Jonathan Paul M Mochel

DVM, MSc, PhD, Diplomate ECVPT

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Dr. Mochel obtained his Veterinary Medical Degree from the National Veterinary School of Toulouse. In 2007, he completed his Doctorate studying Neurosciences in collaboration with the College de France (Paris), and received the Silver Medal from the National Veterinary School of Alfort for his work.

During his veterinary undergraduate studies Dr. Mochel also obtained a Masters in Pharmacology and Pharmacokinetics (2006) from the University of Toulouse. Following a Medical Internship in Veterinary Medicine and Surgery at Maisons-Alfort (2006-2008), he also got a Master of Science (MS) in Pharmacology and Pharmacokinetics from the University of Toulouse. He then pursued a 4-year Specialization program in Pharmacology and Toxicology (European Board) and earned his title of European Specialist in Veterinary Pharmacology and Toxicology.

Dr. Mochel did his Ph.D at Leiden University under the supervision of Pr. Meindert Danhof, whose focus was on the modeling of the dynamics of the renin-angiotensin aldosterone system (RAAS) in dogs.

In 2012, he co-founded the Animal Health Modeling & Simulation (AHM&S) Society, together with Pr. Johan Gabrielsson (University of Agricultural Sciences, Uppsala, Sweden), and Pr. Jim Riviere (Kansas State University, USA), which aims at promoting the development, application, and dissemination of Modeling and Simulation techniques in the field of Veterinary Sciences (http://www.ahmss.com/).


Since joining Novartis Pharmaceuticals in 2013, he had been working as a Senior Pharmacology Modeler in the Modeling and Simulation (M&S) group formed by Dr. Donald Stanski. He thereafter operated as a Quantitative Pharmacology Leader in the Research M&S department of Dr. Thierry Lave at Roche.

Dr. Mochel is currently an Associate Professor in the Department of Biomedical Sciences at Iowa State University and the Chair of the Education and Residency Committee of the European College of Pharmacology and Toxicology (http://www.ecvpt.org/).

His research, which falls under the scope of the One Health initiative, pertains to the analysis of clinical data obtained from spontaneous animal models of human diseases to bridge the knowledge gap between experimental (i.e rodent) models and patients.

Education & Certifications  
  • DEFV, Veterinary Medicine Degree, 2006, National Veterinary School of Toulouse, Toulouse
  • MS, Pharmacology, 2006, Paul Sabatier University, Toulouse
  • DVM, Veterinary Medicine, 2007, Alfort Veterinary School, Paris 12 Val de Marne University, Maisons-Alfort
  • MS, Pharmacology/Pharmacokinetics, 2009, Paul Sabatier University, Toulouse
  • Resident, Veterinary Pharmacology and Toxicology, 2013, European College of Veterinary Pharmacology and Toxicology, Basel​
  • PhD, Pharmacology, 2015, Leiden University, Leiden
Teaching  
  • Drug Metabolism
  • Pharmacokinetics
  • Basic Autonomic Anatomy and Physiology and Chemical Mediators
  • Cholinergic Transmission
  • Noradrenergic Transmission
  • 5-HT and Pharmacology of Migraines and Purines
  • Local Hormones: Cytokines, Biologically Active Lipids and Peptides
  • Peptides and Nitric Oxide
  • Control of Blood Glucose and Diabetes Mellitus
  • Obesity
  • Pituitary and Adrenal Cortex

