Jonathan Paul M Mochel
DVM, MSc, PhD, Diplomate ECVPT
Associate Professor
515-294-7424
2448 Lloyd
Dr. Jon Mochel obtained his Veterinary Medical Degree from the National Veterinary School of Alfort. He completed his Doctorate studying Neurosciences in collaboration with the College de France and received the Silver Medal from Paris XII for his work. Dr. Mochel holds a MS in Pharmacology and Pharmacokinetics and is a Diplomate of the European College of Veterinary Pharmacology and Toxicology (ECVPT). He completed his Ph.D at Leiden University, with a focus on the mathematical modeling of the renin-angiotensin system for cardiovascular diseases. He is a founder of the Animal Health Modeling & Simulation Society which aims at promoting the dissemination of mathematical modeling in Veterinary Sciences. Dr. Mochel is an Associate Professor in the Department of Biomedical Sciences at Iowa State University and the Chair of the Education and Residency Committee of the ECVPT. He is a Fellow of the American Academy of Veterinary Pharmacology and Therapeutics and an ad hoc Study Section Reviewer for the US National Science Foundation, the UK Medical Research Council and the CNRS/INSERM ATIP-Avenir Program. He is currently the Vice-President of the European Association of Veterinary Pharmacology and Toxicology. His research pertains to the analysis of clinical data obtained from spontaneous animal models of human diseases to bridge the knowledge gap between experimental models and patients. He has authored more than 85 peer-reviewed publications in select biomedical journals and is the co-founder of LifEngine Animal Health, a Y Combinator company developing gene editing solutions for canine oncology, and 3D Health Solutions, a platform for efficient drug screening in pharmaceutical research.
Education & Certifications
- DEFV, Veterinary Medicine Degree, 2006, National Veterinary School of Toulouse, Toulouse (France)
- MS, Pharmacology, 2006, Paul Sabatier University, Toulouse (France)
- DVM, Veterinary Medicine, 2007, Alfort Veterinary School, Paris 12 Val de Marne University, Maisons-Alfort
- MS, Clinical Pharmacology and Pharmacokinetics, 2009, Paul Sabatier University, Toulouse (France)
- Resident, Veterinary Pharmacology and Toxicology (DECVPT), 2013, European College of Veterinary Pharmacology and Toxicology, Basel
- PhD, Quantitative Systems Pharmacology, 2015, Leiden University, Leiden (Netherlands)
Teaching
- Drug Metabolism
- Pharmacokinetics
- Basic Autonomic Anatomy and Physiology and Chemical Mediators
- Cholinergic Transmission
- Noradrenergic Transmission
- 5-HT and Pharmacology of Migraines and Purines
- Local Hormones: Cytokines, Biologically Active Lipids and Peptides
- Peptides and Nitric Oxide
- Control of Blood Glucose and Diabetes Mellitus
- Obesity
- Pituitary and Adrenal Cortex
Professional Positions
- 2016-Present: Associate Professor (Presidential High-Impact), Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA
- 2015-2016: Quantitative Systems Pharmacology Leader, Roche Innovation Center, Pharma Research and Early Development, Basel
- 2013-2015: Senior Pharmacology Modeler, Department of Modeling and Simulation, Novartis, Basel
- 2011-2013: Resident in Veterinary Pharmacology and Toxicology, Novartis, St Johann Campus, Pharmacology Modeling and Simulation, Basel
- 2009-2013: Resident in Veterinary Pharmacology and Toxicology, Novartis, Centre de Recherche Sante Animale, DMPK and Safety, Saint-Aubin
- 2007-2008: Chief Intern, Veterinary Internal Medicine and Surgery, Small Animal Internal Medicine and Surgery, Alfort Veterinary School, Maisons-Alfort
- 2004-2006: Teaching Assistant, Department of Physiology and Therapeutics, National Veterinary School of Toulouse, Toulouse
Research Focus & Interests
- Clinical Pharmacology
- Pharmacokinetics and Pharmacodynamic Modeling
- Cardiovascular Research
- Translational Medicine (One Health)
Honors & Awards
