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Growth in Cell Culture

Allan et al. (1994) found PCV1 growth confined to porcine-derived cell cultures and Vero cultures. Primary bovine and ovine cell cultures were also found to be susceptible; however, passage of cell lysates resulted in reduction or elimination of cytoplasmic staining. There was no indication of growth in avian-derived cell cultures (Allan et al., 1994). Hattermann et al. (2004) infected 9 different human cell lines with PCV1 and PCV2 to investigate whether PCV2 can infect and replicate in human epithelial cells and lymphocytes. The results indicated that although PCV gene expression and replication took place in human cells, the infection was non-productive, since the infection was not passed when virus-free cells were inoculated with supernatant of PCV-infected human cells. The authors suggested protein targeting to be disturbed in human cells (Hattermann et al. 2004).

References:

Allan GM, Phenix KV, Todd D, McNulty MS: Some biological and physico-chemical properties of porcine circovirus. Zentralbl Veterinarmed B. 41:17-26, 1994

Hattermann K, Roedner C, Schmitt C, Finsterbusch T, Steinfeldt T, Mankertz A: Infection studies on human cell lines with porcine circovirus type 1 and porcine circovirus type 2. Xenotransplantation. 11:284-294, 2004

HOST RANGE

Pigs

Ruminants

Mice

Rabbits

Humans

Poultry, Horses, Guinea Pigs, Cats and Dogs

PCV2

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