Professional Positions

  • 2016-Present: Associate Professor (Presidential High-Impact), Department of Biomedical Sciences, Iowa State University College of Veterinary Medicine, Ames, IA
  • 2015-2016: Quantitative Systems Pharmacology Leader, Roche Innovation Center, Pharma Research and Early Development, Basel
  • 2013-2015: Senior Pharmacology Modeler, Department of Modeling and Simulation, Novartis, Basel
  • 2011-2013: Resident in Veterinary Pharmacology and Toxicology, Novartis, St Johann Campus, Pharmacology Modeling and Simulation, Basel
  • 2009-2013: Resident in Veterinary Pharmacology and Toxicology, Novartis, Centre de Recherche Sante Animale, DMPK and Safety, Saint-Aubin
  • 2007-2008: Chief Intern, Veterinary Internal Medicine and Surgery, Small Animal Internal Medicine and Surgery, Alfort Veterinary School, Maisons-Alfort
  • 2004-2006: Teaching Assistant, Department of Physiology and Therapeutics, National Veterinary School of Toulouse, Toulouse
Research Focus & Interests  
  • Clinical Pharmacology
  • Pharmacokinetics and Pharmacodynamic Modeling
  • Cardiovascular Research
  • Translational Medicine (One Health)
Honors & Awards  
  • 2006 - Valedictorian, Veterinary Medicine Graduate Class, National Veterinary School of Toulouse
  • 2007 - Silver Medal for Outstanding Veterinary Thesis, Alfort Veterinary School
  • 2007 - Valedictorian, Veterinary Internal Medicine and Surgery Internship National Competitive Exam, French National Veterinary Schools
  • 2008 - Valedictorian, Master of Sciences (M2), Paul Sabatier University
  • 2013 - Diplomate, European College of Veterinary Pharmacology and Toxicology
  • 2015 - Chair of the Education and Residency Committee, European College of Veterinary Pharmacology and Toxicology
  • 2017 - Scientific Committee of the European Association of Veterinary Pharmacology and Toxicology Triennial, Poland
  • 2019 - ISU CVM Early Career Achievement in Research Award
  • 2020 - ISU Exemplary Faculty Mentor Award
  • 2020 - ISU International Service Award
Memberships  
  • 2011 - Co-Founder, Animal Health Modeling and Simulation Society
  • 2013 - Diplomate, European Coll. of Veterinary Pharmacology and Toxicology
  • 2015 - Member, European Ass. for Veterinary Pharmacology and Toxicology
  • 2015 -Board member, European Federation for Pharmaceutical Sciences
  • 2015 - Chair of the Education and Residency Committee, European College of Veterinary Pharmacology and Toxicology
  • 2016 - Fellow, American Academy of Vet. Pharmacology and Therapeutics
  • 2017 - Counselor, American Academy of Vet. Pharmacology and Therapeutics
  • 2017 - President, Animal Health Modeling and Simulation Society
  • 2017 - Member, International Society of Pharmacometrics
  • 2017 - Member, American Association of Pharmaceutical Scientists
  • 2017 - Member, American Gastroenterology Association
  • 2017 - Member, Comparative Gastroenterology Society
  • 2017 - NIH Study Section, Early Career Reviewer (ECR) Program
Selected Publications  
