Mark R Ackermann

DVM, PhD, Diplomate ACVP
Education & Certifications  

1990 Diplomate, American College of Veterinary Pathologists (ACVP; Specialty Board Certification in the Clinical Specialty of Veterinary Pathology)

1989 PhD, Veterinary Pathology, ISU

1986 DVM, ISU

Research Focus & Interests  

Dr. Mark R. Ackermann is professor in the Department of Veterinary Pathology in the College of Veterinary Medicine with research, clinical service in surgical and post-mortem pathology, and teaching responsibilities. 

Dr. Ackermann’s laboratory investigates respiratory syncytial virus (RSV) infection in newborn lambs as a model for RSV infection in infants.  His team has determined the effects of preterm birth, in utero stresses (e.g., alcohol/nicotine) on RSV disease severity and also identified key innate and adaptive immune responses that underlie susceptibility to RSV infection in the preterm and term lung.  They have used this model to test therapeutic interventions such as the enhancement of the dual functioning oxidase/lactoperoxidase innate defense system, administration of vascular endothelial growth factor (VEGF), and the effects of other small molecule therapeutics.  There are no fully effective treatments for RSV and Ackermann’s laboratory are currently testing promising drugs against RSV that have also entered or are entering human clinical trials.  In addition, the team has determined the lambs, like infants, developed enhanced RSV disease following vaccination with formalin-inactivated RSV vaccine.  Major funding has included the NIH, USDA, Salsbury Endowment, Carver Foundation, pharmaceutical and biotechnology companies.  Dr. Ackermann's previous work involved molecular and innate immunity, including work on Mannheimia haemolytica, an important pathogen in shipping fever of cattle and sheep, along with his work on bovine leukocyte adhesion deficiency (BLAD) in Holstein cattle.

Dr. Ackermann also is engaged in clinical service (diagnostic pathology) and has diagnostic expertise in respiratory diseases and gastrointestinal disease.  He has served as Interim Associate Dean of Research and Acting Chair of Veterinary Clinical Sciences as well as the J.G. Salsbury Endowed Chair and served on NIH study sections and USDA review panels.  Dr. Ackermann teaches veterinary medical students in clinical rotations, graduate students, and post doctoral candidates and is Director of the Summer Scholar Research Program for veterinary medical students.  Currently, as Interim Assistant Dean he developed seminars introducing first year veterinary medical students to biomedical research and served as PI for the NIH T 35 renewal at ISU.  He has been active in the American College of Veterinary Pathologists (ACVP) professional organization serving on various committees and is currently Secretary/Treasurer of the ACVP.

Honors & Awards  

Federal Laboratory Consortium for Technology Transfer Award (1996)

Outstanding/Superior Ratings and Certificates of Merit, USDA/NADC (1989-95)

Review Team Member (one of four), USDA-CSREES Review of Virginia-Maryland Regional College of Veterinary Medicine, (October, 1998)

Panel Reviewer, USDA/NRI-Competitive Grants Program (CGP), CSREES (1998)

American College of Veterinary Pathologists (ACVP) member (1990-present)

American Veterinary Medical Association (AVMA) member (1986-present)

Editorial Board, Veterinary Pathology (1995-97, 2005-2007)

Board of Scientific Reviewers, American Journal of Veterinary Research (1992-95)

William O. Reece Student Advisor of the Year (2005)

J.G. Salsbury Endowed Chair, (2001-2004) and (2005-2007)

Promotion to Professor with Distinction (2002)

AVMF Bovine Research Excellence Award (2002)

Pfizer Award for Research Excellence (2000 and 2010)

Session Chair, Experimental Biology 2005, ACVP/ASIP joint symposium, San Diego, CA (2005)

Plenary Session Chair:  Innate Immunity by Epithelia, ACVP meeting, Tucson, AZ (2006)

Plenary Session Co-Chair: Mechanism of Asthma, ACVP meeting, Seattle, WA (2012)

The ACVP Experimental Disease Scientific Session, Co-Chair (2006), Chair (2007)

The ACVP Scientific Symposium committee (TASS) committee member (2004-2008)

The ACVP Scientific Symposium committee (TASS) committee chair (2006-2008)

The ACVP Government Policy Committee (2005-2007)

The ACVP Examination Committee, (2004-2005; proctor); (2006-present; full committee and general pathology section leader)

