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BS- Cornell University, 1977
MS - Iowa State University, 1980
DVM- Iowa State University, 1984
PhD, Iowa State University, 1986
American College of Veterinary Nutrition, Honorary Diplomate, 2011
BMS 336- Veterinary Clinical Nutrition, 2 Cr hrs. Required of all 1st year professional students.
BMS 334 - Veterinary Histophysiology - teach section on Digestive Physiology
VDPAM 498 - teach section on metabolic diseases of dairy cattle. Elective for 4th year veterinary students.
This laboratory is best known for its work on milk fever of dairy cattle. As a result much of our effort was on the transition dairy cow - the time from about 3 wks before calving until 3 wks after calving. This period represents the time of greatest risk of ilness for the dairy cow. Therefore we have been studying calcium and mineral homeostasis, immune suppression at the time of calving, and the interactions between nutrition and immunology and their effects on metabolic and infectious disease in transition dairy cows. Vitamin D insufficiency has been linked to increased predisposition to several forms of cancer as well as autoimmune disease. We are currently developing new forms of vitamin D that may effectively prevent/ treat colon cancer and inflammatory bowel disease. We have also been working with the problem of vitamin D deficiency in suckling and early weaned piglets. Dr. Nicholas Koszewski joined the lab in 2009 and has greatly advanced our ability to perform analysis of gene expression at the cellular and organismal level.
Dr. Goff has received several formal honors and awards during his career. Goff currently holds the Anderson Chair in Veterinary Medicine.
Biomedical Sciences Governance Committee
CVM Academic Standards Committee
ISU Academic Standards Committee
American Dairy Science Association
American Association of Bovine Practitioners
American Association of Swine Veterinarians
Iowa Veterinary Medical Association
Nonnecke BJ, Waters WR, Goff JP, Foote MR. Adaptive immunity in the colostrum-deprived calf: response to early vaccination with Mycobacterium bovis strain bacille Calmette Guerin and ovalbumin. J Dairy Sci. 2012 Jan;95(1):221-39.
Goff JP, Koszewski NJ, Haynes JS, Horst RL. Targeted delivery of vitamin D to the colon using β-glucuronides of vitamin D: therapeutic effects in a murine model of inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol. 2011
Reinhardt TA, Lippolis JD, McCluskey BJ, Goff JP, Horst RL.
Prevalence of subclinical hypocalcemia in dairy herds. Vet J. 2010 Apr 28.
Bannerman DD, Springer HR, Paape MJ, Kauf AC, Goff JP. Evaluation of breed-dependent differences in the innate immune responses of Holstein and Jersey cows to Staphylococcus aureus intramammary infection. J Dairy Res. 2008 Aug; 75(3):291-301.
Bannerman DD, Kauf AC, Paape MJ, Springer HR, Goff JP. Comparison of Holstein and Jersey innate immune responses to Escherichia coli intramammary infection. J. Dairy Sci. 2008 Jun; 91(6):2225-35.
Kimura K, Goff JP, Schmerr MJ, Stabel JR, Inumaru S, Yokomizo Y. Activation of immune cells in bovine mammary gland secretions by zymosan-treated bovine serum. J Dairy Sci. 2008 May; 91(5):1852-64.
Goff JP. The monitoring, prevention, and treatment of milk fever and subclinical hypocalcemia in dairy cows. Vet J. 2008 Apr;176(1):50-7.
Goff JP, Brummer EC, Henning SJ, Doorenbos RK, Horst RL. Effect of application of ammonium chloride and calcium chloride on alfalfa cation-anion content and yield. J Dairy Sci. 2007 Nov; 90(11):5159-64.
Kimura K, Reinhardt TA, Goff JP. Parturition and hypocalcemia blunts calcium signals in immune cells of dairy cattle. J Dairy Sci. 2006 Jul; 89(7):2588-95.
Lippolis, J.D., T.A. Reinhardt, J.P. Goff, and R.L. Horst. 2006. Neutrophil extracellular trap formation by bovine neutrophils is not inhibited by milk. Vet Immunol Immunopathol. 113(1-2):248-55.
Kimura, K., T.A. Reinhardt and J.P. Goff. 2006. Parturition and hypocalcemia blunts calcium signals in immune cells of dairy cattle. J. Dairy Sci. 89(7):2588-95.
Hammon, D.S., I.M. Evjen, T.R. Dhiman, J.P. Goff, and J.L. Walters. 2006. Neutrophil function and energy status in Holstein cows with uterine health disorders. Vet Immunol Immunopathol. 113(1-2):21-9.
Goff, J.P. 2006. Major advances in our understanding of nutritional influences on bovine health. J. Dairy Sci. 89(4):1292-301.
Melendez, P., J.P. Goff, C.A. Risco, L.F. Archbald, R.C. Littell, and G.A. Donovan. 2006. Effect of administration of a controlled-release monensin capsule on incidence of calving-related disorders, fertility, and milk yield in dairy cows. Am. J. Vet. Res. 67(3):537-43.
Melendez, P., J.P. Goff, C.A. Risco, L.F. Archbald, R. Littell, and G.A. 2006. Donovan. Incidence of subclinical ketosis in cows supplemented with a monensin controlled-release capsule in Holstein cattle, Florida, USA. Prev. Vet. Med. 73(1):33-42.
Harp, J.A., T.E. Waters, J.P. Goff, D.D. Bannerman, and M.J. Paape. 2006. Expression of lymphocyte homing and adhesion molecules during intramammary infection of cows with Serratiamarcescens or Streptococcusuberis: correlation with bacterial colonization and clinical signs. Vet Immunol Immunopathol. 109(1-2):13-21.