Gunnar R Mair

Assistant Professor
2020 Vet Med
Education & Certifications  
  • PhD, 1998, Molecular Parasitology, Queen's University Belfast
  • BMS/TOX 575 - Cell Biology
Selected Publications  


1. Santos JM, Egarter S, Zuzarte-Luís V, Kumar H, Moreau CA, Kehrer J, Pinto A, Costa MD, Franke-Fayard B, Janse CJ, Frischknecht F, Mair GR. Malaria parasite LIMP protein regulates sporozoite gliding motility and infectivity in mosquito and mammalian hosts. eLIFE 2017 May 2;6. pii: e24109. doi: 10.7554/eLife.24109.

2. Kehrer J, Frischknecht F, Mair GR. Proteomic analysis of the Plasmodium berghei gametocyte egressome and vesicular bioID of osmiophilic body proteins identifies merozoite TRAP-like Protein (MTRAP) as an essential factor for parasite transmission. Molecular and Cellular Proteomics 2016 Jul 1. pii: mcp.M116.058263.

3. Kehrer J, Lemgruber L, Silva PAGC, Frischknecht F, Mair GR. A Putative Small Solute Transporter Is Responsible for the Secretion of G377 and TRAP- Containing Secretory Vesicles during Plasmodium Gamete Egress and Sporozoite Motility. PLoS Pathogens 2016 Jul 18;12(7):e1005734

4. Rao P, Santos JM, Pain A, Templeton TJ, Mair GR. Translational repression of the cpw-wpc gene family in the malaria parasite Plasmodium. Parasitology International 2016 Jun 13. pii: S1383-5769(16)30068-X. doi: 10.1016/j.parint.2016.06.007.

5. Lasonder E, Rijpma SR, van Schaijk BCL, Hoeijmakers WAM, Kensche PR, Gresnigt MS, Italiaander A, Vos MW, Woestenenk R, Bousema T, Mair GR, Khan SM, Janse CJ, Bártfai R, Sauerwein RW. Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression. Nucleic Acids Research 2016 Jul 27;44(13):6087-101.

6. Santos JM, Duarte N, Kehrer J, Ramesar J, Avramut MC, Koster AJ, Dessens JT, Frischknecht F, Janse CJ, Franke-Fayard B, Mair GR. Maternally supplied S- acyl-transferase is required for crystalloid organelle formation and transmission of the malaria parasite. Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 28;113(26):7183-8.

7. Klug D, Mair GR, Frischknecht F, Douglas R. A small mitochondrial protein present in myzozoans is essential for malaria transmission. Open Biology 2016 Apr; 6(4)

8. Kumar H, Frischknecht F, Mair GR, Gomes J. In silico identification of genetically attenuated vaccine candidate genes for Plasmodium liver stage. Infection,Genetics and Evolution 2015 Nov 17;16:249.

9. Singer M, Marshall J, Heiss K, Mair GR, Grimm D, Mueller A-K, Frischknecht F. Zinc finger nuclease-induced double strand breaks attenuate malaria parasites and reveal rare micro-homology mediated end joining. Genome Biology 2015 Nov 17;16:249

10. Santos JM, Kehrer J, Franke-Fayard B, Frischknecht FF, Janse CJ, Mair GR. The Plasmodium palmitoyl-S-acyl-transferase DHHC2 is essential for ookinete morphogenesis and malaria transmission. Scientific Reports 2015 Nov 3;5:16034

11. Inácio P, Zuzarte-Luís V, Ruivo MT, Falkard B, Nagaraj N, Rooijers K, Mann M, Mair G, Fidock DA, Mota MM. Parasite-induced ER stress response in hepatocytes facilitates Plasmodium liver stage infection. EMBO Reports 2015 Aug;16(8):955-64

12. Guerreiro A, Deligianni E, Santos JM, Silva PAGC, Pain A, Janse CJ, Carret CK, Sidén-Kiamos I, Mair GR. Genome-wide RIP-Chip analysis of translational repressor-bound mRNAs in the Plasmodium gametocyte. Genome Biology 2014 Nov 3;15(11):493.

13. Silva P, Guerreiro A, Santos J, Braks JAM, Janse CJ, Mair GR‡. Translational Control of UIS4 Protein of the Host-Parasite Interface is Mediated by the RNA Binding Protein Pumilio-2 in Plasmodium berghei Sporozoites. PLoS ONE 2016 Jan 25;11(1)

14. Andreadaki M, Morgan RN, Deligianni E, Kooij TWA, Santos JM, Spanos L, Matuschewski K, Louis C, Mair GR, Siden-Kiamos I. Genetic crosses and complementation reveal essential functions for the Plasmodium stage-specific actin2 in sporogonic development. Cellular Microbiology. 2014 May;16(5):751- 67.

15. Hanson K, Mair GR. Stress granules and malaria liver stage infection. Biology Open. 2014 Jan 15;3(1):103-7..

16. Ngwa CJ, Scheuermayer M, Mair GR, Kern S, Aminake MN, Brügl T, Wirth C, Wiesner J, Fischer R, Vilcinkas A, Pradel G. Changes in the transcriptome of the malaria parasite Plasmodium falciparum during its transmission from the human to the mosquito. BMC Genomics 2013 Apr 15;14:256.

17. Lin J-w, Meireles P, Prudêncio M, Engelmann S, Annoura T, Sajid M, Chevalley- Maurel S, Ramesar J, Nahar C, Avramut CMC, Koster AJ, Matuschewski K, Waters AP, Janse CJ, Mair GR, Khan SM. Loss-of-function analyses define vital and redundant functions of the Plasmodium rhomboid protease family. Molecular Microbiology. 2013 Mar 12; 88(2):318-338.

18. Mwai L, Diriye A, Masseno V, Muriithi S, Feltwell T, Musyoki J, Lemieux J, Feller A, Mair GR, Marsh K, Newbold C, Nzila A, Carret CK. Genome-wide adaptations of Plasmodium falciparum in response to lumefantrine selective drug pressure. PLoS ONE. 2012;7(2):e31623. Epub 2012 Feb 27.

29. Laurentino EC, Taylor S, Mair GR, Lasonder E, Bartfai R, Stunnenberg HG, Kroeze H, Ramesar J, Franke-Fayard B, Khan SM, Janse CJ, Waters AP. Experimentally controlled downregulation of the histone chaperone FACT in Plasmodium berghei reveals that it is critical to male gamete fertility. Cellular Microbiology 2011 Dec; 13(12):1956-74.