American Society of Investigative Pathology (ASIP) Program Committee Annual Meetings at Experimental Biology (2004, 2005, 2006)

Ad Hoc Grant Reviewer, USDA/NRI-CGP (yearly; 1992-present); Canadian Competitive Grant Program (NSERC)  (2004, 2009, 2011); The Wellcome Trust, England, for Grant Proposal (1997); Arthritis Research Campaign, England, for Grant Proposal (2001); The Thrasher Research Fund (2006); The University of Iowa, Center for Gene Therapy of Cystic Fibrosis (2006)

Panel Chair, Project Reviews, NP 103 Panel K, Zoonotic Risks, National Programs, USDA-ARS, 2011

NIH Study Section Reviewer (2007), Ad hoc, NIAID, Biodefense

NIH Study Section Reviewer (2008), Ad hoc, NIAID, Cellular and Molecular Immunology-B

NIH Study Section Reviewer (2006-present), NIAID, Innate Immunity (Inflammation); regular member (2008-2012)

NIH III study section, ad hoc reviewer (2013)

NIH IRIDA (International Research in Infectious Diseases), ad hoc reviewer (2013)

NIH Study Section Reviewer (2014) ZRG1 IDM Special Emphasis Panel for Research in Biomedicine and Agriculture Using Agriculturally Important Domestic Species.

NIH Study Section Reviewer (2014), ad hoc Lung Cellular, Molecular, and Immunobiology Study Section

NIH Study Section Reviewer (2015), U19 Study Section (Special Emphasis Panel) Human Immunology Project Consortium

NIH Study Section Reviewer (2016), ad hoc NIAID Innate Immunity (Inflammation)

NIH Study Section Reviewer (2017), NIAID Program Project (P01) grants

 2016-present Interim Assistant Dean for Research and Graduate Studies
 2013-2014 Acting Chair, Department of Veterinary Clinical Sciences, ISU
 2011-2012 Interim Associate Dean for Research and Graduate Studies, ISU
 2011-present Consultant pathologist, Texas A&M Gastroenterology Lab
 2004-2007 J.G. Salsbury Endowed Chair (renewed), ISU
 2003-present Consultant pathologist, Antech Diagnostics, New York
 2002-present Professor, Department of Veterinary Pathology, ISU
 2001-2004 J.G. Salsbury Endowed Chair, ISU
 1998-2002 Associate Professor, Department of Veterinary Pathology, ISU
 1996-1998 Assistant Professor, Department of Veterinary Pathology, ISU
 1996-present Professor-in-Charge, Image Analysis Facility, ISU
 1994-1995 Interim Research Leader, Avian and Swine Respiratory Disease Research, USDA/ARS-National Animal Disease Center (NADC), Ames, IA
 1992-1996 Collaborative Assistant Professor, Departments of Pathology and Anatomy, ISU
 1992-1996 Consultant Pathologist, NOBL Laboratories, Inc., Sioux Center, Iowa
 1992 Consultant Pathologist, Dr. J.P. Tappe, Pal Pathology, Inc., Dallas, Texas
 1988-1996 Lead Scientist, Swine Respiratory Disease Project, USDA/ARS-NADC
 1987-1988 Veterinary Medical Officer, Avian Colisepticemia Project, Pathology, USDA/ARS-NADC
 1986-1987 Postdoctoral Research Associate, Department of Veterinary Pathology, ISU
Selected Publications  

Lazic T, Matic M, Gallup JM, van Geelen A, Meyerholz DK, Grubor B, Imerman PM, Almeida de Macedo MM, Ackermann MR:  Effects of nicotine on pulmonary surfactant proteins A and D in ovine lung epithelia.  Pediatr Pulmonol 45:255-262, 2010 PMCID: PMC 2981073

Radi ZA, Meyerholz DK, Ackermann MR:  Pulmonary cyclooxygenase-1 (COX-1) and COX-2 cellular expression and distribution after respiratory syncytial virus and parainfluenza virus infection.  Viral Immunol 23(1):43-48, 2010 PMCID: PMC2883516

Olivier A, Gallup JM, van Geelen A, Ackermann MR: Exogenous administration of vascular endothelial growth factor prior to human respiratory syncytial virus A2 infection reduces pulmonary pathology in neonatal lambs and alters epithelial innate immune responses.  Exp Lung Res 37:131-143, 2011 PMCID:  PMC3169812

