Joaquin Caceres

BS, PhD

Assistant Professor
Vet Microbiology & Preventive Medicine
jcaceres@iastate.edu
515-294-4837
Patterson
ISU Directory Link

General

Lab website: https://cacerescj.research.cvm.iastate.edu

Pubmed bibliography: https://www.ncbi.nlm.nih.gov/myncbi/1z5gNVouvse5s/bibliography/public/

Education & Certifications

PhD in Microbiology (2017). Universidad de Chile. Santiago, Chile

BSc in Biochemistry and Molecular Biology (2013). Pontificia Universidad Catolica de Chile. Santiago, Chile.

Research Focus & Interests

The Caceres lab is interested in investigating molecular factors modulating the pathogenesis and viral-host interactions of influenza and coronaviruses affecting humans and animals. To achieve this, we employ a combination of classical molecular virology techniques, reverse genetics, OMICS approaches, and various in vitro and in vivo models. Our research can contribute to developing novel diagnostic tools, antivirals (viral or host-targeted), and vaccines against various viral agents.

Memberships

American Society for Virology (2021-present)

Selected Publications

1: Tosheva II, Filaire F, Rijnink WF, de Meulder D, van Kekem B, Bestebroer TM, Funk M, Spronken MI, Cáceres CJ, Perez DR, Richard M, Koopmans MPG, Fraaij PLA, Fouchier RAM, Herfst S. Influenza A(H5N1) shedding in air corresponds to transmissibility in mammals. Nat Microbiol. 2024 Dec 2. doi: 10.1038/s41564-024-01885-6. Epub ahead of print. PMID: 39623068.

2: Caceres CJ, Gay LC, Faccin FC, Regmi D, Palomares R, Perez DR. Influenza A(H5N1) Virus Resilience in Milk after Thermal Inactivation. Emerg Infect Dis. 2024 Nov;30(11):2426-2429. doi: 10.3201/eid3011.240772. Epub 2024 Oct 3. PMID: 39361770; PMCID: PMC11521188.

3: Caceres CJ, Gay LC, Faccin FC, Pérez DR. Use of Reverse Genetics for the Generation of Recombinant Influenza Viruses Carrying Nanoluciferase. Methods Mol Biol. 2024;2733:47-74. doi: 10.1007/978-1-0716-3533-9_4. PMID: 38064026.

4: Seibert B, Cáceres CJ, Carnaccini S, Cardenas-Garcia S, Gay LC, Ortiz L,Geiger G, Rajao DS, Ottesen E, Perez DR. Pathobiology and dysbiosis of the respiratory and intestinal microbiota in 14 months old Golden Syrian hamsters Infected with SARS-CoV-2. PLoS Pathog. 2022 Oct 24;18(10):e1010734. doi: 10.1371/journal.ppat.1010734. PMID: 36279276; PMCID: PMC9632924.

5: Cáceres CJ, Hu Y, Cárdenas-García S, Wu X, Tan H, Carnaccini S, Gay LC, Geiger G, Ma C, Zhang QY, Rajao D, Perez DR, Wang J. Rational design of a deuterium-containing M2-S31N channel blocker UAWJ280 with In vivo antiviral efficacy against both oseltamivir sensitive and -resistant influenza A viruses. Emerg Microbes Infect. 2021 Dec;10(1):1832-1848. doi: 10.1080/22221751.2021.1972769. PMID: 34427541; PMCID: PMC8451667.

6: Cáceres CJ, Cardenas-Garcia S, Jain A, Gay LC, Carnaccini S, Seibert B, Ferreri LM, Geiger G, Jasinskas A, Nakajima R, Rajao DS, Isakova-Sivak I, Rudenko L, Vincent AL, Davies DH, Perez DR. Development of a Novel Live Attenuated Influenza A Virus Vaccine Encoding the IgA-Inducing Protein. Vaccines (Basel). 2021 Jun 27;9(7):703. doi: 10.3390/vaccines9070703. PMID: 34198994; PMCID: PMC8310050.

7: Cáceres CJ, Cardenas-Garcia S, Carnaccini S, Seibert B, Rajao DS, Wang J, Perez DR. Efficacy of GC-376 against SARS-CoV-2 virus infection in the K18 hACE2 transgenic mouse model. Sci Rep. 2021 May 5;11(1):9609. doi: 10.1038/s41598-021-89013-w. PMID: 33953295; PMCID: PMC8100161.

8: Cáceres CJ, Angulo J, Lowy F, Contreras N, Walters B, Olivares E, Allouche D, Merviel A, Pino K, Sargueil B, Thompson SR, López-Lastra M. Non-canonical translation initiation of the spliced mRNA encoding the human T-cell leukemia virus type 1 basic leucine zipper protein. Nucleic Acids Res. 2018 Nov 16;46(20):11030-11047. doi: 10.1093/nar/gky802. Erratum in: Nucleic Acids Res. 2019 Feb 20;47(3):1599. doi: 10.1093/nar/gky1249. PMID: 30215750; PMCID: PMC6237760.