Dipak Kumar Sahoo
Research Scientist III
Veterinary Clinical Sciences
dsahoo@iastate.edu
515-294-7311
1469 Patterson 1800 Chris
ISU Directory Link
Web of Science Platform | Clarivate
General
I am a Research Scientist (Associate Graduate Faculty) in Veterinary Clinical Sciences, and my current research focuses on the development of molecular markers and understanding molecular mechanisms linked with inflammatory bowel diseases, colorectal cancer, and sepsis, as well as the impact of antioxidants/oxidative stress in various pathophysiological conditions. I have an extensive research background of over 20 years with doctoral and postdoctoral training in animal biology/zoology, specific training and expertise in working on various disease models, cancer biology, molecular biology, biochemistry, genetics and ex vivo organoid studies with >150 research publications (Google Scholar citations: 3933, h-index: 34; i10-index: 83). As of May/June 2025 (Web of Science), my 3 highly cited publications, in which I am the leading author and/or corresponding author, placed 2 in the top 1% of the academic field of Microbiology and Biology & Biochemistry and 1 in the top 0.1% of the academic field of Clinical Medicine. I have reviewed 224 manuscripts for 72 different peer-reviewed international journals from various publishers, including Nature, Elsevier, Springer, Wiley-Blackwell, Hindawi, Frontiers, MDPI, PLoS, and Karger. I received "Sentinels of Science-September 2016" for serving as a "Top peer reviewer" in the fields of Biochemistry, Genetics, and Molecular Biology, in recognition of my contribution as a reviewer. I also served as a Guest Associate Editor for research topics in Frontiers in Endocrinology (Cellular Endocrinology & Translational and Clinical Endocrinology) and Frontiers in Genetics (Human and Medical Genomics).
Education & Certifications
Postdoctoral Training 2014-2019
Iowa State University, Ames, IA, USA
Postdoctoral Training 2009-2014
University of Kentucky, Lexington, KY, USA
Ph.D. in Zoology 2007
Utkal University, INDIA
Thesis title: “Modulation of rat testicular antioxidant defense system by experimentally induced hypo-and hyperthyroidism”; http://hdl.handle.net/10603/190995
M.Phil. in Zoology 2002
Utkal University, INDIA
M.Sc. in Zoology (Specialization: Biochemistry) 2001
Utkal University, INDIA
B.Sc. (Honours with Distinction) 1998
Utkal University, INDIA
SPECIAL COURSE
Preparing Future Faculty 2018-2019
Iowa State University, Ames, IA
Completed two semesters of a professional development course. The first semester focused on preparation for a faculty position. The second semester focused on developing teaching skills, including designing active learning classroom activities, designing effective assessments, and implementing alternative teaching styles such as Team-Based Learning and various pedagogical strategies.
Transforming Your Research into Teaching (TYRIT) Program 2019
Iowa State University’s Preparing Future Faculty Program. This section ran in tandem with "TYRIT," offered from June 4, 2019, to July 30, 2019, by Dr. Darren Hoffmann, University of Iowa.
Research Focus & Interests
ORCID: https://orcid.org/my-orcid?orcid=0000-0003-3748-3395
Web of Science: https://www.webofscience.com/wos/author/record/876276
NCBI: https://www.ncbi.nlm.nih.gov/myncbi/dipak%20kumar.sahoo.1/bibliography/public/
Honors & Awards
- Recipient of Sentinels of Science: Top peer reviewer in Biochemistry, Genetics and Molecular Biology - 2016 (https://www.webofscience.com/wos/author/record/M-8818-2013). (Sentinels of Science Awards to pay homage to the highest achievers in peer review each year, presented by Web of Science)
- Iowa State University - College of Veterinary Medicine Professional & Scientific Research Award – 2021
- Iowa State University - College of Veterinary Medicine Service Team of the Year Award – 2025 (for VCS Core Lab/team members: Dipak Kumar Sahoo, M.M. Merodio & A.E. Jergens)
- Listed in Stanford/Elsevier - World's Top 2% Scientists – 2025 (https://topresearcherslist.com/Home/Search?AuthFull=Sahoo%2C+Dipak+Kumar)
Leadership/Committees/Council
EDITORIAL DUTIES
Other Scholarly Contributions (as Guest Associate Editor):
- Frontiers in Endocrinology: Cellular Endocrinology
Research Topic: Hormonal Imbalance-Associated Oxidative Stress and Protective Benefits of Nutritional Antioxidants (Completed)
Topic Editors: Sahoo, D.K., Samanta, L., Kesari, K.K. & Mukherjee, S.
