The purpose of this study is to evaluate the safety and effectiveness of a new treatment to enhance response to radiation therapy for dogs with stage 3 and 4 intranasal adenocarcinoma.
- Must weigh at least 11lbs.
- Must have Stage 3 or Stage 4 Intranasal Adenocarcinoma.
- Must not have metastatic disease.
- Must not have tumor invading facial skin surface.
- Must not have prior chemotherapy or radiation therapy.
Your dog will be received 5 daily (Monday-Friday) fractions of palliative-intent radiation therapy, administered under general anesthesia, as this is the standard of care for canine nasal tumors. Prior to each radiation treatment, either the investigational treatment or a placebo will be administered intravenously. Your dog will be required to return to the clinic for a recheck appointment 4 weeks later. At week 13 post-treatment, a skull CT will be performed to evaluate the tumor response. Additionally, you will be requested to complete questionnaires regarding your dog's quality of life throughout the study.
The study will cover up to $7,500 for the cost of IVP and treatment. An estimate of costs for which you will be responsible will be prepared for you at the time of admission.
Oncology Service at 515-294-4900