Jesse Paul Goff
Professor and Anderson Chair
2048 Vet Med
This laboratory is best known for its work on milk fever of dairy cattle. As a result much of our effort was on the transition dairy cow - the time from about 3 wks before calving until 3 wks after calving. This period represents the time of greatest risk of ilness for the dairy cow. Therefore we have been studying calcium and mineral homeostasis, immune suppression at the time of calving, and the interactions between nutrition and immunology and their effects on metabolic and infectious disease in transition dairy cows. Vitamin D insufficiency has been linked to increased predisposition to several forms of cancer as well as autoimmune disease. We are currently developing new forms of vitamin D that may effectively prevent/ treat colon cancer and inflammatory bowel disease. We have also been working with the problem of vitamin D deficiency in suckling and early weaned piglets. Dr. Nicholas Koszewski joined the lab in 2009 and has greatly advanced our ability to perform analysis of gene expression at the cellular and organismal level.
BMS 336- Veterinary Clinical Nutrition, 2 Cr hrs. Required of all 1st year professional students.
BMS 334 - Veterinary Histophysiology - teach section on Digestive Physiology
VDPAM 498 - teach section on metabolic diseases of dairy cattle. Elective for 4th year veterinary students.
BS- Cornell University, 1977
MS - Iowa State University, 1980
DVM- Iowa State University, 1984
PhD, Iowa State University, 1986
American College of Veterinary Nutrition, Honorary Diplomate, 2011
GOFF HAS OVER 135 REFEREED SCIENTIFIC PUBLICATIONS (THE LAST FIVE YEARS ONLY ARE LISTED)
Nonnecke BJ, Waters WR, Goff JP, Foote MR. Adaptive immunity in the colostrum-deprived calf: response to early vaccination with Mycobacterium bovis strain bacille Calmette Guerin and ovalbumin. J Dairy Sci. 2012 Jan;95(1):221-39.
Goff JP, Koszewski NJ, Haynes JS, Horst RL. Targeted delivery of vitamin D to the colon using β-glucuronides of vitamin D: therapeutic effects in a murine model of inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol. 2011
Reinhardt TA, Lippolis JD, McCluskey BJ, Goff JP, Horst RL.
Prevalence of subclinical hypocalcemia in dairy herds. Vet J. 2010 Apr 28.
Bannerman DD, Springer HR, Paape MJ, Kauf AC, Goff JP. Evaluation of breed-dependent differences in the innate immune responses of Holstein and Jersey cows to Staphylococcus aureus intramammary infection. J Dairy Res. 2008 Aug; 75(3):291-301.
Bannerman DD, Kauf AC, Paape MJ, Springer HR, Goff JP. Comparison of Holstein and Jersey innate immune responses to Escherichia coli intramammary infection. J. Dairy Sci. 2008 Jun; 91(6):2225-35.
Kimura K, Goff JP, Schmerr MJ, Stabel JR, Inumaru S, Yokomizo Y. Activation of immune cells in bovine mammary gland secretions by zymosan-treated bovine serum. J Dairy Sci. 2008 May; 91(5):1852-64.
Goff JP. The monitoring, prevention, and treatment of milk fever and subclinical hypocalcemia in dairy cows. Vet J. 2008 Apr;176(1):50-7.
Goff JP, Brummer EC, Henning SJ, Doorenbos RK, Horst RL. Effect of application of ammonium chloride and calcium chloride on alfalfa cation-anion content and yield. J Dairy Sci. 2007 Nov; 90(11):5159-64.
Kimura K, Reinhardt TA, Goff JP. Parturition and hypocalcemia blunts calcium signals in immune cells of dairy cattle. J Dairy Sci. 2006 Jul; 89(7):2588-95.
Lippolis, J.D., T.A. Reinhardt, J.P. Goff, and R.L. Horst. 2006. Neutrophil extracellular trap formation by bovine neutrophils is not inhibited by milk. Vet Immunol Immunopathol. 113(1-2):248-55.
Kimura, K., T.A. Reinhardt and J.P. Goff. 2006. Parturition and hypocalcemia blunts calcium signals in immune cells of dairy cattle. J. Dairy Sci. 89(7):2588-95.
Hammon, D.S., I.M. Evjen, T.R. Dhiman, J.P. Goff, and J.L. Walters. 2006. Neutrophil function and energy status in Holstein cows with uterine health disorders. Vet Immunol Immunopathol. 113(1-2):21-9.
Goff, J.P. 2006. Major advances in our understanding of nutritional influences on bovine health. J. Dairy Sci. 89(4):1292-301.
Melendez, P., J.P. Goff, C.A. Risco, L.F. Archbald, R.C. Littell, and G.A. Donovan. 2006. Effect of administration of a controlled-release monensin capsule on incidence of calving-related disorders, fertility, and milk yield in dairy cows. Am. J. Vet. Res. 67(3):537-43.
Melendez, P., J.P. Goff, C.A. Risco, L.F. Archbald, R. Littell, and G.A. 2006. Donovan. Incidence of subclinical ketosis in cows supplemented with a monensin controlled-release capsule in Holstein cattle, Florida, USA. Prev. Vet. Med. 73(1):33-42.
Harp, J.A., T.E. Waters, J.P. Goff, D.D. Bannerman, and M.J. Paape. 2006. Expression of lymphocyte homing and adhesion molecules during intramammary infection of cows with Serratiamarcescens or Streptococcusuberis: correlation with bacterial colonization and clinical signs. Vet Immunol Immunopathol. 109(1-2):13-21.
Biomedical Sciences Governance Committee
CVM Academic Standards Committee
ISU Academic Standards Committee
Dr. Goff has received several formal honors and awards during his career. Goff currently holds the Anderson Chair in Veterinary Medicine.
· USDA-ARS Early Career Scientist Award, 1991
· In 1993, Dr. Goff received a grant from the National Research Initiative (NRI) for a proposal to test the effects of dietary Ca and potassium on the incidence of milk fever. The studies funded by this grant were chosen by the administrating officers of the National Research Initiative program as a “National Research Initiative Highlight.” In 1997 The NRI Program staff cited this study as exemplary of the type of good science the NRI can fund that will impact positively on American agriculture.
· 1998 Goff was recipient of the American Feed Industry Association Award for “Outstanding Contributions in the Field of Dairy Cattle Nutrition Research” awarded at the 1998 American Association of Dairy Science Association meeting.
· In 2001, Dr. Goff was appointed to the National Research Council’s Committee on Animal Nutrition. This branch of the National Academy of Sciences oversees projects related to publication of guides on the nutrition of all animal species. It also examines issues of importance to animal agriculture including writing white papers on various subjects. Dr. Goff served on this committee for three years, 2001-2004.
· Dr. Goff received the “Nutrition Professionals “ award for “Outstanding contributions in the field of practical dairy nutrition at the 2005 American Dairy Science Association meeting.
· 2011 - Iowa State University Student Chapter of American Veterinary medical Association Teaching Award – given by the students to the outstanding teacher in the basic sciences of the professional curriculum.
· 2011 - Iowa State University College of Veterinary Medicine Norden Teaching Award – given to the most outstanding faculty member teaching in the veterinary professional curriculum.
American Dairy Science Association
American Association of Bovine Practitioners
American Association of Swine Veterinarians
Iowa Veterinary Medical Association