- Frontiers in Endocrinology: Translational and Clinical Endocrinology
Research Topic: Gastrointestinal (GI) disorders and antioxidant therapeutics
Topic Editors: Sahoo, D.K., Chainy, G.B.N. & Jergens, A.E.
- Frontiers in Genetics: Human and Medical Genomics
Research Topic: Understanding Molecular Mechanisms to Facilitate the Development of Biomarkers for Therapeutic Intervention in Gastrointestinal Diseases and Sepsis
Research Topic Editors: Sahoo, D.K., Heilmann, R. & Patel, A.
- Review Editor for Frontiers in Toxicology (Environmental Toxicology)
EXPERIENCE IN PEER REVIEW
I have reviewed >200 manuscripts for >60 different internationally reputed peer-reviewed journals from publishers such as Nature, Elsevier, Hindawi, Karger, Springer Nature, Frontiers, Wiley-Blackwell, MDPI, and others.
Referee/Reviewer: (https://www.webofscience.com/wos/author/record/M-8818-2013)
Memberships
- American Gastroenterological Association (AGA) (2023-today)
- American Association for Cancer Research (AACR) (2022)
- Society for In Vitro Biology (2013)
- Indian Society for Comparative Endocrinology (2005-2007)
Selected Publications
For the full list, please see Google Scholar
(2025)
Sahoo, D.K., Wong, D., Paital, B., Ruby, R.E., Patel, A., 2025. Role of Endoplasmic Reticulum Stress-Associated Genes in Septic Neonatal Foals. Antioxidants 2025, Vol. 14, Page 1024 14, 1024. https://doi.org/10.3390/ANTIOX14081024.
Sahoo, D. K., Stewart, T., Lindgreen, E. M., Patel, B., Patel, A., Trivedi, J. N., Parker, V., Rudinsky, A. J., Winston, J. A., Bourgois-Mochel, A., Mochel, J. P., Allenspach, K., Heilmann, R. M., & Jergens, A. E., 2025. Restorative Effects of Synbiotics on Colonic Ultrastructure and Oxidative Stress in Dogs with Chronic Enteropathy. Antioxidants, 14(6), 727. https://doi.org/10.3390/antiox14060727.
Sahoo, D.K., Chainy, G.B.N. and Jergens, A.E., 2025. Editorial: Gastrointestinal (GI) disorders and antioxidant therapeutics. Frontiers in Endocrinology, 16, p.1588417.
Sahoo, D.K., Heilmann, R.M. and Patel, A., 2025. Editorial: Understanding molecular mechanisms to facilitate the development of biomarkers for therapeutic intervention in gastrointestinal diseases and sepsis. Frontiers in Genetics, 16, p.1581299.
Mason, B., Sahoo, D.K., lennarella-Servantez, C.A. et al., 2025. Effects of a western diet on colonic dysbiosis, bile acid dysmetabolism and intestinal inflammation in clinically healthy dogs. J Vet Intern Med. 2025, 39:e70035. https://doi.org/10.1111/jvim.70035.
Wong, D., Sahoo, D.K., Faivre, C., Kopper, J., Dersh, K., Beachler, T., Esser, M., 2025. Oxidative stress in critically ill neonatal foals. J Vet Intern Med. 2025;39:e17297.
Hoerdemann, M., Sahoo, D.K., Allbaugh, R.A., Kubai, M.A., 2025. Ultraviolet C (UV-C) Light Therapy Inhibits Pathogens Associated With Equine Keratomycosis at Different Corneal Depths—An Ex Vivo Study. Vet Ophthalmol 0, 1–15. https://doi.org/10.1111/VOP.70110
Hoerdemann, M., Sahoo, D.K., Allbaugh, R.A. and Kubai, M.A. (2025), Ultraviolet C (UV-C) Light Therapy for Equine Ulcerative Keratomycosis—An In Vitro Study. Vet Ophthalmol. https://doi.org/10.1111/vop.70012.
Treadwell, C., Sahoo, D.K., Bujan, J.D., Allbaugh, R.A., Stinman, C.C., Kubai, M.A., 2025. Antimicrobial Effect of Ultraviolet C (UV‐C) Light Compared to Standard Povidone‐Iodine Protocol for Preoperative Disinfection of the Periocular Area. Vet Ophthalmol. https://doi.org/10.1111/VOP.70065.
