VPATH Comparative Pathology Core Service

The CPC provides pathology support for research projects involving animal models. This includes gross and microscopic pathology, clinical pathology, special imaging, photography and data analysis. The CPC provides service to investigators both within and outside Iowa State University and can assist with a broad range of preclinical studies in a wide range of species. Studies that CPC has completed include toxicology, vaccine studies, infectious disease, nutritional physiology, neoplastic disease, musculoskeletal disease and developmental disorders. Please contact Rachel Phillips for more information or fill out this request for service form and email to rlp79@iastate.edu.



  • Gross examination
  • Tissue collection
  • Gross lesion scoring
  • Histopathology
  • Microscopic lesion scoring
  • Special stains

Clinical Pathology

  • CBC and serum biochemical analysis
  • Cytologic examination
  • Urinalysis

Special Imaging

  • Immunohistochemstry
    • Fluorescence
    • Chromogenic
  • In Situ Hybridization – RNAscope
  • Hyperspectral microscopy


  • Gross and microscopic images
  • Fluorescent and chromogenic IHC
  • Formatting for publication

Data Analysis and Report Generation

  • HALO Image Analysis software
  • Morphometrics

Data from CPC may not be submitted for safety/efficacy to FDA, CVB, EPA, NCI/ other federal agency

Featured Service

In Situ Hybridization - RNAscope

RNAScope-Advanced Cell Diagnostics graph
RNAscope single colorRNAscope two-color
Top: RNAscope single color ISH for porcine Il-β. Bottom: RNAscope two color for ISH for γδT cells and TGF-β

This is a new method for in situ hybridization that yields a strong, specific, readable signal (see figures below) using formalin fixed / paraffin embedded or frozen  tissues. Species specific probes can be designed for multiple species including bovine, porcine, canine, equine and murine. Please contact us to find out if this technology may be helpful in your research project.

Comparative Pathology Core Services logo

Mission: Provide high quality pathology support to researchers using animal models.

Contact Information:

Rachel Phillips
Assistant Scientist II

Amanda Fales-Williams
Faculty Contact

Joe Haynes
Faculty Contact