Dr. Thoen conducts investigations on the pathogenesis of Mycobacterium bovis, M. tuberculosis, M. avium ss paratuberculosis, M. avium ss avium and M. avium ss intracellulare in domestic and captive wild animals. The focus of research is to provide an improved understanding of host immune responses that can be used in developing more reliable in vivo and in vitro diagnostic tests.

Infectious Diseases of Captive Wild Animals -- VMPM 409 - Instructor
Zoo Medicine Preceptorship -- VMPM 494 - Instructor in Charge
Zoonosis -- VMPM 536 (Graduate Course) - Instructor in Charge
Wild Animal Health and Conservation -- VMPM 496 -- Instructor in Charge
Pathogenic Bacteriology - VMPM 586 - Lecturer
 

D.V.M.: University of Minnesota, 1961.
Ph.D.: University of Minnesota, Mayo Graduate School of Medicine, 1971.
Honorary Diplomate: American Veterinary Epidemiology Society, 2005

Selected from more than 200 publications.

Thoen, C. O., LoBue, P. and de Kantor, I. 2010.  (Invited).  Why has Zoonotic Tuberculosis not received much attention?  International Journal Tuberculosis and Lung Disease 14(9):1073-1074

de Kantor, I. N., LoBue, P. A. and Thoen C. O. 2010. Human Taberculosis Caused by Mycobacterium bovis in the United States, Latin America, and the Caribean. International Journal on Taberculosis and Lung Disease 14(11):1369-1373

Kaneene, J. B., Miller R. A., deKantor I. N. and Thoen C. O. 2010. Tuberculosis in Wild Animals. International Journal on Taberculosis and Lung Disease 14(12): In Press

Thoen, C.O. 2010.  Tuberculosis and other microbacterial diseases In: Merck Veterinary Manual, Tenth Edition. Ed. Cynthia Kahn & S. Line, Merck and Co. Inc. Whitehouse Station N.J.

Qual, D. A., Kaneene, J. B., Varty, T. J., Miller, R. and Thoen, C. O. 2010. Lack of association between the occurrence of Crohn's disease and occupational exposure to dairy and beef cattle herds infected with Mycobacterium avium subspecies paratuberculosis. Journal Dairy Science 93:2371-2376.

Platt, R., Thoen, C. O., Stahberger, R. J., Chiang, Y. W., Roth, J. A. 2010. Evaluation of the cell-mediated immune response to reduced doses of Mycobacterium avium ssp. paratuberculosis vaccine in cattle.  Veternary Immunology and Immunopathology 136 (1-2): 122-126.

LoBue, P., Enarson, D. A., and Thoen, C. O. 2010, Tuberculosis in humans and animals: An Overview. International Journal Tuberculosis and Lung Disease 14(9):1075-1078

Thoen, C. O., LoBue, P. A., Enarson, D. L., Kaneene, J. and de Kantor, I. 2009.  (Invited). Tuberculosis: a reemerging disease in animals and humans.  Vet. Italiania 45(1): 135-181

Olsen S. C., Bellaire, B.H., Roop, R.M.II and Thoen, C. O. 2010. Brucella, In: Pathogenesis of Bacterial Infections in Animals. pp. 429-442 Fourth Edition, Ed. by C.L. Gyles, J.F. Prescott, J.G. Songer and C. O. Thoen Wiley/Blackwell Ames, IA

Thoen, C.O., Williams, D. E. and Thoen, T. C. . 2008 (Invited). Discovery of Streptomycin for the Treatment of Tuberculosis. One Health Newsletter. 1(3): 5-6

Olsen, I. Barletta, R. & Thoen, C. O., 2010.  Mycobacterium. In: Pathogenesis of Bacterial Infections in Animals. In: Pathogenesis of Bacterial Infections in Animals. Fourth Edition, pp. 113-132 Ed. by C.L. Gyles, J.F. Prescott, J.G. Songer and C.O. Thoen, Wiley/Blackwell Publisher

Wilkins, M.J. Bartlett, P. C., Berry, D. E., Perry, R. L. Fitzgerald, S. D., Bernardo, T. M., Thoen, C. O. and Kaneene, J. B. 2008. Absence of Mycobacterium bovis infection in dogs and cats residing on infected cattle farms: Michigan, 2002. Epidemiol. Infect. 1:1-7.

