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Recent Publications

 Publications for the last three years:

*Lin, J., M. Akiba, O. Sahin, and Q. Zhang. 2005. CmeR functions as a transcriptional repressor for the multidrug efflux pump CmeABC in Campylobacter jejuni. Antimicrob. Agents Chemother.  49:1067-1075.

*Luo N, S. Pereira, O. Sahin, J. Lin, S. Huang, L. Michel, and Q. Zhang. 2005. Enhanced in vivo fitness of fluoroquinolone-resistant Campylobacter jejuni in the absence of antibiotic selection pressure. Proc. Natl. Acad. Sci. U. S. A. 102:541-546.

Raphael, B. H., S. Pereira*, E. Dave, G. A. Flom, Q. Zhang, J. M. Ketley, and M. E. Konkel. 2005. The Campylobacter jejuni response regulator, CBbrR, modulates sodium deoxycholate resistance and chicken colonization. J. Bact. 187(11):3662-70.

*Lin, J.,  C.  Cagliero, B. Guo, Y-W., Barton,  M. C. Maurel, S. Payot, and Q. Zhang. 2005. Bile salts modulate the expression of multidrug efflux pump CmeABC in Campylobacter jejuni. J. Bacteriol. 187:7417-7424.

*Akiba, M., J. Lin, Y-W, Barton, and Q. Zhang. 2006. Interaction of CmeABC and CmeDEF in conferring antimicrobial resistance and maintaining cell viability in Campylobacter jejuni. J. Antimicrobial Chemother. 57: 52-60.

*Luangtongkum, T., T. Y. Morishita, A. J. Ison, S. Huang, P. F. McDermott, and Q. Zhang. 2006. Effect of conventional and organic production practices on the prevalence and antimicrobial resistance of Campylobacter spp. in poultry. Appl. Environ. Microbiol. 72:3600-3607.

Payot, S., J-M Bolla, D. Corcoran, S. Fanning, F. Mégraud , and Q. Zhang . 2006. Mechanisms of fluoroquinolone and macrolide resistance in Campylobacter spp. Microbes Infect. 8:1967-1971.

Zhang, Q., O. Sahin, P. F. McDermott, and S. Payot. 2006. Fitness of antimicrobial resistant Campylobacter and Salmonella. Microbes Infect. 8:1972-1978.

*Yan, M., O, Sahin, J. Lin, and Q. Zhang. 2006. Role of the CmeABC efflux pump in the emergence of fluoroquinolone-resistant Campylobacter under selection pressure. J. Antimicrobial. Chemother. 58:1154-1159.

*Luangtongkum, T., T. Y. Morishita, A. B. Al-Tayeb, A. J. Ison, and Q. Zhang 2007. Comparison of antimicrobial susceptibility testing of Campylobacter spp. by the agar dilution and the agar disk diffusion methods. J. Clin. Microbiol. 45:590-594.

Su, C. C., *F. Shi, R. Gu, M. Li, G. McDermott, E. W. Yu, and Q. Zhang. 2007. Preliminary structural studies of the transcriptional regulator CmeR from Campylobacter jejuni. Acta Crystallograph. Sect. F. Struct. Biol. Cryst. Commun. 63:34-36.

*Huang S., O. Sahin, and Q. Zhang. 2007. Infection induced antibodies against the major outer membrane protein of Campylobacter jejuni mainly recognize conformational epitopes. FEMS Microbiol. Lett. 272: 137-143.

 *Lin, J., M. Yan, O. Sahin, S. Pereira, Y.-J. Chang, and Q. Zhang. 2007. Effect of macrolide usage on the emergence of erythromycin-resistant Campylobacter in chickens. Antimicrob. Agents  Chemother. 51: 1678-1686.

Gu, R, C-C Su, *F. Shi, M. Li, G. McDermott, Q. Zhang and E. W. Yu. 2007. Crystal Structure of the transcriptional regulator CmeR from Campylobacter jejuni.  J. Mol. Biol. 372:583-593.

