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Joshua R Beck

PhD
Joshua R Beck

Associate Professor
Biomedical Sciences
jrbeck@iastate.edu
515-294-8293
2086 Patterson
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Education & Certifications

  • PhD, Microbiology, Immunology, and Molecular Genetics, 2012, University of California, Los Angeles
  • BS, Microbiology and Biochemistry, 2004, Iowa State University

Teaching

  • 2018-present, BMS 7335/5350: Molecular & Cellular Basis of Disease
  • 2018-present, BMS 6880: Research Review
  • 2017-present, BMS 7443/5430: Pharmacology & Therapeutics

Selected Publications

Full NCBI bibliography

Blauwkamp JA, Ambekar SV, Hussain T, Mair GR, Beck JR, Absalon S. Nuclear pore complexes undergo Nup221 exchange during blood stage asexual replication of Plasmodium parasites. mSphere. 2024 Dec 19;9(12):e0075024. PubMed PMID: 39526784

Fierro MA, Muheliji A, Sha J, Wohlschlegel JA, Beck JR. PEXEL is a proteolytic maturation site for both exported and non-exported Plasmodium proteins. mSphere. 2024 Feb 9 9:e0039323. PubMed PMID: 38334391.

Fierro MA, Hussain T, Campin LJ, Beck JR. Knock-sideways by inducible ER retrieval enables a unique approach for studying Plasmodium-secreted proteins. PNAS. 2023 Aug 15;120(33):e2308676120. PubMed PMID: 37552754.

Hussain T, Linera-Gonzalez J, Beck JM, Fierro MA, Mair GR, Smith RC, Beck JR. The PTEX pore component EXP2 is important for intrahepatic development during the Plasmodium liver stage. mBio. 2022 Nov 29;e0309622. PubMed PMID: 36445080.

Chheda P, Nieto N, Kaur S, Beck JM, Beck JR, Kerns R, Honzatko, RB, Nelson SW. Promising antimalarials targeting apicoplast DNA polymerase from Plasmodium falciparum. Eur J Med Chem. 2022 Dec 5;243:114751. PubMed PMID: 36191407.

Ambekar S, Beck JR, Mair GR. TurboID identification of evolutionarily divergent components of the nuclear pore complex in the malaria model Plasmodium berghei. mBio. 2022 Oct 26;13(5):e0181522. PubMed PMID: 36040030.

Kaur S, Nieto N, McDonald P, Beck JR, Honzatko, RB, Nelson SW. Discovery of small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase. J Enzyme Inhib Med Chem. 2022 Dec;37(1):1320-1326. PubMed PMID: 35514163.

Ho CM, Jih J, Lai M, Li X, Goldberg DE, Beck JR, Zhou ZH. Native structure of the RhopH complex, a key determinant of malaria parasite nutrient acquisition. PNAS. 2021;118(35):e2100514118. PubMed PMID: 34446549.

Garten M and Beck JR. Structured to conquer: transport across the Plasmodium parasitophorous vacuole. Curr Opin Microbiol. 2021 Aug 7;63:181-188. PubMed PMID: 34375857.

Beck JR and Ho CM. Transport mechanisms at the malaria parasite-host cell interface. PLoS Pathog. 2021 Apr 1;17(4): e1009394. PubMed PMID: 33793667.

Garten M, Beck JR, Roth R, Tenkova-Heuser T, Heuser J, Istvan E, Bleck CKE, Goldberg DE, Zimmerberg J. Contacting domains segregate a lipid transporter from a solute transporter in the malarial host-parasite interface. Nature Communications. 2020 Jul 30;11(1):3825. PubMed PMID: 32732874.

Nessel T, Beck JM, Rayatpisheh S, Jami-Alahmadi Y, Wohlschlegel JA, Goldberg DE, Beck JR. EXP1 is required for organization of EXP2 in the intraerythrocytic malaria parasite vacuole. Cellular Microbiology. 2020 Jan 28:e13168. PubMed PMID: 31990132.

Matz JM, Beck JR, Blackman MJ. The parasitophorous vacuole of the blood-stage malaria parasite. Nature Reviews Microbiology. 2020 Jan 24. PubMed PMID: 31980807.

Ho CM, Beck JR, Lai M, Cui Y, Goldberg DE, Egea PF, Zhou ZH. Malaria parasite translocon structure and mechanism of effector export. Nature. 2018 Sep;561(7721):70-75. PubMed PMID: 30150771.

Garten M, Nasamu AS, Niles JC, Zimmerberg J, Goldberg DE, Beck JR. EXP2 is a nutrient-permeable channel in the vacuolar membrane of Plasmodium and is essential for protein export via PTEX. Nature Microbiology. 2018 Oct;3(10):1090-1098. PubMed PMID: 30150733.