- 2006 - Valedictorian, Veterinary Medicine Graduate Class, National Veterinary School of Toulouse
- 2007 - Silver Medal for Outstanding Veterinary Thesis, Alfort Veterinary School
- 2007 - Valedictorian, Veterinary Internal Medicine and Surgery Internship National Competitive Exam, French National Veterinary Schools
- 2008 - Valedictorian, Master of Sciences (M2), Paul Sabatier University
- 2013 - Diplomate, European College of Veterinary Pharmacology and Toxicology
- 2017 - Chair of the Education and Residency Committee, European College of Veterinary Pharmacology and Toxicology
- 2017 - Fellow, American Academy of Veterinary Pharmacology and Therapeutics
- 2017 - Councilor, American Academy of Veterinary Pharmacology and Therapeutics
- 2017 - President, Animal Health Modeling and Simulation Society
- 2018 - President Elect, European Association of Veterinary Pharmacology and Therapeutics
- 2018 - Alumni, Y Combinator Seed Accelerator Program
- 2019 - Valedictorian, Master of Sciences (M2), Paul Sabatier University (Toulouse)
- 2019 - Iowa State CVM Award for Early Career Achievement in Research
- 2020 - John Pappajohn Entrepreneurial Venture Competition Award (ranked #1/43)
- 2020 - Iowa State Exemplary Faculty Mentor Award
- 2020 - Iowa State University CVM International Service Award
- 2021 - IowaBio Biotechnology Association Award
Leadership/Committees/Council
- 2015 – Committee Chair, European College of Veterinary Pharmacology and Toxicology
- 2017 – President, Animal Health Modeling and Simulation Society
- 2017 – Fellow, American Academy of Veterinary Pharmacology and Therapeutics
- 2017 – Executive Board Member, American Academy of Veterinary Pharmacology and Therapeutics
- 2017 – Executive Board Member, European Federation for Pharmaceutical Sciences
- 2018 – President Elect, European Association of Veterinary Pharmacology and Toxicology
- 2018 – Committee Chair, European College of Veterinary Pharmacology and Toxicology
- 2018 – Thrust Leader, National Institute of Antimicrobial Resistance and Education
- 2019 – Board Member, Translational Renin-Angiotensin-Aldosterone System Interest Group
Memberships
- 2015 – Committee Chair, European College of Veterinary Pharmacology and Toxicology
- 2017 – President, Animal Health Modeling and Simulation Society
- 2017 – Fellow, American Academy of Veterinary Pharmacology and Therapeutics
- 2017 – Executive Board Member, American Academy of Veterinary Pharmacology and Therapeutics
- 2017 – Executive Board Member, European Federation for Pharmaceutical Sciences
- 2017 – Member, International Society of Pharmacometrics
- 2017 – Member, American Association of Pharmaceutical Scientists
- 2017 – Member, American Gastroenterology Association
- 2017 – Member, Comparative Gastroenterology Society
- 2018 – President Elect, European Association of Veterinary Pharmacology and Toxicology
- 2018 – Committee Chair, European College of Veterinary Pharmacology and Toxicology
- 2018 – Thrust Leader, National Institute of Antimicrobial Resistance and Education
- 2018 – Member, Clinical and Laboratory Standards Institute for Antimicrobial Susceptibility Testing
- 2019 – Board Member, Translational Renin-Angiotensin-Aldosterone System Interest Group
- 2021 – Platinum Member, American Association for the Advancement of Science
Selected Publications
1: Sebbag L, Mochel JP. An eye on the dog as the scientist's best friend for translational research in ophthalmology: Focus on the ocular surface. Med Res Rev. 2020 Jul 31. doi: 10.1002/med.21716. Epub ahead of print. PMID: 32735080.
2: Ambrosini YM, Park Y, Jergens AE, Shin W, Min S, Atherly T, Borcherding DC, Jang J, Allenspach K, Mochel JP, Kim HJ. Recapitulation of the accessible interface of biopsy-derived canine intestinal organoids to study epithelial-luminal interactions. PLoS One. 2020 Apr 17;15(4):e0231423. doi:10.1371/journal.pone.0231423. PMID: 32302323; PMCID: PMC7164685.
