The Translational and One Health program embraces the One Health concept and has been leading the university-wide research effort on Translational and One Health. This program is strategically important for ISU and has been one of the President’s High Impact Hire Initiatives, resulting in hiring of new faculty members who conduct Translational/One Health research. Research areas include zoonotic and emerging diseases; development of animal models for studying human diseases such as platelet disorders, retinopathies, and cancer; development of medical devices; comparative ophthalmology; locomotive disturbances; spinal cord injury; immunotherapies; and gastrointestinal and respiratory diseases. The CVM leads the university-wide effort on the development of novel vaccines against infectious agents that are important for animal and human health, such as HIV, influenza, PEDV, PRRS, and biodefense agents. The CVM is a major partner for the university-wide Nanovaccine Institute http://www.nanovaccine.iastate.edu/.