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Qijing Zhang

Qijing Zhang
Qijing Zhang

BVsc, MS, PhD

Professor and Associate Dean for Research and Graduate Studies
Vet Microbiology & Preventive Medicine
(515) 294-2038
1116 Vet Med
Expertise / Research Area

Food safety; antibiotic resistance; bacterial genetics; pathogen-host interactions; prevention and control of infectious diseases

Teaching

 

VMPM 586: Medical Bacteriology
Objectives: 1) Develop an understanding of pathogenic bacteria that cause infectious diseases in human beings but do not have enough veterinary importance to warrant coverage in VMPM 386; 2) Explore topics currently of high interest in human and veterinary bacteriology; 3) Develop an understanding of and ability to critique current research relevant to the study of pathogenic bacteria; and 4) Design and present an original research proposal
Education

B.V.Sc    Shandong Agricultural University (China)     1983          Vet Medicine
M.S.       National Inst. Veterinary Biologics (China)   1986          Vet Microbiology
Ph.D.     Iowa State University                                   1994          Immunobiology
Postdoc University of Missouri-Columbia                  1994-1997   Molecular Microbiology

Selected Publications

Sahin, Orhan, Collette Fitzgerald, Steven Stroika, Dr. Shaohua Zhao, Rachel Sippy, Patrick Kwan, Paul Plummer, Jing Han, Michael Yaeger, and Qijing Zhang.  2012. Molecular Evidence for Zoonotic Transmission of an Emergent Highly Pathogenic Campylobacter jejuni Clone in the United States. J. Clin. Microbiol. 50(3):680-7.

Plummer, Paul, Orhan Sahin, Eric Burrough, Rachel Sippy, Kathy Mou, Jessica Rabenold, Mike Yaeger, and Qijing Zhang. 2012. The critical role of LuxS in the virulence of Campylobacter jejuni in a guinea pig model of abortion.  Infect. Immun. Infect. Immun. 80(2):585-93.

Luangtongkum, Taradon, Zhangqi Shen, Virginia Seng, Orhan Sahin, Byeonghwa Jeon, Peng Liu, and Qijing Zhang. 2012. Impaired fitness and transmission of macrolide-resistant Campylobacter jejuni in its natural host. Antimicrob. Agents Chemother. 56(3):1300-8.

Muraoka Wayne T. and Qijing Zhang. 2011. Phenotypic and genotypic evidence for L-fucose utilization by Campylobacter jejuni. J. Bacteriol. 193(5):1065-75.

Jeon Byeonghwa and Qijing Zhang. 2009. Sensitization of Campylobacter jejuni to fluoroquinolone and macrolide antibiotics by antisense inhibition of the CmeABC multidrug efflux transporter. J. Antimicrob. Chemother. J. Antimicrob. Chemother. 63:946-948.

Luangtongkum Taradon, Byeonghwa Jeon, Jing Han, Paul Plummer, Catherine M. Logue, and Qijing Zhang. 2009. Antibiotic resistance in Campylobacter: molecular mechanisms and ecology of emergence, transmission and persistence. Future Microbiol. 2:189-200.

Han, Jing, Orhan Sahin, Yi-Wen Barton, and Qijing Zhang. 2008. Key role of Mfd in the development of fluoroquinolone resistance in Campylobacter. PLoS Pathog 4(6): e1000083. doi:10.1371/journal.ppat.1000083.

 

Baoqing Guo, Ying Wang, Feng Shi, Yi-Wen Barton, Paul Plummer, Donald L. Reynolds, Dan Nettleton, Tara Grinnage-Pulley, Jun Lin and Qijing Zhang. 2008. CmeR functions as a pleiotropic regulator and is required for optimal colonization of Campylobacter jejuni in vivo. J. Bact. 190:1879-1890.

 

Jeon Byeonghwa, Wayne Muraoka, Qijing Zhang. 2008. Role of Cj1211 in natural transformation and emergence of antibiotic resistance in Campylobacter jejuni. Antimicrob. Agents Chemother. 52:2699-2708.

 

Orhan Sahin, Paul J. Plummer, Dianna M. Jordan, Kapllan Sulaj, Sonia Pereira, Suelee Robbe-Austerman, Liping Wang, Michael J. Yaeger, Lorraine J. Hoffman, and Qijing Zhang. 2008 Emergence of a tetracycline-resistant Campylobacter jejuni clone associated with ovine abortion in the United States. J. Clin. Microbiol. 46:1663-1671.

 

Gu Rouyu, Chih-Chia Su, Feng Shi, Ming Li, Gerry McDermott, Qijing Zhang and Edward W. Yu. 2007. Crystal Structure of the transcriptional regulator CmeR from Campylobacter jejuni.  J. Mol. Biol. 372:583-593.

 

Lin Jun, Meiguan Yan, Orhan Sahin, Sonia Pereira, Yun-Juan Chang, and Qijing Zhang. 2007. Effect of macrolide usage on the emergence of erythromycin-resistant Campylobacter in chickens. Antimicrob. Agents  Chemother. 51: 1678-1686.

 

Jeon B. and Qijing Zhang. 2007. Cj0011c, a periplasmic single- and double-stranded DNA binding protein, contributes to natural transformation in Campylobacter jejuni. J. Bact. 189:7399-7407.

 

Yan, M., O, Sahin, J. Lin, and Q. Zhang. 2006. Role of the CmeABC efflux pump in the emergence of fluoroquinolone-resistant Campylobacter under selection pressure. J. Antimicrobial. Chemother. 58:1154-1159.

 

Zhang, Q., O. Sahin, P. F. McDermott, and S. Payot. 2006. Fitness of antimicrobial resistant Campylobacter and Salmonella. Microbes Infect.

 

Lin, J., M. Akiba, O. Sahin, and Q. Zhang. 2005. CmeR functions as a transcriptional repressor for the multidrug efflux pump CmeABC in Campylobacter jejuni. Antimicrob. Agents Chemother.  49:1067-1075.

 

Luo N, S. Pereira, O. Sahin, J. Lin, S. Huang, L. Michel, and Q. Zhang. 2005. Enhanced in vivo fitness of fluoroquinolone-resistant Campylobacter jejuni in the absence of antibiotic selection pressure. Proc. Natl. Acad. Sci. U. S. A. 102:541-546.

 

Raphael, B. H., S. Pereira, E. Dave, G. A. Flom, Q. Zhang, J. M. Ketley, and M. E. Konkel. 2005. The Campylobacter jejuni response regulator, CBbrR, modulates sodium deoxycholate resistance and chicken colonization. J. Bact. 187(11):3662-70.

 

Lin, J.,  C.  Cagliero, B. Guo, Y-W., Barton,  M. C. Maurel, S. Payot, and Q. Zhang. 2005. Bile salts modulate the expression of multidrug efflux pump CmeABC in Campylobacter jejuni. J. Bacteriol. 187:7417-7424.

 

Leadership

VMPM Departmental Officer of Graduate Education

Chair, CVM International Development Committee

Chair, Research Advisory Committee

Associate Dean for Research and Graduate Studies
 
Chair, Division Z (Animal Health), American Society for Microbiology

 

Honors & Awards

Endowed Frank K. Ramsey Chair in Veterinary Medicine, Iowa State University, 2003-2012.

Pfizer Award for Research Excellence, Iowa State University, 2007

 

Memberships

American Society for Microbiology

Conference of Research Workers in Animal Diseases

American Association for the Advancement of Science

American Veterinary Medical Association

American Association of Avian Pathologists