3: Sebbag L, Moody LM, Mochel JP. Albumin Levels in Tear Film Modulate the Bioavailability of Medically-Relevant Topical Drugs. Front Pharmacol. 2020 Jan 28;10:1560. doi: 10.3389/fphar.2019.01560. PMID: 32047429; PMCID: PMC6997149.
4: Ambrosini YM, Borcherding D, Kanthasamy A, Kim HJ, Willette AA, Jergens A, Allenspach K, Mochel JP. The Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review. Front Aging Neurosci. 2019 Jun18;11:130. doi: 10.3389/fnagi.2019.00130. PMID: 31275138; PMCID: PMC6591269.
5: Schneider BK, Boyer A, Ciccolini J, Barlesi F, Wang K, Benzekry S, Mochel JP. Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non-Small
Cell Lung Cancer. CPT Pharmacometrics Syst Pharmacol. 2019 Aug;8(8):577-586. doi: 10.1002/psp4.12415. Epub 2019 May 9. PMID: 31004380; PMCID: PMC6709425.
6: Chandra L, Borcherding DC, Kingsbury D, Atherly T, Ambrosini YM, Bourgois- Mochel A, Yuan W, Kimber M, Qi Y, Wang Q, Wannemuehler M, Ellinwood NM, Snella
E, Martin M, Skala M, Meyerholz D, Estes M, Fernandez-Zapico ME, Jergens AE, Mochel JP, Allenspach K. Derivation of adult canine intestinal organoids for translational research in gastroenterology. BMC Biol. 2019 Apr 11;17(1):33. doi: 10.1186/s12915-019-0652-6. PMID: 30975131; PMCID: PMC6460554.
7: Sebbag L, Kirner NS, Allbaugh RA, Reis A, Mochel JP. Kinetics of Fluorescein in Tear Film After Eye Drop Instillation in Beagle Dogs: Does Size Really Matter? Front Vet Sci. 2019 Dec 19;6:457. doi: 10.3389/fvets.2019.00457. PMID: 31921915; PMCID: PMC6930880.
8: Klinedinst BS, Pappas C, Le S, Yu S, Wang Q, Wang L, Allenspach-Jorn K, Mochel JP, Willette AA. Aging-related changes in fluid intelligence, muscle and adipose mass, and sex-specific immunologic mediation: A longitudinal UK Biobank study. Brain Behav Immun. 2019 Nov;82:396-405. doi: 10.1016/j.bbi.2019.09.008. Epub 2019 Sep 9. PMID: 31513875.
9: Mochel JP, Ekker SC, Johannes CM, Jergens AE, Allenspach K, Bourgois-Mochel A, Knouse M, Benzekry S, Wierson W, LeBlanc AK, Kenderian SS. CAR T Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds Against Hematological Malignancies. AAPS J. 2019 Apr 8;21(3):50. doi: 10.1208/s12248-019-0322-1. PMID: 30963322.
10: Mochel JP, Teng CH, Peyrou M, Giraudel J, Danhof M, Rigel DF. Sacubitril/valsartan (LCZ696) significantly reduces aldosterone and increases cGMP circulating levels in a canine model of RAAS activation. Eur J Pharm Sci. 2019 Feb 1;128:103-111. doi: 10.1016/j.ejps.2018.11.037. Epub 2018 Nov 30. PMID: 30508581.
Conference Abstracts 2021
Mochel JP. Reverse Translational Pharmacology: Paradigm Shift or Flash in the Pan. European Federation for Pharmaceutical Sciences (Virtual).
Schneider BK, Ward J, Sotillo S, Johnson C, Guillot E, Mochel JP. A Quantitative Systems Pharmacology Model for Bedside Optimization of ACE Inhibitor Dose Scheduling in Veterinary Cardiology. Population Approach Group in Europe Meeting (PAGE) (Virtual).
