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Charles O Thoen

Charles Thoen
Charles O. Thoen

DVM, PhD., Diplomate AVES

Professor
Vet Microbiology & Preventive Medicine
(515) 294-7608
2152 Vet Med
Expertise / Research Area

Dr. Thoen conducts investigations on the pathogenesis of Mycobacterium bovis, M. tuberculosis, M. avium ss paratuberculosis, M. avium ss avium and M. avium ss intracellulare in domestic and captive wild animals. The focus of research is to provide an improved understanding of host immune responses that can be used in developing more reliable in vivo and in vitro diagnostic tests.

Teaching

Infectious Diseases of Captive Wild Animals -- VMPM 409 - Instructor
Zoonosis -- VMPM 536 (Graduate Course) - Instructor in Charge
Zoo Medicine Preceptorship -- VMPM 494 - Instructor in Charge
Wild Animal Health and Conservation -- VMPM 496 -- Instructor in Charge
Medical Bacteriology - VMPM 586 - Lecturer
Public Health for Veterinary Medical Students - VMPM 388 - Lecturer
 

Education

D.V.M.: University of Minnesota, 1961.
Ph.D.: University of Minnesota, Mayo Graduate School of Medicine, 1971.
Honorary Diplomate: American Veterinary Epidemiology Society, 2005

Selected Publications

Texbooks:

 

Zoonotic Tuberculosis: Mycobacterium bovis and other pathogenic mycobacteria. 2014. C. O. Thoen, J. H. Steele & J. B. Kaneene. Wiley-Blackwell Publishing. In Press.

Pathogenesis of Bacterial Infections in Animals. 1986, 1993, 2006, & 2010. Gyles, C. L., Prescott, J. F., Songer, J. G. and Thoen, C.O. Wiley/Blackwell Publishing

Mycobacterium bovis Infection in Animals and Humans. First Ed. (1995): Second Ed. (2006).
Thoen, C.O., Steele, J.H. and Gilsdorf, M. J. Blackwell Publishing
 

 

Selected from more than 300 refereed publications.

Thoen, C. O. and Barletta R. G. 2014. Pathogenesis of tuberculosis caused by Mycobacterium bovis. In: Zoonotic Tuberculosis: Mycobacterium bovis and other pathogenic mycobacteria. Edited by - C. O. Thoen, J. H. Steele and J. B. Kaneene. Wiley-Blackwell Publishing. In press.

Thoen, C. O. LoBue, P. A. and Enerson, D. A. 2014. Tuberculosis in Animals and Humans. In: Zoonotic Tuberculosis: Mycobacterium bovis and other pathogenic mycobacteria. Edited by - C. O. Thoen, J. H. Steele and J. B. Kaneene. Wiley-Blackwell Publishing. In press.

Frost, P. A., Calle, P., Klein, H. and Thoen, C. O. 2014. Tuberculosis in Non-Human Primates. In: Zoonotic Tuberculosis: Mycobacterium bovis and other pathogenic mycobacteria. Edited by - C. O. Thoen, J. H. Steele and J. B. Kaneene. Wiley-Blackwell Publishing. In press.

West, G. and Thoen, C. O. 2014. Tuberculosis in Elephants. In:  Infectious Diseases of Concern to Captive and Free Ranging Animals in North America.  Eds. K, C. Gamble and M. M. Clancy. Published by American Association of Zoo Veterinarians and the European Association of Zoo and Wildlife Veterinarians. (In Press).

Kanenee, J. B., Kaplan, B. Steele, J. H. and Thoen, C. O 2014.  One Health Approach to Controlling Tuberculosis in Animals and Humans.  In: Zoonotic Tuberculosis: Mycobacterium bovis and other mycobacterial infections. Chapter 2. Wiley-Blackwell Publishing, Ames, IA. (In Press).

Frost, P., Cole, H. and Thoen, C. O.  2011 & 2014.  Tuberculosis in Non-human Primates. In:  Infectious Diseases of Concern to Captive and Free Ranging Animals in North America.  Eds. K, C. Gamble and M. M. Clancy. Published by American Association of Zoo Veterinarians and the European Association of Zoo and Wildlife Veterinarians. (In Press).

