RL, Nawagigul P, Halbur PG, Paul PS: Susceptibility of porcine circovirus type 2 to commercial and laboratory disinfectants. J Swine Health Prod. 9:281-284, 2001