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This laboratory is best known for its work on milk fever of dairy cattle. As a result much of our effort was on the transition dairy cow - the time from about 3 wks before calving until 3 wks after calving. This period represents the time of greatest risk of ilness for the dairy cow. Therefore we have been studying calcium and mineral homeostasis, immune suppression at the time of calving, and the interactions between nutrition and immunology and their effects on metabolic and infectious disease in transition dairy cows. Vitamin D insufficiency has been linked to increased predisposition to several forms of cancer as well as autoimmune disease. We are currently developing new forms of vitamin D that may effectively prevent/ treat colon cancer and inflammatory bowel disease. We have also been working with the problem of vitamin D deficiency in suckling and early weaned piglets. Dr. Nicholas Koszewski joined the lab in 2009 and has greatly advanced our ability to perform analysis of gene expression at the cellular and organismal level.
Dr. Goff has received several formal honors and awards during his career. Goff currently holds the Anderson Chair in Veterinary Medicine.
Reinhardt TA, Lippolis JD, McCluskey BJ, Goff JP, Horst RL. Prevalence of subclinical hypocalcemia in dairy herds. Vet J. 2010 Apr 28.