Armstrong, D. and Thoen, C. O.  2011, 2014. Tuberculosis in Ungulates.  In:  Infectious Diseases of Concern to Free Ranging Animals in North America.  Eds. K. C. Gamble and M. M. Clancy.  Published by American Association of Zoo Veterinarians and European Association of Zoo and Wildlife Veterinarians. (In Press).

Thoen, C. O. and Kanenee, J. B. 2013. The Role of mycobacteria in Food Safety. In: Food Associated Pathogens. Eds. W. Tham and M. L. Danielson. Chapter 12. pp. 156-168. CRC Press, Boca Raton, FL.

Thoen, C. O. and Beran, G.W. 2012. Effect of Electron Beam Irradiation on Mycobacterium avium complex in ground pork. Intern. Jour. Tuberculosis & Lung Disease. 16 (8): 1134-1135

Thoen, C. O. 2012. Tuberculosis. In: Diseases of Swine. Edited by – J. Zimmerman, L. Karriker, A. Ramirez, K.J. Schwartz and G.W. Stevenson. Tenth Edition pp. 656-865 Wiley/Blackwell Publishing

Thoen, C. O., LoBue, P. and de Kantor, I. 2010.  (Invited).  Why has Zoonotic Tuberculosis not received much attention? International Journal Tuberculosis and Lung Disease 14(9):1073-1074

de Kantor, I. N., LoBue, P. A. and Thoen C. O. 2010. Human Tuberculosis Caused by Mycobacterium bovis in the United States, Latin America, and the Caribean. EDUCATIONAL SERIES: Mycobacterium bovis. International Journal on Taberculosis and Lung Disease 14(11):1369-1373

Kaneene, J. B., Miller R. A., deKantor I. N. and Thoen C. O. 2010. Tuberculosis in Wild Animals. EDUCATIONAL SERIES: Mycobacterium bovis. International Journal on Taberculosis and Lung Disease 14(12): 1508-1512

Thoen, C.O. 2010.  Tuberculosis and other mycobacterial diseases In: Merck Veterinary Manual, Tenth Edition. Ed. Cynthia Kahn & S. Line, Merck and Co. Inc. Whitehouse Station N.J.

Qual, D. A., Kaneene, J. B., Varty, T. J., Miller, R. and Thoen, C. O. 2010. Lack of association between the occurrence of Crohn's disease and occupational exposure to dairy and beef cattle herds infected with Mycobacterium avium subspecies paratuberculosis. Journal Dairy Science 93:2371-2376.

Platt, R., Thoen, C. O., Stahberger, R. J., Chiang, Y. W., Roth, J. A. 2010. Evaluation of the cell-mediated immune response to reduced doses of Mycobacterium avium ssp. paratuberculosis vaccine in cattle.  Veternary Immunology and Immunopathology 136 (1-2): 122-126.

LoBue, P., Enarson, D. A., and Thoen, C. O. 2010, Tuberculosis in humans and animals: An Overview. EDUCATIONAL SERIES: Mycobacterium bovis. International Journal Tuberculosis and Lung Disease 14(9): 1075-1078 (Invited)

Thoen, C. O., LoBue, P. A., Enarson, D. L., Kaneene, J. and de Kantor, I. 2009.  (Invited). Tuberculosis: a reemerging disease in animals and humans.  Vet. Italiania 45(1): 135-181

Olsen S. C., Bellaire, B.H., Roop, R.M.II and Thoen, C. O. 2010. Brucella, In: Pathogenesis of Bacterial Infections in Animals. pp. 429-442 Fourth Edition, Ed. by C.L. Gyles, J.F. Prescott, J.G. Songer and C. O. Thoen Wiley/Blackwell Ames, IA

Thoen, C.O., Williams, D. E. and Thoen, T. C. . 2008 (Invited). Discovery of Streptomycin for the Treatment of Tuberculosis. One Health Newsletter. 1(3): 5-6

Olsen, I. Barletta, R. & Thoen, C. O., 2010.  Mycobacterium. In: Pathogenesis of Bacterial Infections in Animals. In: Pathogenesis of Bacterial Infections in Animals. Fourth Edition, pp. 113-132 Ed. by C.L. Gyles, J.F. Prescott, J.G. Songer and C.O. Thoen, Wiley/Blackwell Publisher

Wilkins, M.J. Bartlett, P. C., Berry, D. E., Perry, R. L. Fitzgerald, S. D., Bernardo, T. M., Thoen, C. O. and Kaneene, J. B. 2008. Absence of Mycobacterium bovis infection in dogs and cats residing on infected cattle farms: Michigan, 2002. Epidemiol. Infect. 1:1-7.