Turicea, B., Sahoo, D.K., Allbaugh, R.A., Stinman, C.C., Kubai, M.A., 2025. Antimicrobial Activity of Ultraviolet C Light as a Potential Novel Treatment for Moraxella bovis Infection—An In Vitro Study. Vet Ophthalmol 0, 1–11. https://doi.org/10.1111/VOP.70087.
Zdyrski, C., Gabriel, V., Ospina, O., Nicholson, H., Catucci, M., Melvin, B.J., Wickham, H., Sahoo, D.K., Dao, K., Aguilar Meza, L.S. and Ralston, A. et al., 2025. Establishment and Transcriptomic Characterization of Canine Organoids from Multiple Tissues. Frontiers in Cell and Developmental Biology, 13, p.1680376. https://doi.org/10.3389/fcell.2025.1680376
Garrity, S., Whittemore, J. C., Sahoo, D. K., Morgan, S., Lindgreen, E., VanDeWalle, S., Suchodolski, J. S., & Jergens, A. E. (2025). Effects of High-Dose Prednisone on the Gastrointestinal Microbiota of Healthy Dogs. Veterinary Sciences, 12(3), 216. https://doi.org/10.3390/vetsci12030216.
Corbett, M. P., Gabriel, V., Livania, V., Díaz-Regañón, D., Ralston, A., Zdyrski, C., Liu, D., Minkler, S., Wickham, H., Lincoln, A., Paukner, K., Atherly, T., Merodio, M. M., Sahoo, D. K., Meyerholz, D. K., Allenspach, K., & Mochel, J. P. (2025). A Preclinical Model to Assess Intestinal Barrier Integrity Using Canine Enteroids and Colonoids. Biology, 14(3), 270. https://doi.org/10.3390/biology14030270.
(2024)
Sahoo, D.K., Samanta, L., Kesari, K.K. and Mukherjee, S., 2024. Editorial: Hormonal imbalance-associated oxidative stress and protective benefits of nutritional antioxidants. Frontiers in Endocrinology, 15, p.1368580.
Sahoo, D.K., Wong, D., Patani, A., Paital, B., Yadav, V.K., Patel, A. and Jergens, A.E., 2024. Exploring the role of antioxidants in sepsis-associated oxidative stress: a comprehensive review. Frontiers in Cellular and Infection Microbiology, 14, p.1348713.
Turicea, B., Sahoo, D.K., Allbaugh, R.A., Stinman, C.C., Kubai, M.A., 2024. Novel treatment of infectious keratitis in canine corneas using ultraviolet C (UV-C) light. Veterinary Ophthalmology. 2024;00:1–15. https://doi.org/10.1111/vop.13265.
Gabriel, V., Zdyrski, C., Sahoo, D.K., Ralston, A., Wickham, H., Bourgois-Mochel, A., Ahmed, B., Merodio, M.M., Paukner, K., Piñeyro, P., Kopper, J.,.. and Allenspach, K., 2024. Adult animal stem cell-derived organoids in biomedical research and the one health paradigm. International journal of molecular sciences, 25(2), p.701.
Fietz, S.A., Kalusa, M., Jergens, A.E., Sahoo, D.K., Stewart, T. and Heilmann, R.M., 2024. Ultrastructural changes in chronic inflammatory enteropathies—a comparison between dogs and humans. Frontiers in Cell and Developmental Biology, 12, p.1379714.
Ciou, M. J., Jerram, R., Syrcle, J., Levien, A.S., Sahoo, D.K. and Kraus, K., 2024. Thoracic and Lumbar Spinal Fractures and Luxations in 26 Dogs and 2 Cats—Stabilization by String of Pearls Locking Plates. VCOT Open, 07(02): e108-e113. DOI: 10.1055/s-0044-1789252.
Shah, H., Trivedi, M., Gurjar, T., Sahoo, D. K., Jergens, A. E., Yadav, V. K., Patel, A. and Pandya, P., 2024. Decoding the Gut Microbiome in Companion Animals: Impacts and Innovations. Microorganisms, 12(9), 1831; https://doi.org/10.3390/microorganisms12091831.
Stewart, A.S., Kopper, J.J., McKinney-Aguirre, C., Veerasamy, B., Sahoo, D.K., Freund, J.M. and Gonzalez, L.M., 2024. Assessment of equine intestinal epithelial junctional complexes and barrier permeability using a monolayer culture system. Front. Vet. Sci. 11:1455262. https://doi.org/10.1039/D4RA06117A.
