Incidence of aldosterone breakthrough (ABT) in client-owned dogs receiving angiotensin converting enzyme-inhibitors (ACEI) and/or angiotensin II receptor blockers (ARB) for proteinuric chronic kidney disease (CKDP)

Area of Study: 
Internal Medicine

Purpose of Study: 
  1. To determine the incidence of aldosterone breakthrough in dogs being given an angiotensin converting enzyme inhibitor and/or an angiotensin receptor blocker for the management of proteinuric renal disease.
  2. To determine if dogs with aldosterone breakthrough have a poorer therapeutic response.

To qualify for this study: 

1. Your dog has been diagnosed with a kidney disease primarily affecting the glomerulus (the filtering portion of the kidney), and that is unlikely to be due to a concurrent disease outside the kidney.

2. Your dog’s urine protein:creatinine ratio (a test which measures the amount of protein in the urine) of two separate urines must have an average of greater than 1.0.

3. Your dog has had two urinalyses to assure there is not urinary tract inflammation or hemorrhage that could be contributing to the urine protein content.

4. You agree to make every effort possible to return to ISU’s Lloyd Veterinary Medical Center for 4 recheck examinations at pre-determined intervals.

Client Responsibilities: 

At the initial evaluation your dog will have basic blood and urine testing, including:

  • Complete blood count 
  • Serum chemistry profile 
  • Urinalyses (2)
  • Urine protein:creatinine ratio (2)
  • Urine culture
  • Urine aldosterone:creatine ratio
  • Systolic blood pressure measurement

This is to determine your dog's overall health and to confirm the presence and severity of glomerular disease. 

Based on your dogs evaluation, he/she may be administered an angiotensin-converting enzyme inhibitor (ACEi) and /or an angiotensin receptor blocker (ARB).

Your dog will return for a recheck at 1 month, then at 2, 4, and 6 months.

During those rechecks, the following tests will be performed:

  • Urinalysis
  • Urine protein:creatinine ratio
  • Urine aldosterone:creatinine ratio
  • Serum biochemistry profile
  • Complete blood count
  • Systolic blood pressure
Client Benefits: 

The procedures listed above in your initial evaluation and rechecks will be paid for by the study up to a maximum of $895.