Thoen, C. O. and LoBue, P. A. 2007 (Invited). Mycobacterium bovis tuberculosis: Forgotten, but Not Gone. Lancet 369(9569):1236-1238

Thoen, C. O., 2007. Johne's Disease. In: McGraw-Hill Encyclopedia of Science and Technology ed. L. Geller. Tenth Edition. McGraw-Hill Professional New York 9:515-516

Thoen, C.O. and Barletta, R. 2006. Pathogenesis of Mycobacterium bovis. In. Mycobacterium bovis Infection in Animals and Humans. Eds. C. O.Thoen, J. H. Steele and M. J. Gilsdorf. Chapter 4. pp 18-33. Blackwell Publishing, Ames, IA

Platt, R., Roth, J. A., Royer, R. L. and Thoen, C. O. 2006. Monitoring responses by use of five-color flow cytometry in subsets of peripheral T cells obtained from cattle inoculated with a killed Mycobacterium avium
subsp paratuberculosis vaccine. Amer. Jour. Vet. Res. 67(12): 2050 - 2058

Thoen, C.O., LoBue, P. A. and de Kantor, I. 2006. The importance of Mycobacterium bovis as a Zoonosis. Vet. Microbiol. 112: 339 – 345.

Thoen, C. O., Robbe-Austerman, S., Whitlock, R. H., Hoards Rubl. 2006. Don't overlook vaccination for control of Johne's. p. 666, Hoard's Dairyman Journal

Thoen, C.O., Steele, J. H. and Gilsdorf, M. J. 2006. Mycobacterium bovis infection in Animals and Humans. Second Edition, pp. 329, Blackwell Publishing, Ames, IA.

Helgerson, J. L., Weston, K. D., Jarnagin, J. L. and Thoen, C.O., 2006. Natural exposure of purchased heifers in Johne's positive herd. In: Proceedings of the 39th Annual Conference of American Assoc. Bovine
Practitioners, Saint Paul, MN

Thoen, C.O. 2006. Tuberculosis. In: Diseases of Swine. Eds. B. E.Straw, J. J. Zimmerman, S. D'Allaire and D. J. Taylor. Ninth edition. Chapter 49. pp. 807– 816. Blackwell, Publishing, Ames, IA

Robbe-Austerman, S., Gardner, I. A, Thomsen, B. V., Morrical, D. G., Martin, B. M., Palmer, M. V., Thoen, C. O. and Ewing, C. E. 2006. Sensitivity and specificity of the agar-gel-immunodiffusion test, ELISA and the skin test for detection of paratuberculosis in United States Midwest sheep populations. Vet. Res. 37: 553- 564.

Thoen, C.O. and Ebel, E. D. 2006. Diagnostic Tests for Bovine Tuberculosis. In: Mycobacterium bovis Infection in Animals and Humans, Chapter 6. pp. 49-53, Blackwell, Publishing, Ames, IA

Thoen, C.O. 2005. Tuberculosis. The Merck Veterinary Manual. Ed. Cynthia Kahn. pp. 549 - 555. Merck and Co. Inc. Whitehouse Station, NJ.

Thoen, C.O. and Barletta, R. 2004. Mycobacterium. In: Pathogenesis of Bacterial Infections in Animals. Editors: C. L. Gyles, J. F. Prescott, J. G. Songer, C. O. Thoen. Third Edition. Chapter 6. pp 69 – 76. Blackwell
Publishing, Ames, IA.

Kaneene, J.and Thoen, C.O. 2004. Tuberculosis. Invited. Zoonosis Updates. Jour. Amer. Vet. Med.Assoc. 224:695 -691.

