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Elizabeth Whitley

Elizabeth Whitley
Elizabeth M. Whitley

DVM, PhD, Diplomate ACVP

Associate Professor of Veterinary Anatomic Pathology
Veterinary Pathology
(515) 294-9434
2716 Vet Med
Expertise / Research Area

As an anatomic pathologist-scientist-educator with expertise in comparative pathology, Dr. Whitley provides diagnostic pathology services, participates in the educational development of professional veterinary and graduate students, and investigates animal and human diseases. As a practicing diagnostic pathologist, she performs gross and microscopic examination of submitted animal tissues from a variety of companion, exotic, and production animal species. In addition to general diagnostic duties, she has special interests in ocular, pancreatic and neuropathology.

Dr. Whitley is trained in both scientific investigation and veterinary anatomic pathology. Throughout her career, she has performed both bench-top molecular techniques and used her specialized knowledge in tissue morphology to test research hypotheses. She is also a member of several trans-disciplinary research teams at Iowa State University. Using laser microdissection and molecular techniques, her laboratory is currently identifying the effects of dietary resistant starch on the regulation of proliferation and differentiation in the colonic epithelium. Other currently active research topics include the effects of dietary resistant starch on Vitamin D metabolism and epigenetic effects in diabetes; mechanisms of systemic and neurotoxicity produced by harmful algal blooms and other environmental toxins; and systemic effects and therapeutic potential of nanoparticles. As a collaborating pathologist of the Comparative Pathology Core in the Department of Pathology, she is assisting in the characterization of several inherited models.

Teaching

Veterinary Pathology 456, Senior Necropsy Practicum
Two-week block rotations through the Veterinary Pathology Diagnostic Necropsy Service, 145 fourth-year veterinary students with 6 students per block; covers concepts of pathogenesis, technical, diagnostic and communication skills required for successful veterinary practice; 1 credit course each two-week block, required course, serve as duty pathologist/instructor 9 weeks/year and Instructor-in-charge for Fall, Spring, and Summer semesters.

Veterinary Pathology 401, The Basics of Medical Terminology
Sixteen classroom sessions; ~24 undergraduate and professional students; meaning, spelling, pronunciation, use, and etymology of medical vocabulary; 1 credit, elective course, Instructor-in-charge.

Veterinary Pathology 571, Systemic Pathology
Five 2-hour lecture/laboratory sessions; 3-7 post-DVM graduate students/anatomic pathology residents; pathophysiology, gross, and histologic features of veterinary neuropathology are presented using summary and case-based material; 4 credits; Instructor.

Veterinary Pathology 604, Pathology Case Seminar
Fifteen interactive seminar sessions; 4-10 post-DVM graduate students/anatomic or clinical pathology residents, VPTH departmental faculty, visiting pathologists, 1-4 professional veterinary students; students present their description and interpretation of histopathology and clinical pathology from natural and experimental pathology cases, instructor selects cases, guides discussion, and provides critique; 1-2 credits; rotating instructor-in-charge.

Veterinary Pathology 699, Graduate Research
Individualized, focused research program for graduate students; variable credit, instructor-in-charge.

Neuroscience 557, Advanced Neuroscience Techniques
One three-hour lecture session; 6-12 Neuroscience graduate students, practical techniques for tissue handling and processing to enhance quality of histologic sections and identification of common lesions and artifacts; 2 credits; instructor.

 

 

Education

Diplomate, American College of Veterinary Pathologists, 2004
Anatomic Pathology Residency, Auburn University, Auburn AL

Ph.D., Biomedical Sciences (Tumor Immunology), 2001
Auburn University, Auburn, AL

M.S., Pathobiology (Pathology and Immunology), 1993
Auburn University, Auburn, AL
            
Doctor of Veterinary Medicine, 1988
University of Florida, Gainesville, FL

B.S., Microbiology and Cell Science, with High Honors, 1984
University of Florida, Gainesville, FL
 

Selected Publications

1. Jovanovic B, Whitley EM, Palic D.  Histopathology of fathead minnow (Pimephales promelas) exposed to hydroxylated fullerenes.  Journal of Nanotoxicology, in press, July 22, 2013. 