1: Sebbag L, Mochel JP. An eye on the dog as the scientist's best friend for translational research in ophthalmology: Focus on the ocular surface. Med Res Rev. 2020 Jul 31. doi: 10.1002/med.21716. Epub ahead of print. PMID: 32735080.
2: Ambrosini YM, Park Y, Jergens AE, Shin W, Min S, Atherly T, Borcherding DC, Jang J, Allenspach K, Mochel JP, Kim HJ. Recapitulation of the accessible interface of biopsy-derived canine intestinal organoids to study epithelial-luminal interactions. PLoS One. 2020 Apr 17;15(4):e0231423. doi:10.1371/journal.pone.0231423. PMID: 32302323; PMCID: PMC7164685.
3: Sebbag L, Moody LM, Mochel JP. Albumin Levels in Tear Film Modulate the Bioavailability of Medically-Relevant Topical Drugs. Front Pharmacol. 2020 Jan 28;10:1560. doi: 10.3389/fphar.2019.01560. PMID: 32047429; PMCID: PMC6997149.
4: Ambrosini YM, Borcherding D, Kanthasamy A, Kim HJ, Willette AA, Jergens A, Allenspach K, Mochel JP. The Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review. Front Aging Neurosci. 2019 Jun18;11:130.    doi: 10.3389/fnagi.2019.00130. PMID: 31275138; PMCID: PMC6591269.
5: Schneider BK, Boyer A, Ciccolini J, Barlesi F, Wang K, Benzekry S, Mochel JP. Optimal Scheduling of Bevacizumab and Pemetrexed/Cisplatin Dosing in Non-Small
Cell Lung Cancer. CPT Pharmacometrics Syst Pharmacol. 2019 Aug;8(8):577-586. doi: 10.1002/psp4.12415. Epub 2019 May 9. PMID: 31004380; PMCID: PMC6709425.
6: Chandra L, Borcherding DC, Kingsbury D, Atherly T, Ambrosini YM, Bourgois- Mochel A, Yuan W, Kimber M, Qi Y, Wang Q, Wannemuehler M, Ellinwood NM, Snella
E, Martin M, Skala M, Meyerholz D, Estes M, Fernandez-Zapico ME, Jergens AE, Mochel JP, Allenspach K. Derivation of adult canine intestinal organoids for translational research in gastroenterology. BMC Biol. 2019 Apr 11;17(1):33. doi: 10.1186/s12915-019-0652-6. PMID: 30975131; PMCID: PMC6460554.
7: Sebbag L, Kirner NS, Allbaugh RA, Reis A, Mochel JP. Kinetics of Fluorescein in Tear Film After Eye Drop Instillation in Beagle Dogs: Does Size Really Matter? Front Vet Sci. 2019 Dec 19;6:457. doi: 10.3389/fvets.2019.00457. PMID: 31921915; PMCID: PMC6930880.
8: Klinedinst BS, Pappas C, Le S, Yu S, Wang Q, Wang L, Allenspach-Jorn K, Mochel JP, Willette AA. Aging-related changes in fluid intelligence, muscle and adipose mass, and sex-specific immunologic mediation: A longitudinal UK Biobank study. Brain Behav Immun. 2019 Nov;82:396-405. doi: 10.1016/j.bbi.2019.09.008. Epub 2019 Sep 9. PMID: 31513875.
9: Mochel JP, Ekker SC, Johannes CM, Jergens AE, Allenspach K, Bourgois-Mochel A, Knouse M, Benzekry S, Wierson W, LeBlanc AK, Kenderian SS. CAR T Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds Against Hematological Malignancies. AAPS J. 2019 Apr 8;21(3):50. doi: 10.1208/s12248-019-0322-1. PMID: 30963322.
10: Mochel JP, Teng CH, Peyrou M, Giraudel J, Danhof M, Rigel DF. Sacubitril/valsartan (LCZ696) significantly reduces aldosterone and increases cGMP circulating levels in a canine model of RAAS activation. Eur J Pharm Sci. 2019 Feb 1;128:103-111. doi: 10.1016/j.ejps.2018.11.037. Epub 2018 Nov 30. PMID: 30508581.
Publications Full-Texts: Link
NCBI Bibliography: Link
SMART Pharmacology: Link
ORCID: Link
 

