Evaluation of Jejunal Mucosa using Capsule Endoscopy in dogs with Inflammatory Bowel Disease and Jejunal Lymphadenopathy

Purpose of Study: 

Inflammatory Bowel disease (IBD) is considered to be the most common cause of vomiting and diarrhea in dogs. It is characterized by chronic inflammation of the gastrointestinal (GI) tract, causing persistent, recurrent signs such as vomiting and diarrhea. The exact cause of this disease is currently unknown, but it is thought that diet, infectious agents, genetics and abnormalities of the immune system play a role.

Adbominal Ultrasound is part of the routine diagnostic workup for this disease, and a commun finding in IBD dogs is enlarged Jenunal Lymph Nodes (Jejunal Lymphadenopathy). Althought no clear clinical significance has been identified, it is possible that this Lymphadenopathy suggests more pronounced disease.

Purpose of this Study: We wish to use Capsule Endoscopy (a small camera contained in a capsule) to assess if dogs with enlarged Jejunal Lymph Nodes and Inflammatory Bowel Disease have more severe lesions on their mucosa than dogs without enlarged Lymph Nodes.  We will then compare the results from the Capsule Endoscopy to those from the traditional Endoscopy.

Eligibility: 

Your dog may qualify for this study if:

  • He/She is greater than 22 Lbs in weight.
  • Other underlying causes for gastrointestinal signs have been be ruled out based on labwork and abdominal imaging.
  • You agree to collect and return the endoscopy capsule if it is not passed while your pet is in the hospital.
Client Responsibilities: 

In this study,  we will administer a small capsule that contains a camera that is capable of film the inside of your dog’s intestines.

Your dog will need to be fasted for 16 hours before and 8 hours after the capsule is given. The capsule will be voided naturally in your dog’s stool and we will collect the capsule from his stool. 

The next day your dog will undergo a traditional Endoscopy, and we'll compare the findings of the two techniques. Please note that the traditional Endoscopy is part of the usual diagnostic workup for Inflammatory Bowel Disease, and your dog should undergo this procedure regardless of his/her participation in this study.

Client Benefits: 

This study will cover the costs of the Capsule Endoscopy as well as labwork (CBC, chemistry, urinalysis and GI panel) and the time in hospital for your dog.

You will be responsible for any costs associated with the normal course of treatment, the treatment of any complications that may arise, and unrelated medical conditions.

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