{"id":229,"date":"2015-08-31T16:08:11","date_gmt":"2015-08-31T16:08:11","guid":{"rendered":"https:\/\/vetmed.iastate.edu\/vpath\/vpath-comparative-pathology-core-cpc-research-services\/"},"modified":"2026-02-23T21:09:43","modified_gmt":"2026-02-23T21:09:43","slug":"vpath-comparative-pathology-core-cpc-research-services","status":"publish","type":"page","link":"https:\/\/vetmed.iastate.edu\/vpath\/services\/vpath-comparative-pathology-core-cpc-research-services\/","title":{"rendered":"VPATH Comparative Pathology Core (CPC) Research Services"},"content":{"rendered":"\n\n<div\n\tclass=\"paragraph-widget paragraph-widget--text-html\">\n\t<div class=\"text-content\">\n\t\t<p>The CPC provides pathology support for <strong>research projects involving animal models<\/strong>. This includes gross and microscopic pathology, clinical pathology, special imaging, photography and data analysis. The CPC provides service to investigators both within and outside Iowa State University and can assist with a broad range of preclinical studies in a wide range of species. Studies that CPC has completed include toxicology, vaccine studies, infectious disease, nutritional physiology, neoplastic disease, musculoskeletal disease and developmental disorders.<\/p>\n<h2><strong>Mission<\/strong><\/h2>\n<p>Provide high quality pathology support to researchers using animal models.<\/p>\n<h2><strong>Services<\/strong><\/h2>\n\n\t<\/div>\n<\/div>\n\n\n<div\n\tclass=\"paragraph-widget paragraph-widget--multicolumn-content\">\n\t<div class=\"multi-column-content multi-column-content-two-col\">\n\t\t\t\t\t<div class=\"multi-column-content__column\">\n\t\t\t\t<div class=\"text-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div><h3>Pathology<\/h3>\n<div class=\"wd-Grid--2co1\">\n<div class=\"wd-Grid-cell\">\n<ul>\n<li>Gross examination<\/li>\n<li>Tissue collection<\/li>\n<li>Gross lesion scoring<\/li>\n<li>Histopathology<\/li>\n<li>Microscopic lesion scoring<\/li>\n<li>Special stains<\/li>\n<\/ul>\n<h3><a href=\"https:\/\/vetmed.iastate.edu\/vpath\/services\/diagnostic-services\/clinical-pathology-diagnostic-and-research-services\/\">Clinical Pathology<\/a><\/h3>\n<ul>\n<li>CBC and serum biochemical analysis<\/li>\n<li>Cytologic examination<\/li>\n<li>Urinalysis<\/li>\n<\/ul>\n<\/div>\n<div class=\"wd-Grid-cell\"><\/div>\n<\/div>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<div class=\"multi-column-content__column\">\n\t\t\t\t<div class=\"text-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div><h3>Special Imaging<\/h3>\n<ul>\n<li>Immunohistochemistry\n<ul>\n<li>Fluorescence<\/li>\n<li>Chromogenic<\/li>\n<\/ul>\n<\/li>\n<li>In Situ Hybridization \u2013 RNAscope<\/li>\n<li>Hyperspectral microscopy<\/li>\n<\/ul>\n<h3>Photography<\/h3>\n<ul>\n<li>Gross and microscopic images<\/li>\n<li>Fluorescent and chromogenic IHC<\/li>\n<li>Formatting for publication<\/li>\n<\/ul>\n<h3>Data Analysis and Report Generation<\/h3>\n<ul>\n<li>HALO Image Analysis software<\/li>\n<li>Morphometrics<\/li>\n<\/ul>\n<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t<\/div>\n<\/div>\n\n\n<div\n\tclass=\"paragraph-widget paragraph-widget--text-html\">\n\t<div class=\"text-content\">\n\t\t<p><em><strong>Important Note<\/strong>: This is not a GLP laboratory. If any of the data derived from testing will be submitted to FDA, CVB, EPA, NCI or another federal agency, you are required to notify us of the agency and present the applicable regulations to our laboratory. Data from CPC may not be submitted for safety\/efficacy to FDA, CVB, EPA, NCI, or other federal agencies.