Zdyrski C, Iennarella-Servantez CA, Sahoo D, Ward J, Long EK, Gabriel V, Minkler SJ, Mao S, Bourgois-Mochel A, Jergens AE, Allenspach K, Mochel JP. Homology Directed Repair in Canine Duodenal Enteroids to Mimic the Wild-Type P-Glycoprotein Mutation. Digestive Disease Week (Virtual).
Mochel JP, Ward JL. RAAS Modulation in Veterinary Cardiology: Which is Stronger – The Light Side or Dark Side of the Force? European College of Veterinary Internal Medicine Annual Conference (Virtual).
Vojtech G, Mochel JP, Zdyrski C, Sahoo D, (…), Jergens AE, Allenspach K. First Description and Preliminary Characterization of a Microfluidic Canine Liver-on-a-Chip. European College of Veterinary Internal Medicine Annual Conference (Virtual).
Ward JL, Guillot E, Domenig O, Ware W, Yuan L, Mochel JP. Renin-Angiotensin Aldosterone System Activity in Cats with Systemic Hypertension or Cardiomyopathy. European College of Veterinary Internal Medicine Annual Conference (Virtual).
Ward JL, Mochel JP. Effects of Cardiovascular Disease and Its Pharmacotherapy on the RAAS in Cats. American College of Veterinary Internal Medicine Forum (Virtual).
Iennarella-Servantez CA, Bedos L, Sahoo DK, Long EK, Petrovsky B, Stokes R, Zdyrski C, Gabriel V, Resop MJ, Rund LR, Mao S, Bourgois-Mochel A, Jergens AE, Mochel JP and Allenspach K. Effects of Macronutrient Composition on Adipose Tissue Deposition and Body Weight in Healthy Dogs Fed Westernized Diet. American College of Veterinary Internal Medicine Forum (Virtual).
Iennarella-Servantez CA, Servantez JM, Yaeger MJ, Ellinwood NM, Rossoni Serao MC, Mochel JP and Allenspach K. Evaluation of Intestinal and System Health Effects of Dogs Fed Extruded versus Raw Meat-Based Diets. American Academy of Veterinary Nutrition (Virtual).
Iennarella-Servantez CA, Kathrani A, Sahoo DK, Long EK, Zdyrski C, Gabriel V, Bedos L, Mao S, Bourgois-Mochel A, Resop MJ, Rund LR, Rossoni Serao M, Jergens AE, Mochel JP and Allenspach K. Colonic Epithelium Develops Proliferative Phenotype in Response to High-Fat, High-Carbohydrate Westernized Diet in Dogs. American Academy of Veterinary Nutrition (Virtual).
Iennarella-Servantez CA, Kathrani A, Sahoo DK, Long EK, Zdyrski C, Gabriel V, Bedos L, Mao S, Bourgois-Mochel A, Resop MJ, Rund LR, Rossoni Serao M, Jergens AE, Mochel JP and Allenspach K. Diet-Induced Clinical Responsiveness of Translational Dog Model for Human Western Diet (WD)-Related Disease Research. American Society of Animal Science (Virtual).
Allenspach K, Phillips GJ, Jergens AE, Mochel JP. Short-Term High-Fat/Low-Carbohydrate Diet in Dogs Induces Dysbiosis of the Gut Microbiota Analogous to Obesity in People. Society of Mucosal Immunology (Virtual).
Gabriel V, Zdyrski C, Dao K, (…), Mochel JP, Allenspach K. Preliminary Characterization of Canine Hepatic Spheroids: A Potential Model For Translational Research in Gastroenterology. International Society for Stem Cell Research (Virtual).
Bedos L, Gabriel V, Zdyrski C, Sahoo DK, Mochel JP and Allenspach K. Isolation of Canine and Feline Corneal Organoids: A New Tool for the Study and Treatment of Corneal Diseases. European College of Veterinary Ophthalmologists (Virtual).
Smith JS, Ebner LS, Cremerius H, Cantrell C, (…), Mochel JP, Kreuder A. A Field Comparison of Two Point of Care Glucometers in Healthy Calves. International Veterinary Emergency and Critical Care Symposium (Virtual).
Publications Full-Texts: Link