Sow FB, Gallup JM, Olivier A, Krishnan S, Patera AC, Suzich J, Ackermann MR: Respiratory syncytial virus is associated with an inflammatory response in lungs and architectural remodeling of lung-draining lymph nodes of newborn lambs.  Am J Physiol Lung Cell Mol Physiol 300:L12-24, 2011 PMCID:  PMC3023288

Sow FB, Gallup JM, Krishnan S, Patera AC, Suzich J, Ackermann MR:  Respiratory syncytial virus infection is associated with an altered innate immunity and a heightened pro-inflammatory response in lungs of preterm lambs.  Respir Res 12:106-118, 2011 PMCID:  PMC3170232

Radi Z, Ackermann MR:  Ontogeny of pulmonary cyclooxygenase-1 (COX-1) and -2 (COX-2).  Pathophysiology 18:215-219, 2011 AM

Lazic T, Sow FB, van Geelen A, Meyerholz DK, Gallup JM, Ackermann MR:  Exposure to ethanol during the last trimester of pregnancy alters the maturation and immunity of fetal lung.  Alcohol 45:673-680, 2011 PMCID:  PMC3184311

Sow FB, Gallup JM, Derscheid R, Krishnan S, Ackermann MR:  Ontogeny of the immune response in the ovine lung. Immunological Investigations 41:304-316, 2012

Derscheid RJ, Ackermann MR:  Perinatal lamb model of respiratory syncytial virus (RSV) infection.  Viruses 4:2359-2378, 2012 PMCID:  PMC3497056

Derscheid RJ, Ackermann MR:  The innate immune system of the perinatal lung and responses to respiratory syncytial virus infection. Vet Pathol 50:827-841, 2013

Derscheid RJ, van Geelen A, Berkebile AR, Gallup JM, Hostetter SJ, Banfi B, McCray Jr PB, Ackermann MR:  Increased concentration of iodide in airway secretions is associated with reduced RSV disease severity. Am J Respir Cell Mol Biol (Epub), 2013

Derscheid RJ, Gallup JM, Knudson CJ, Varga SM, Grosz DD, van Geelen A, Hostetter J, Ackermann MR:  Effects of formalin-inactivated respiratory syncytial virus (FI-RSV) in the perinatal lamb model of RSV.  PLOS One 8(12):e81472, 2013

Derscheid RJ, van Geelen A, McGill JL, Gallup JM, Cihlar T, Sacco RE, Ackermann MR:  Human respiratory syncytial virus Memphis 37 grown in HEp-2 cells causes more severe disease in lambs than virus grown in Vero cells.  Viruses. 5(11):2881-97, 2013

Sacco RE, McGill JL, Pillatzki AE, Palmer MV, Ackermann MR:  Respiratory syncytial virus infection in cattle.  Vet Pathol 51, (2):427-436, 2014

Grosz D, van Geelen A, Gallup JM, Hostetter SM, Derscheid RJ, Ackermann MR:  Sucrose stabilization of respiratory syncytial virus (RSV) during nebulization and experimental infection BMC Research Notes, 7:158, 2014 PMCID: PMC3995326

Ackermann MR:  Lamb model of respiratory syncytial virus-associated lung disease: Insights to pathogenesis and novel treatments.  Institute for Laboratory Animal Research (ILAR) Journal 55:4-15, 2014 PMCID:  PMC4158344

Larios A, Detalle L, Gallup JM, van Geelen A, Stohr T, Ackermann MR:  Kinetics of respiratory syncytial virus (RSV) Memphis strain 37 (M37) infection in the respiratory tract of newborn lambs as an RSV infection model for human infants.  PLOS One 10 (12): e0143580. doi: 10.1371/journal.pone.0143580. eCollection 2015.

Roymans D, Battles MB, Rigaux P, Gallup JM, Furmanova-Hollenstein P, Van den Berg J, Kwanten L, Van Ginderen M, Verheyen N, Vranckx L, Jaensch S, Arnoult E, Voorzaat R, Huntjens D, Crabbe M, Raboisson P, Langedijk JP, Ackermann MR, McLellan JS, Vendeville S, Koul A:  JNJ-53718678 efficiently inhibits respiratory syncytial virus by preventing triggering of the fusion glycoprotein Nature Microbiol (accepted), 2017