Abstracts and Conference Papers (Last four years)

  1. Kingsbury D, Sun L, Qi Y, Fredericks J, Wang Q, Wannemuehler M, Mochel J, Jergens A, Allenspach K. Optimizing the Development and Characterization of Canine Small Intestinal Crypt Enteroids as a Research Model. International Society for Stem Cell Research Annual Meeting, Boston (2017).
  2. Kingsbury D, Sun L, Qi Y, Fredericks J, Wang Q, Wannemuehler M, Mochel J, Jergens A, Allenspach K. Optimizing the Development and Characterization of Canine Small Intestine Crypt Enteroids as a Research Model. International Congress of Mucosal Immunology, Washington (2017).
  3. Balbas-Martinez V, Allenspach K, Kingsbury D, Jergens AE, Troconiz I, Mochel JP. One Health: Translational and Reverse Translational Modeling of Inflammatory Bowel Disease using an advanced Boolean Network. 26th Population Approach Group in Europe (PAGE) Meeting, Budapest (2017).
  4. Smith JS, Mochel JP, Borts D, Haymond K, Schleining J, Coetzee JF. Pharmacokinetics of Fentanyl and Fentanyl Transdermal Patches in healthy and hospitalized Calves. American College of Veterinary Internal Medicine Forum, Washington (2017).
  5. Mochel JP. Modeling and Simulation: Shifting Gears to Accelerate Understanding of Variability in Animal and Translational Health. American Association of Veterinary Pharmacology and Therapeutics Biennial, Washington (2017).
  6. Kingsbury D, Fredericks J, Qi Y, Wang Q, Wannemuehler M, Mochel J, Jergens A, Allenspach K. Watch It Grow. The Original Dog Mini-Gut. ISU College of Veterinary Medicine Winter Symposium, Ames (2017).
  7.  Vessieres F, Kingsbury D, Jergens AE, Procoli F, Logue CM, Nolan LK, Du Y, Mochel JP, Li G, Simpson KW, Allenspach K. Specific Virulence Factors in Mucosa-Associated E. coli of Dogs With Inflammatory Bowel Disease (IBD) Predict Survival. European College of Veterinary Internal Medicine Congress, Malta (2017).
  8. Allenspach K, Mochel JP, Du Y, Priestnall S, Moore F, Slaytor M, Rodrigues A, Day M, Ackermann M, Krockenberger M, Mansell J, WSAVA GI Standardization Working Group, Suchodolski J, Berghoff N, Jergens AE. Correlating Gastrointestinal Histopathologic Findings to Clinical Disease Activity in Dogs with Idiopathic Inflammatory Bowel Disease. European College of Veterinary Internal Medicine Congress, Malta (2017).
  9. Sebbag L, Harrington D, Mochel JP. Tear Fluid Collection in Dogs and Cats Using Ophthalmic Sponges. American College of Veterinary Ophthalmology Conference, Baltimore (2017).
  10.  Mochel JP, Kingsbury D, Jergens AE, Allenspach K. Using Canine Intestinal Stem Cells to Advance Drug Development, Precision and Regenerative Medicine. ISU Faculty Research Symposium, Ames (2017)
  11. Smith JS, Zwueste D, Beahm A, Siegel K, Mochel JP, Winger K. Neurologic diseases of miniature companion pigs: 19 Cases (2000-2015). ISU Neuroscience Symposium, Ames (2017).
  12. Rowen NM, Mochel JP, Gannon M, Nelson M, LeVine DN. Regulation of Canine Neutrophil Extracellular Trap Formation by Immune-mediated Hemolytic Anemia Therapeutics. BIVI-NIH National Veterinary Scholars Symposium, Ames (2017).
  13. Hepner P, Sebbag L, Allbaugh R, Showman L, Perera A, Strong T, Mochel JP, Wiggans T, Maggs D. Merial-NIH National Veterinary Scholars Symposium, Ames (2017).
  14. Slagel C, Smith JS, Mochel JP, Plummer P. Concurrent use of an immunostimulant and antibiotic improves treatment outcome in a sheep model of catheter associated urinary tract disease due to Pseudomonas aeruginosa. BIVI-NIH National Veterinary Scholars Symposium, Ames (2017).
  15. McDowell W, Mochel JP, Showman L, Perera A, Hepner P, Sebbag L. Effect of tear collection method on total protein content and drug concentration in tear fluid of dogs and cats. NIH National Veterinary Scholars Symposium, Ames (2017).
