David E Verhoeven

Research Assistant Professor
1090 Vet Med
Education & Certifications  


Research Focus & Interests  
Defining immune responses to mucosal pathogens, respiratory bacterial vaccines, viral/bacterial co-infections of the lungs, viral induced immunopathology (influenza and RSV), pediatric immunology, CD4 T-cell responses to respiratory pathogens and HIV.


Selected Publications  

Teijaro JR, Verhoeven D, Page CA, Turner D, Farber DL.Memory CD4 T cells direct protective responses to influenza virus in the lungs through helper-independent mechanisms. J Virol. 2010 Sep;84(18):9217-26.  PMC2937635

Verhoeven D, Nesselbush M, Pichichero M.  Lower Nasopharyngeal Epithelial Cell Repair and Diminished Innate Inflammation Responses Contribute to the Onset of Acute Otitis Media in Otitis-Prone Children.  Medical Microbiology and Immunology.  2013. Aug;202(4):295-302 PMC3943207

Verhoeven D, Perrry S, Pichichero M.  Vaccination with Streptococcus pneumonia trivalent protein vaccine containing PcpA, PhtD, and PlyD protects against sepsis and lethal pneumonia in an infant murine model.  Vaccine.  2014. 32(26):3205-10

Verhoeven D, PIchichero M.  Divergent mucosal and systemic responses in children in response to acute otitis media.  Clin. Exp Immunol.  2014.  Oct;178(1):94-101

Verhoeven, D, George MD, Hu W, Dange AT, Smit-McBride, Reay E, Macal M, Sankaran W, Dandekar S.  Enhanced innate antiviral gene expression, IFN-α, and cytolytic responses are predictive of mucosal immune recovery during simian immunodeficiency virus infection. Journal of Immunology.  2014 Apr 1;192(7):3308-18

Verhoeven et al.  Vaccination with  Streptococcus pneumoniae Monovalent Recombinant Protein Vaccine Candidates PcpA, PhtD and PlyD1 Protects against Sepsis and Lethal Pneumonia during Heterologous Challenge in an Infant Murine Model.  Journal of Clinical Immunology.  2014. Aug;21(8):1037-45

 Verhoeven, D. Xu Q, Pichichero M.  Lower adaptive immune responses to RSV contributes to higher frequencies of acute media in otitis prone children.  Clinical Infectious Diseases.  2014. Aug;59(3):376-83. PMC4155442