Olsen, S. C., Thoen, C. O. and Cheville, N. F. 2004. Brucella. In: Pathogenesis of Bacterial Infections in Animals. Eds. C. L. Gyles, J. F. Prescott, J. G. Songer and C. O. Thoen. Chapter 22. pp. 309-319. Wiley/Blackwell Publisher Ames, IA

Fulton, R. M. and Thoen, C. O. 2003. Tuberculosis. In: Diseases of Poultry. pp. 836-844. Iowa State Press. Ames, IA.

Steadham, E.M., Martin, B.M., and Thoen, C.O. 2002. Production of a Mycobacterium avium ssp. paratuberculosis purified protein derivative (PPD) and evaluation of potency in guinea pigs. Biologicals. 30:93-95.

Kaneene, J.B., Bruning-Fann, C.S., Dunn, J., Mullaney, T.P., Berry, D., Massey, J.P., Thoen, C.O., Halstead, S., and Schwartz, K. 2002. Epidemiologic investigation of Mycobacterium bovis in a population of cats. Am.Jour.Vet.Res. 11: 1507-1511.

Mikota, S.K., Peddie, L., Peddie, J., Issasa, R., Thoen, C.O., et al. 2001. Epidemiology and Diagnosis of Mycobacterium tuberculosis in elephants. Journal of Zoo Wildlife Medicine. 32(1): 1 -16.

Just, S.D., Thoen, C.O., Thacker, B.J., Thomson, J.U. 2001. Monitoring of Lawsonia intracellularis by indirect serum immunofluorescence assay in a commercial swine production system. Journal of Swine Health Production. 9(2):57-61.

Gilsdorf, M.J., Thoen, C.O., Temple, R.M.S. et al. 2001. Experimental exposure of llamas (Lama glama) to Brucella abortus: Humoral antibody response. Vet. Microbiol. 81:85-91.

Capsel, R.L., Olsen, S.C., Cheville, N.F., Thoen, C.O. 2000. Survival of Brucella abortus Strain RB51 lyophilized and as liquid vaccine under different storage conditions. Biologicals 28:209-215.

Hornsby, R.L., Jensen, A.E., Olsen, S.B., Thoen, C.O. 2000. Selective Media for Isolation of Brucella abortus strain RB51. Vet. Microbiol. 43:51-60.

 

Leadership

President, American Veterinary Epidemiology Society, American Veterinary Medical Association - 2011 to present

Editor, Zoonotic Tuberculosis: Mycobacterium bovis and other pathogenic mycobacteria. (In Press) 2014

Editor in Chief – Veterinary Science Research

Associate Editor, The International Journal of Tuberculosis and Lung Disease: 2002 to present

Editor, Mycobacterium bovis Infection in Animals and Humans.  2006. Second Edition,  Blackwell Publishing

Senior Editor, Pathogenesis of Bacterial Infections.  2010.  Fourth Edition.  Blackwell Publishing, Ames

Editor, European Journal of Veterinary Medicine 

Chair, Department of Veterinary Microbiology, College of Veterinary Medicine, ISU.  1997 -2001

Chair, Admissions Committee, College of Veterinary Medicine, 2000 to 2007

Chair, Scientific Committee on Tuberculosis in Animals, International Union Against Tuberculosis and Lung Disease. 1997-2005

Chair, Committee on Animal Tuberculosis. World Health Organization. 1996-1999

Member, United States Animal Health Association committees on tuberculosis, wildlife disease, paratuberculosis, and wild animals. 1997-Present

Honors & Awards

American Veterinary Medical Association - Karl F. Meyer - James H. Steele Gold Headed Cane Award, (2009).

Iowa Board of Regents - Award for Faculty Excellence  1999.

American Veterinary Epidemiology Society - Honary Diplomate,  2005.

Iowa State University - Outstanding Academic Advisor, 1996.

Memberships

One Health/One Medicine

American Veterinary Medical Association

International Union Against Tuberculosis and Lung Disease

American Veterinary Epidemiology Society

American Society for Microbiology

Conference Research Workers in Animal Disease

American Association of Veterinary Laboratory Diagnosticians

Iowa Veterinary Medical Association

Minnesota License to practice Veterinary Medicine