Thoen, C. O. and LoBue, P. A. 2007 (Invited). Mycobacterium bovis tuberculosis: Forgotten, but Not Gone. Lancet 369(9569):1236-1238

Thoen, C. O., 2007. Johne's Disease. In: McGraw-Hill Encyclopedia of Science and Technology ed. L. Geller. Tenth Edition. McGraw-Hill Professional New York 9:515-516

Thoen, C.O. and Barletta, R. 2006. Pathogenesis of Mycobacterium bovis. In. Mycobacterium bovis Infection in Animals and Humans. Eds. C. O.Thoen, J. H. Steele and M. J. Gilsdorf. Chapter 4. pp 18-33. Blackwell Publishing, Ames, IA

Platt, R., Roth, J. A., Royer, R. L. and Thoen, C. O. 2006. Monitoring responses by use of five-color flow cytometry in subsets of peripheral T cells obtained from cattle inoculated with a killed Mycobacterium avium
subsp paratuberculosis vaccine. Amer. Jour. Vet. Res. 67(12): 2050 - 2058

Thoen, C.O., LoBue, P. A. and de Kantor, I. 2006. The importance of Mycobacterium bovis as a Zoonosis. Vet. Microbiol. 112: 339 – 345.

Thoen, C. O., Robbe-Austerman, S., Whitlock, R. H., Hoards Rubl. 2006. Don't overlook vaccination for control of Johne's. p. 666, Hoard's Dairyman Journal

Thoen, C.O., Steele, J. H. and Gilsdorf, M. J. 2006. Mycobacterium bovis infection in Animals and Humans. Second Edition, pp. 329, Blackwell Publishing, Ames, IA.

Helgerson, J. L., Weston, K. D., Jarnagin, J. L. and Thoen, C.O., 2006. Natural exposure of purchased heifers in Johne's positive herd. In: Proceedings of the 39th Annual Conference of American Assoc. Bovine
Practitioners, Saint Paul, MN

Thoen, C.O. 2006. Tuberculosis. In: Diseases of Swine. Eds. B. E.Straw, J. J. Zimmerman, S. D'Allaire and D. J. Taylor. Ninth edition. Chapter 49. pp. 807– 816. Blackwell, Publishing, Ames, IA

Robbe-Austerman, S., Gardner, I. A, Thomsen, B. V., Morrical, D. G., Martin, B. M., Palmer, M. V., Thoen, C. O. and Ewing, C. E. 2006. Sensitivity and specificity of the agar-gel-immunodiffusion test, ELISA and the skin test for detection of paratuberculosis in United States Midwest sheep populations. Vet. Res. 37: 553- 564.

Thoen, C.O. and Ebel, E. D. 2006. Diagnostic Tests for Bovine Tuberculosis. In: Mycobacterium bovis Infection in Animals and Humans, Chapter 6. pp. 49-53, Blackwell, Publishing, Ames, IA

Thoen, C.O. 2005. Tuberculosis. The Merck Veterinary Manual. Ed. Cynthia Kahn. pp. 549 - 555. Merck and Co. Inc. Whitehouse Station, NJ.

Thoen, C.O. and Barletta, R. 2004. Mycobacterium. In: Pathogenesis of Bacterial Infections in Animals. Editors: C. L. Gyles, J. F. Prescott, J. G. Songer, C. O. Thoen. Third Edition. Chapter 6. pp 69 – 76. Blackwell
Publishing, Ames, IA.

Kaneene, J.and Thoen, C.O. 2004. Tuberculosis. Invited. Zoonosis Updates. Jour. Amer. Vet. Med.Assoc. 224:695 -691.

Olsen, S. C., Thoen, C. O. and Cheville, N. F. 2004. Brucella. In: Pathogenesis of Bacterial Infections in Animals. Eds. C. L. Gyles, J. F. Prescott, J. G. Songer and C. O. Thoen. Chapter 22. pp. 309-319. Wiley/Blackwell Publisher Ames, IA

Fulton, R. M. and Thoen, C. O. 2003. Tuberculosis. In: Diseases of Poultry. pp. 836-844. Iowa State Press. Ames, IA.