2. Smazal AL, Borcherding NC, Anderegg AS, Schalinske KL, Whitley EM, Rowling MJ.  Dietary resistant starch prevents urinary excretion of 25-hydroxycholecalciferol and vitamin D-binding protein in type 1 diabetic rats.  Journal of Nutrition, 143:1123-1128, 2013. 

3. Xu J, Bigelow TA, Whitley EM.  Assessment of ultrasound histotripsy-induced damage to ex vivo porcine muscle.  Journal of Ultrasound in Medicine, 32:69-82, 2013.

4. Mohammed EA, Snella EM, Rutz-Mendicino MM, Echevarria FD, Awedikian R, Whitley EM, Ellinwood NM.  Accelerated clinical disease and pathology in mucopolysaccharidosis type IIIB and GalNAc transferase double knockout mice. Molecular Genetics Metabolism, 107:129-135, 2012.

5. Zhang Y, Haage A, Whitley EM, Schneider IC, Clapp AR.  Mixed-surface, lipid-tethered quantum dots for targeting cells and tissues.  Colloids and Surfaces, B Biointerfaces, 94:27-35, 2012.

6. Burrough ER, Myers RK, Hostetter SJ, Fox LE, Bayer BJ, Felz CL, Waller KR, Whitley EM.  Amyloid deposition in two feline epithelial-predominant thymomas.  Veterinary Pathology 49:616-620, 2012.

7. Brugmann Boudreaux BL, Smith AN, Lee HP, Booth DM, Higginbotham ML, Whitley EM, Smith BF, Behrend EN.  In vitro evaluation of ABCB1 after exposure to prednisolone and enrofloxacin in two canine lymphoid cell lines: A pilot study.  International Journal of Applied Research in Veterinary Medicine, 10:31-41, 2012.

8. Boddicker RL, Whitley EM, Birt DF, Spurlock ME.  Early lesion formation in colorectal carcinogenesis is associated with adiponectin status whereas neoplastic lesions are associated with diet and sex in C57BL/6J mice.  Nutrition and Cancer, 63:1328-1338, 2011. 

9. Boddicker RL, Whitley EM, Davis J, Birt DF, Spurlock ME.  Low dose dietary resveratrol has differential effects on colorectal tumorigenesis in adiponectin knockout and wild-type mice.  Nutrition and Cancer, 63:1297-1306, 2011.

10. Parker VJ, Jergens AE, Whitley EM, Frana TS.  Isolation of Cokeromyces recurvatus from the gastrointestinal tract of a dog with protein-losing enteropathy.  Journal Veterinary Diagnostic Investigation, 23:1014-1016, 2011. 

11. Rodriguez Hurtado I, Stewart AJ, Wolfe DF, Caldwell FJ, Harrie M, Whitley EM.  Immunolocalization of the hyaluronan receptor CD44 in the reproductive tract of the mare.  Theriogenology, 75:276-286, 2011. 

12. McGraw AL, Whitley EM, Lee H, Boothe D, Behrend EN. Determination of the concentrations of trilostane and ketotrilostane that inhibit ex vivo adrenal synthesis of cortisol, corticosterone, and aldosterone.  American Journal of Veterinary Research, 72(5):661-665, 2011.

13. O’Neill AM, Smith AN,  Spangler EA, Whitley EM, Schleis SE, Bird RC, Curiel DT, Thacker EE,  Smith BF.  Resistance of canine lymphoma cells to adenoviral infection due to reduced cell surface RGD binding integrins.  Cancer Biology & Therapy, 11(7):651-658, 2011.

14. Burrough ER, Myers RA, Whitley EM:  Spontaneous odontoameloblastoma in a female Sprague-Dawley Rat.  Journal of Veterinary Diagnostic Investigation, 22:998-1001, 2010.
 

Memberships

American College of Veterinary Pathologists
American Society for Investigative Pathology
Comparative Ocular Pathology Society
Phi Zeta Veterinary Honor Society
Phi Kappa Phi Academic Honor Society