Kothadiya, S., Cutshaw, G., Uthaman, S., Hassan, N., Sahoo, D. K., Wickham, H., Quam, E., Allenspach, K., Mochel, J. P. and Bardhan, R., 2024. Cisplatin-induced metabolic responses measured with Raman spectroscopy in cancer cells, spheroids, and canine-derived organoids. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.4c08629.
Zdyrski, C., Gabriel, V., Gessler, T.B., Ralston, A., Sifuentes-Romero, I., Kundu, D., Honold, S., Wickham, H., Topping, N.E., Sahoo, D.K., Bista, B., ….& Valenzuela, N., 2024. Establishment and characterization of turtle liver organoids provides a potential model to decode their unique adaptations. Communications biology, 7(1), p.218.
(2023)
Sahoo, D.K., Heilmann, R.M., Paital, B., Patel, A., Yadav, V.K., Wong, D. and Jergens, A.E., 2023. Oxidative stress, hormones, and effects of natural antioxidants on intestinal inflammation in inflammatory bowel disease. Frontiers in Endocrinology, 14, p.1217165.
Sahoo, D.K., Martinez, M.N., Dao, K., Gabriel, V., Zdyrski, C., Jergens, A.E., Atherly, T., Iennarella-Servantez, C.A., Burns, L.E., Schrunk, D. and Volpe, D.A., 2023. Canine intestinal organoids as a novel in vitro model of intestinal drug permeability: A proof-of-concept study. Cells, 12(9), p.1269.
Sahoo DK, Allenspach K, Mochel JP, Parker V, Rudinsky AJ, Winston JA, Bourgois-Mochel A, Ackermann M, Heilmann RM, Köller G, Yuan L, Stewart T, Morgan S, Scheunemann KR, Iennarella-Servantez CA, Gabriel V, Zdyrski C, Pilla R, Suchodolski JS, Jergens AE. Synbiotic-IgY Therapy Modulates the Mucosal Microbiome and Inflammatory Indices in Dogs with Chronic Inflammatory Enteropathy: A Randomized, Double-Blind, Placebo-Controlled Study. Veterinary Sciences. 2023; 10(1):25. https://doi.org/10.3390/vetsci10010025
Sahoo, D.K., Borcherding, D.C., Chandra, L., Jergens, A.E., Atherly, T., Bourgois-Mochel, A., Ellinwood, N.M., Snella, E., Severin, A.J., Martin, M. and Allenspach, K., 2022. Differential transcriptomic profiles following stimulation with lipopolysaccharide in intestinal organoids from dogs with inflammatory bowel disease and intestinal mast cell tumor. Cancers, 14(14), p.3525.
Díaz-Regañón, D., Gabriel, V., Livania, V., Liu, D., Ahmed, B.H., Lincoln, A., Wickham, H., Ralston, A., Merodio, M.M., Sahoo, D.K. and Zdyrski, C., et al., 2023. Changes of enterocyte morphology and enterocyte: goblet cell ratios in dogs with protein-losing and non-protein-losing chronic enteropathies. Veterinary sciences, 10(7), p.417.
Moshksayan, K., Harihara, A., Mondal, S., Hegarty, E., Atherly, T., Sahoo, D.K., Jergens, A.E., Mochel, J.P., Allenspach, K., Zoldan, J. and Ben-Yakar, A., 2023. OrganoidChip facilitates hydrogel-free immobilization for fast and blur-free imaging of organoids. Scientific Reports, 13(1), p.11268.
(2022)
Bedos L, Wickham H, Gabriel V, Zdyrski C, Allbaugh RA, Sahoo DK, Sebbag L, Mochel JP and Allenspach K (2022) Culture and characterization of canine and feline corneal epithelial organoids: A new tool for the study and treatment of corneal diseases. Front. Vet. Sci. 9:1050467. doi: 10.3389/fvets.2022.1050467.
Allenspach, K., Borcherding, D.C., Iennarella-Servantez, C.A., Mosichuk, A.P., Atherly, T., Sahoo, D.K., Kathrani, A., Suchodolski, J.S., Bourgois-Mochel, A., Serao, M.R. and Serao, N.V., 2022. Ketogenic diets in healthy dogs induce gut and serum metabolome changes suggestive of anti-tumourigenic effects: A model for human ketotherapy trials. Clinical and translational medicine, 12(9), pp.e1047-e1047.