Steadham, E.M., Martin, B.M., and Thoen, C.O. 2002. Production of a Mycobacterium avium ssp. paratuberculosis purified protein derivative (PPD) and evaluation of potency in guinea pigs. Biologicals. 30:93-95.

Kaneene, J.B., Bruning-Fann, C.S., Dunn, J., Mullaney, T.P., Berry, D., Massey, J.P., Thoen, C.O., Halstead, S., and Schwartz, K. 2002. Epidemiologic investigation of Mycobacterium bovis in a population of cats. Am.Jour.Vet.Res. 11: 1507-1511.

Thoen, C.O. and Garcia-Marin, J.F. 2002. Mycobacterium. Invited. Animal Health and Production Compendium. CAB International..

Mikota, S.K., Peddie, L., Peddie, J., Issasa, R., Thoen, C.O., et al. 2001. Epidemiology and Diagnosis of Mycobacterium tuberculosis in elephants. Journal of Zoo Wildlife Medicine. 32(1): 1 -16.

Just, S.D., Thoen, C.O., Thacker, B.J., Thomson, J.U. 2001. Monitoring of Lawsonia intracellularis by indirect serum immunofluorescence assay in a commercial swine production system. Journal of Swine Health Production. 9(2):57-61.

Gilsdorf, M.J., Thoen, C.O., Temple, R.M.S. et al. 2001. Experimental exposure of llamas (Lama glama) to Brucella abortus: Humoral antibody response. Vet. Microbiol. 81:85-91.

Capsel, R.L., Olsen, S.C., Cheville, N.F., Thoen, C.O. 2000. Survival of Brucella abortus Strain RB51 lyophilized and as liquid vaccine under different storage conditions. Biologicals 28:209-215.

Hornsby, R.L., Jensen, A.E., Olsen, S.B., Thoen, C.O. 2000. Selective Media for Isolation of Brucella abortus strain RB51. Vet. Microbiol. 43:51-60.

President, American Veterinary Epidemiology Society, American Veterinary Medical Association

Editor in Chief – Veterinary Science Research

Associate Editor, The International Journal of Tuberculosis and Lung Disease: 2002 to present.

Editor, Mycobacterium bovis Infection in Animals and Humans.  2006. Second Edition,  Blackwell Publishing.

Senior Editor, Pathogenesis of Bacterial Infections.  2010.  Fourth Edition.  Blackwell Publishing, Ames

Chair, Department of Veterinary Microbiology, College of Veterinary Medicine, ISU.  1998 -2001.

Chair, Admissions Committee, College of Veterinary Medicine, 2000 to 2007

Chair, Scientific Committee on Tuberculosis in Animals, International Union Against Tuberculosis and Lung Disease. 1997-2005.

Chair, Committee on Animal Tuberculosis. World Health Organization. 1996-1999

National Tuberculosis Advisory Committee for Zoo Animals
National Johne's Working Group - member
International Elephant Foundation Tuberculosis Advisory Panel - member
National Johne's Integrated Program - member

American Veterinary Medical Association - Karl F. Meyer - James H. Steele Gold Cane Award, (2009).

Iowa Board of Regents - Award for Faculty Excellence  1999.

American Veterinary Epidemiology Society - Honary Diplomate,  2005.

Iowa State University - Outstanding Academic Advisor, 1996.

One Health/One Medicine

American Veterinary Medical Association

International Union Against Tuberculosis and Lung Disease

American Veterinary Epidemiology Society

American Society for Microbiology

Conference Research Workers in Animal Disease

American Association of Veterinary Laboratory Diagnosticians

United States Animal Health Association. Member of the following committees: 
a.) Paratuberculosis, b.) Tuberculosis, c.) Infectious Diseases of bison, llama and cattle, d.) Wildlife Disease, and e.) Alternate Species

Iowa Veterinary Medical Association

Minnesota License to practice Veterinary Medicine