*Jeon B. and Q. Zhang. 2007. Cj0011c, a periplasmic single- and double-stranded DNA binding protein, contributes to natural transformation in Campylobacter jejuni. J. Bact. 189:7399-7407.

Song, Li, Y-B., Ning, Q. Zhang, C. Yang, G. Gao, and J.-F. Han. 2007. In vitro transfer of antimicrobial resistance determinants and in vivo fitness of antibiotic resistant Escherichia coli. Scientia Agricultura Sinica. 40: 2621-2625.

*Guo, B., Y. Wang, F. Shi, Y.-W. Barton, P. Plummer, D. L. Reynolds, D. Nettleton, T. Grinnage-Pulley, J. Lin and Q. Zhang. 2008. CmeR functions as a pleiotropic regulator and is required for optimal colonization of Campylobacter jejuni in vivo. J. Bact. 190:1879-1890.

*Sahin, O., P. J. Plummer, D. M. Jordan, K. Sulaj, S. Pereira, S. Robbe-Austerman, L. Wang, M. J. Yaeger, L. J. Hoffman, and Q. Zhang. 2008. Emergence of a tetracycline-resistant Campylobacter jejuni clone associated with ovine abortion in the United States. J. Clin. Microbiol. 46:1663-1671.

*Jeon B., W. Muraoka, Q. Zhang. 2008. Role of Cj1211 in natural transformation and emergence of antibiotic resistance in Campylobacter jejuni. Antimicrob. Agents Chemother. 52:2699-2708.

*Han, J., O. Sahin, Y.-W. Barton, and Q. Zhang. 2008. Key role of Mfd in the development of fluoroquinolone resistance in Campylobacter. PLoS Pathog 4(6): e1000083. doi:10.1371/journal.ppat.1000083.

Yun, J., B. Jeon, Y.-W. Barton, P. Plummer, Q. Zhang, and S. Ryu. 2008. Role of the DksA-like protein in the pathogenesis and diverse metabolic activity of Campylobacter jejuni. J. Bacteriol. 190:4512-4520.

Luangtongkum, T., T. Morishita, L. Martin, I. Choi, O. Sahin and Q. Zhang. 2008. Prevalence of tetracycline-resistant Campylobacter in organic broilers during a production cycle. Avian Diseases 52: 487-490.

*Jeon B, W. Muraoka, A. Scupham, and Q. Zhang. 2009. Roles of lipooligosaccharide and capsular polysaccharide in antimicrobial resistance and natural transformation of Campylobacter jejuni. J. Antimicrob. Chemother. 63:462-468

*Jeon B. and Q. Zhang. 2009. Sensitization of Campylobacter jejuni to fluoroquinolone and macrolide antibiotics by antisense inhibition of the CmeABC multidrug efflux transporter. J. Antimicrob. Chemother. 63:946-948.

*Luangtongkum, T., B. Jeon, J. Han, P. Plummer, C. M. Logue, and Q. Zhang. 2009. Antibiotic resistance in Campylobacter: molecular mechanisms and ecology of emergence, transmission and persistence. Future Microbiol. 2:189-200.

Routh M.D., C.C. Su, Q. Zhang, and E.W, Yu. 2009. Structures of AcrR and CmeR: Insight into the mechanisms of transcriptional repression and multi-drug recognition in the TetR family of regulators. Biochim. Biophys. Acta. In press.

*Jeon, B., W. T. Muraoka1, and Q. Zhang. 2009. Advances in Campylobacter biology and implications for biotechnological applications. Microbial Biotechnology. In press.

Rajashekara, G., M. Drozd, D. Gangaiah, B. Jeon, Z. Liu, and Q. Zhang. 2009. Functional characterization of the twin-arginine translocation System in Campylobacter jejuni. Foodborne Pathogens and Disease. In press.

Burrough, Eric R., O. Sahin, Paul J. Plummer, Q. Zhang, and M. J. Yaeger. 2009. Pathogenicity of an emergent, ovine abortifacient Campylobacter jejuni clone following oral inoculation in a pregnant guinea pig model. AJVR. In press