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Shannon Jones Hostetter

Shannon Hostetter
Shannon Jones Hostetter

DVM, PhD, Diplomate ACVP

Assistant Professor
Veterinary Pathology
(515) 294-0952
1790 E-1 Vet Med
Expertise / Research Area

Dr. Shannon Hostetter's work is in the role of Shiga toxin (Stx) production and dissemination in proinflammatory cytokine alterations observed in clinically-affected patients. Hemolytic uremic syndrome (HUS), a systemic complication of Shiga toxin-producing Escherichia coli (STEC) infection, is the number one cause of renal failure in children in the United States. The goals are to 1) clarify the role of Stx in inflammation during Shiga toxin-producing Escherichia coli (STEC) infection 2) identify specific interactions between Stx and neutrophils to assess the potential role of this leukocyte in Stx transport during STEC infection and 3) assess the efficacy of an oral Stx-binding agent at preventing systemic disease following STEC inoculation. The animal model used is edema disease of swine, a naturally occurring STEC disease of weaned swine caused by host-adapted strains of E. coli. Experimentally infected swine are colonized in the intestinal tract and approximately 30% of individuals develop clinical edema disease manifested by neurological symptoms due to systemic Shiga toxemia. Edema disease has been used as an animal model to study HUS based on the similar pathogenesis between the two diseases.

Dr. Hostetter is also interested in comparative clinical pathology, and is currently working with several other investigators to analyze/interpret clinical pathology samples for their research studies. 

Teaching

Introduction to Veterinary Cytology and Laboratory Techniques (VPTH 409), 1 credit required professional course (VM3), instructor/lecturer for 6 lecture/labs (12 hours total lecture/lab time), Instructor, Spring 2010.  Instructor in charge.

Clinical Pathology (VPTH 425), 4 credit required professional course (VM2). 6 contact hours weekly.  Main clinical pathology course for the veterinary students in which they learn principles of diagnostic testing and interpretation of laboratory data.  Approximately 120 ISU students enrolled, course telelinked to University of Nebraska Lincoln with an additional 24 students enrolled.  Instructor in charge. 

Clinical Pathology Laboratory Practicum (VPTH 457), 1 credit, year round.  Required rotation in 4th year of professional curriculum.  Instructor for rotation, 5-6 students per rotation block.

Pathology Case Seminar (VPTH 604), 1 credit, 2-5 students (Veterinary Pathology Residents) average, offered every fall and spring.  Case contributor/lecturer for clinical pathology cases (cytology, hematology, or clinical chemistry).  Semesters taught: Fall 09, Spring 10, Fall 10, Fall ‘11.

Independent Study in Clinical Pathology (VPTH 490x), 2 credits (one rotation block),  4th year professional student.  Intensive one on one study in clinical chemistry, hematology and cytology, with emphasis on diagnostic interpretation.  60 contact hours per rotation.

 

Education

 

A. Education

          1994, Washington and Lee University, B.S. Biology, magna cum laude

          2000, Iowa State University, D.V.M.

          2009, Iowa State University, Ph.D. and residency in Veterinary Pathology

 

B. Specialty Certifications

2009 Diplomate American College of Veterinary Pathologists – Clinical Pathology

 

Selected Publications

         

Hostetter SJ, Helgerson AF, Paton JC, Paton AW, and Cornick NA.  Therapeutic use of a receptor mimic probiotic reduces intestinal Shiga toxin levels in a piglet model of hemolytic uremic syndrome.  BMC Research Notes. Jun 2;7:331. 2014. 

Derscheid RJ, van Geelen A, Gallup JM, Hostetter SJ, Botond B, McCray PB, and Ackermann MR.  Increased concentration of iodide in airway secretions is associated with reduced RSV disease severity.  Am J Respir Cell Mol Biol. 50(2):389-97. 2014.    

Griffith RW, Yeager MJ, Hostetter SJ, Tell LA, Wetzlich SE, Vickroy T, Lillie BA, MacFarlane WB, Laudenslager TL, Whitley E, Dzikamunhenga RS, and Larson WR.  Target animal safety of fenbendazole in Chinese ring-necked pheasants (Phasianus colchicus). Avian Diseases. 58(1):8-15. 2014.

Grosz DD, van Geelen A, Gallup JM, Hostetter SJ, Derscheid RJ and Ackermann MR.  Sucrose stabilization of respiratory syncytial virus (RSV) during nebulization and experimental infection.  BMC Research Notes.  Mar 18;7:158. 2014. 

Derscheid RM, Gallup JM, Knudson CJ, Varga S, Grosz DD, van Geelen A, Hostetter SJ and Ackermann MR.  Effects of formalin-inactivated respiratory syncytial virus (FI-RSV) in the perinatal lamb model of RSV.  PLoS ONE.  Dec 6:8(12)e81472. 2013.

Burrough ER, Myers RK, Hostetter SJ, Fox LE, Bayer BJ, Felz CL, Waller KR, and Whitley E.  Amyloid deposition in 2 feline thymomas.  Veterinary Pathology. 49(4):616-20. 2012.

          Phi Beta Kappa Honor Society, 1993

          Recipient, Premium for Academic Excellence (PACE) Award, Iowa State University, 1998

          Phi Zeta Veterinary Medical Honor Society, 2005

          Recipient, C.L. Davis Student Scholarship Award, 2006

          Phi Kappa Phi Honor Society, 2007

          Recipient, SCAVMA Teaching Excellence Award in the Basic Sciences, 2012

 

 

 

 

Memberships

Member, American College of Veterinary Pathologists

Member, American Society for Veterinary Clinical Pathology