  16.  Mochel J, Danhof M. Pharmacodynamics of the renin-angiotensin aldosterone system and blood pressure in relation to food intake in dogs. 25th Population Approach Group in Europe (PAGE) Meeting, Lisbon (2016).
  17.  Mochel J. Chronopharmacology of the renin-angiotensin network in dogs. The value of model-based approaches: some ‘food for thought’. International Seminar Programme on Drug Innovation, Utrecht (2016).
  18.  Mochel J, Seewald W, Danhof M. Pharmacokinetics of the angiotensin receptor-neprilysin inhibitor LCZ696 in furosemide-treated dogs. 13th European Association for Veterinary Pharmacology and Toxicology Congress, Nantes (2015).
  19.  Mochel J, Peyrou M, Giraudel J, Danhof M. First-in-class angiotensin receptor-neprilysin inhibitor LCZ696 markedly influences the dynamics of circulating cGMP and biomarkers of the renin-angiotensin aldosterone system in dogs. 13th European Association for Veterinary Pharmacology and Toxicology Congress, Nantes (2015).
  20. Mochel J. Chronopharmacology of the renin-angiotensin aldosterone system in dogs: the value of pharmacokinetic/pharmacodynamic modeling. 13th European Association for Veterinary Pharmacology and Toxicology Congress, Nantes (2015).
  21. Bieth B, Bornkamp B, Toutain C, Garcia R, Mochel J. Model-based dose-response analysis of furosemide effect on the renin-angiotensin cascade and diuresis in dogs. 13th European Association for Veterinary Pharmacology and Toxicology Congress, Nantes (2015).
  22. Pelligand L, Mochel J. Monte Carlo simulations and their application in veterinary medicine. 13th European Association for Veterinary Pharmacology and Toxicology Congress, Nantes (2015).
  23. Pelligand L, Soubret A, King JN, Elliot J, Mochel J. Simultaneous intravenous and subcutaneous population modelling of robenacoxib disposition kinetics in cats. 13th European Association for Veterinary Pharmacology and Toxicology Congress, Nantes (2015).
  24.  Mochel J, Bornkamp B, Bieth B. Evaluating the dose-response relationship of furosemide on diuresis and RAAS activation in dogs combining multiple comparisons and modeling techniques. 24th Population Approach Group in Europe (PAGE) Meeting, Hersonissos (2015).
  25.  Pelligand L, Renard D, Soubret A, King JN, Elliot J, Mochel J. Modeling of pharmacokinetic data using nonlinear mixed-effects: a paradigm shift in veterinary pharmacology. A case study with the nonsteroidal anti-inflammatory robenacoxib in cats. 24th Population Approach Group in Europe (PAGE) Meeting, Hersonissos (2015).
  26.  Mochel J, Burkey B, Fink M, Garcia R, Peyrou M, Giraudel J, Renard D, Danhof M. First-in-class angiotensin receptor neprilysin inhibitor LCZ696 modulates the dynamics of the renin cascade and natriuretic peptides system with significant reduction of aldosterone exposure. 63rd Annual Scientific Session of the American College of Cardiology, Washington (2014).
  27.  Mochel J, Renard D, Fink M, Danhof M. Daily variations of renin, urinary electrolytes and blood pressure are driven by food intake in dogs. 7th Symposium on Pharmacokinetics, Pharmacodynamics and Systems Pharmacology, Noordwijkerhout (2014).
  28.  Fink M, Mochel J, Gabrielsson J, Collard W, Gehring R, Laffont C, Liu Y, Martin-Jimenez T, Pelligand L, Steimer JL, Toutain PL, Whittem T, Riviere J. Animal Health Modeling & Simulation Society (AHM&S): A new society promoting model-based approaches for a better integration and understanding of quantitative pharmacology in Veterinary Sciences. 22nd Population Approach Group in Europe (PAGE) Meeting, Glasgow (2013).
  29.  Mochel J, Fink M, Peyrou M, Desevaux C, Deurinck M, Danhof M. Chronobiology of the renin-angiotensin-aldosterone system in Dogs: relation to blood pressure and renal physiology. 22nd Population Approach Group in Europe (PAGE) Meeting, Glasgow (2013).
  30.  Mochel J. Tuning in to body’s rhythms to adapt dosing schedules. International Cardiology Advisory Board Meeting, Zurich (2013)