Gabriel, V., Zdyrski, C., Sahoo, D. K., Dao, K., Bourgois-Mochel, A., Atherly, T., Martinez, M. N., Volpe, D. A., Kopper, J., Allenspach, K., Mochel, J. P. Canine Intestinal Organoids in a Dual-Chamber Permeable Support System. J. Vis. Exp. (181), e63612, doi:10.3791/63612 (2022).
Gabriel, V., Zdyrski, C., Sahoo, D. K., Dao, K., Bourgois-Mochel, A., Kopper, J., Zeng, X. L., Estes, M. K., Mochel, J. P., Allenspach, K. Standardization and Maintenance of 3D Canine Hepatic and Intestinal Organoid Cultures for Use in Biomedical Research. J. Vis. Exp. (179), e63515, doi:10.3791/63515 (2022).
(2021)
Kopper J, Iennarella-Servantez C, Jergens AE, Sahoo DK, Guillot E, Bourgois Mochel A, Martinez M, Allenspach K, Mochel JP. Harnessing the Biology of Canine Intestinal Organoids to Heighten Understanding of Inflammatory Bowel Disease Pathogenesis and Accelerate Drug Discovery: A One Health Approach. Frontiers in Toxicology.:47 (2021).
Shanahan M, Kanke M, Oyesola OO, Hung YH, Koch-Laskowski K, Singh AP, Peck BC, Biraud M, Sheahan B, Cortes JE, Gong H, Sahoo DK, Cubitt R, Kurpios NA, Mochel JP, Allenspach K, McElroy SJ, Ding S, von Moltke J, Dekaney CM, Tait-Wojno ED, Sethupathy P. Multi-omic analysis defines the first microRNA atlas across all small intestinal epithelial lineages and reveals novel markers of almost all major cell types. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2021 Oct 13.
Minkler S, Lucien F, Kimber MJ, Sahoo DK, Bourgois-Mochel A, Musser M, Johannes C, Frank I, Cheville J, Allenspach K, Mochel JP. Emerging Roles of Urine-Derived Components for the Management of Bladder Cancer: One Man’s Trash is Another Man’s Treasure. Cancers. 2021 Jan;13(3):422.
(2020)
Chainy GB, Sahoo DK. Hormones and oxidative stress: an overview. Free radical research. 2020 Jan 2;54(1):1-26.
(2018)
Yoon JS, Sahoo DK, Maiti IB, Palli SR. Identification of target genes for RNAi-mediated control of the Twospotted Spider Mite. Scientific reports. 2018 Oct 2;8(1):1-7.
(2015)
Sarkar S, Jain S, Rai V, Sahoo DK, Raha S, Suklabaidya S, Senapati S, Rangnekar VM, Maiti IB, Dey N. Plant-derived SAC domain of PAR-4 (Prostate Apoptosis Response 4) exhibits growth inhibitory effects in prostate cancer cells. Frontiers in Plant Science. 2015 Oct 7;6:822.
(2012)
Sahoo DK, Roy A. Compromised rat testicular antioxidant defence system by hypothyroidism before puberty. International Journal of Endocrinology. 2012 Jan 1;2012.
(2010)
Chattopadhyay S, Sahoo DK, Roy A, Samanta L, Chainy GB. Thiol redox status critically influences mitochondrial response to thyroid hormone‐induced hepatic oxidative injury: A temporal analysis. Cell Biochemistry and Function: Cellular biochemistry and its modulation by active agents or disease. 2010 Mar;28(2):126-34.
(2008)
Sahoo DK, Roy A, Chainy GB. Protective effects of vitamin E and curcumin on L-thyroxine-induced rat testicular oxidative stress. Chemico-biological interactions. 2008 Nov 25;176(2-3):121-8.
Sahoo DK, Roy A, Bhanja S, Chainy GB. Hypothyroidism impairs antioxidant defence system and testicular physiology during development and maturation. General and Comparative Endocrinology. 2008 Mar 1;156(1):63-70.
Sahoo D, Roy A, Chainy G. Rat testicular mitochondrial antioxidant defence system and its modulation by aging. Acta Biologica Hungarica. 2008 Dec 1;59(4):413-24.
(2007)
Chattopadhyay S, Sahoo DK, Subudhi U, Chainy GB. Differential expression profiles of antioxidant enzymes and glutathione redox status in hyperthyroid rats: a temporal analysis. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2007 Sep 1;146(3):383-91.