Tischer et al. (1995) found weak reactivity to PCV1 antigen in serum samples from healthy humans (116 tested, 20.07% positive), blood donors (175 tested, 8.6% positive), and hospitalized adult patients with fevers (188 tested, 23.9% positive) by IFA. In contrast, sera of 200 humans were found to be negative for PCV1-specific antibodies by IFA (Allan et al. 1994) and 120 randomly selected samples from healthy humans in Northern Ireland were found to be negative by IFA and ELISA for PCV2-specific antibodies (Allan et al., 2000). Ellis et al. (2000) tested serum from 54 swine veterinarians and 6 academic veterinarians and laboratory workers (involved in PCV2 research for several years) with a competitive PCV2 ELISA, a whole cell PCV2 ELISA, and a whole cell PCV1 ELISA. All samples were found to be negative for PCV2 and PCV1 specific antibodies (Ellis et al., 2000).
Allan GM, McNeilly F, McNair I, Curran MD, Walker I, Ellis J, Konoby C, Kennedy S, Meehan B: Absence of evidence for porcine circovirus type 2 in cattle and humans, and lack of seroconversion or lesions in experimentally infected sheep. Arch Virol. 145:853-857, 2000
Allan GM, Phenix KV, Todd D, McNulty MS: Some biological and physico-chemical properties of porcine circovirus. Zentralbl Veterinarmed B. 41:17-26, 1994
Ellis JA, Wiseman BM, Allan G, Konoby C, Krakowka S, Meehan BM, McNeilly F: Analysis of seroconversion to porcine circovirus 2 among veterinarians from the United States and Canada. J Am Vet Med Assoc. 217:1645-1646, 2000
Tischer I, Bode L, Apodaca J, Timm H, Peters D, Rasch R, Pociuli S, Gerike E: Presence of antibodies reacting with porcine circovirus in sera of humans, mice, and cattle. Arch Virol. 140:1427-1439, 1995