<\/em><\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n\n\t<\/div>\n<\/div>\n\n\n<div\n\tclass=\"paragraph-widget paragraph-widget--image-grid-with-text\">\n\t<div class=\"image-grid-with-text\">\n\t\t<div class=\"image-grid-with-text__content text-content\">\n\t\t\t\t\t\t\t<h2>Featured Service<\/h2>\t\t\t\t\t\t\t<div><h3><strong>In Situ Hybridization &#8211; RNAscope<\/strong><\/h3>\n<p>This is a new method for in situ hybridization that yields a strong, specific, readable signal (see figures on right) using formalin fixed \/ paraffin embedded or frozen\u00a0 tissues. Species specific probes can be designed for multiple species including bovine, porcine, canine, equine and murine. Please contact us to find out if this technology may be helpful in your research project.<\/p>\n<\/div>\t\t\t\t\t<\/div>\n\t\t<div class=\"image-grid\">\n\t\t\t\t\t\t\t<div class=\"image-grid__image\">\n\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/vetmed.iastate.edu\/vpath\/wp-content\/uploads\/RNAscope-image-grid.jpg\"\n\t\t\t\t\t\t\t alt=\"RNA scope\" width=\"627\" height=\"418\"\/>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t<div class=\"image-grid__image\">\n\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/vetmed.iastate.edu\/vpath\/wp-content\/uploads\/RNAscope-singlecolor_123.png\"\n\t\t\t\t\t\t\t alt=\"RNA scope single color\" width=\"303\" height=\"202\"\/>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t<div class=\"image-grid__image\">\n\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/vetmed.iastate.edu\/vpath\/wp-content\/uploads\/RNAscope-twocolor_123.png\"\n\t\t\t\t\t\t\t alt=\"RNA Scope two-color\" width=\"303\" height=\"202\"\/>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t<div\n\t\t\t\t\tclass=\"image-grid__caption\"><p><em>Left:<\/em>\u00a0RNAscope single color ISH for porcine Il-\u03b2.\u00a0<em>Right:<\/em>\u00a0RNAscope two color for ISH for \u03b3\u03b4T cells and TGF-\u03b2<\/p>\n<\/div>\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div\n\tclass=\"paragraph-widget paragraph-widget--text-html\">\n\t<div class=\"text-content\">\n\t\t<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-medium wp-image-485\" src=\"https:\/\/vetmed.iastate.edu\/vpath\/wp-content\/uploads\/CPC-logo-1-300x139.png\" alt=\"Comparative Pathology Core Services logo\" width=\"300\" height=\"139\" srcset=\"https:\/\/vetmed.iastate.edu\/vpath\/wp-content\/uploads\/CPC-logo-1-300x139.png 300w, https:\/\/vetmed.iastate.edu\/vpath\/wp-content\/uploads\/CPC-logo-1-768x356.png 768w, https:\/\/vetmed.iastate.edu\/vpath\/wp-content\/uploads\/CPC-logo-1.png 868w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<h2>Contact<\/h2>\n<p>Please feel free to contact the facility if you have any question regarding this service or how it could benefit your current or future projects.<\/p>\n<p><strong>Rachel Phillips, <\/strong><em>Assistant Scientist II<\/em><br \/>\n<a href=\"mailto:rlp79@iastate.edu\">rlp79@iastate.edu<\/a>, 515-294-0953<\/p>\n<p><strong>Eric Cassmann<\/strong>, <em>Faculty Contact<\/em><br \/>\n<a href=\"mailto:cassmann@iastate.edu\">cassmann@iastate.edu<\/a>, 515-294-0876<\/p>\n\n\t<\/div>\n<\/div>\n\n\n<div\n\tclass=\"paragraph-widget paragraph-widget--button-set\">\n\t<div class=\"iastate22-button-set\">\n\t\t<ul>\n\t\t\t\t\t\t\t\t\t\t\t\t<li>\n\t\t\t\t\t\t<a class=\"iastate22-button\"\n\t\t\t\t\t\t   href=\"https:\/\/vetmed.iastate.edu\/vpath\/wp-content\/uploads\/CPC-Request-for-Service_2021.pdf\" target=\"_blank\">Request for Service Form\n\t\t\t\t\t\t\t<span class=\"arrow\"><\/span><\/a>\n\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t<\/ul>\n\t<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":370,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-229","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.6 - 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