Michael Cho

PhD
Professor
Biomedical Sciences
515-294-6449
2022 Patterson Hall
ISU Directory Link
Education & Certifications  
  • BA, Biology and Chemistry, 1987, Whitman College, Walla Walla, Washington
  • PhD, Cellular, Viral and Molecular Biology, 1994, University of Utah, School of Medicine, Salt Lake City, Utah
Teaching  
  • BMS 502, Methods in Biomedical Sciences
  • BMS 575, Cell Biology
  • BMS 599, Creative Component
  • BMS 698, Seminars in Biomedical Sciences
Research Focus & Interests  
  • Structure-function of viral envelope glycoproteins
  • virus-host interactions
  • molecular mechanism of virus entry
  • development of virus entry inhibitors
  • vaccine development
  • host immune responses
  • B-cell immunity
  • structure-based immunogen design
  • vector and platform development for antigen delivery
  • HIV-1, SARS-CoV, PRRSV, and Influenza
Honors & Awards  
  • Honors at Entrance, Whitman College (1983)
  • Whitman College Scholarship (1983-1987)
  • Research Fellowship Award. The Northwest College and University Association for Science (1986, 1987)
  • Graduate Student Fellowship Award. NATO Advanced Study Institute and EEC (1992)
  • Graduate Student Fellowship Award. American Society for Virology (1993)
  • Post-Doctoral Intramural Research Training Award. National Institutes of Health, (1994 to 1998)
  • Plaque of Appreciation for Plenary Lecture. Korean Society of Infectious Diseases. (Seoul, Korea; November 2002)
  • New Investigator Travel Scholarship. Keystone Symposia (Whistler, Canada; April 2004)
  • Plaque of Appreciation. Microbiological Society of Korea (2006)
  • Plaque of Appreciation. Korean Society for Microbiology and Biotechnology. (2007)
  • Ramsey Lecture. Iowa State University (2009)
  • Lloyd Chair in Biomedical Sciences, Iowa State University (2009 - 2014)
  • Plaque of Appreciation. Korean Society for Microbiology and Biotechnology (2011)
  • Plaque of Appreciation. Korean Ministry of Science, ICT and Future Planning (April 2016). Invited as a speaker for the ULTRA Program administered by KOFST.
Leadership/Committees/Council  
  • CWRU Medical Scientist Training Program (MD/PhD) Steering Committee (2004 - 2007)
  • Group Leader, Vaccine Working Group; CWRU Center for AIDS Research (2008 - 2009)
  • Chair, Graduate Curriculum Committee, College of Veterinary Medicine, ISU (2014 - 2016)
  • Biotechnology Council, ISU (2011 - 2014)
  • ISU, CVM, BMS Departmental P&T Committee (2010-present)
  • ISU, CVM, BMS Graduate Education and Research Committee (2013-2016)
  • Associate Chair, Interdepartmental Microbiology Graduate Program (2012-2014)
  • Chair and DOGE, Interdepartmental Microbiology Graduate Program (2014-2016)
  • ISU, CVM, International Committee (2016-Present)
  • ISU, CVM, BMS Governance Committee (2016-Present)
  • NIH Study Section:  HIV/AIDS Vaccines (VACC) Study Section Regular Member (2012 to 2018)
Memberships  
  1. American Society of Microbiology
  2. International AIDS Society
  3. American Society of Virology (Lifetime Member)
Selected Publications  

Complete List of Publications (NCBI)

  • Srivastava, V, L. Niu, K. S. Phadke, B. H. Bellaire, M. W. Cho (2021). Induction of potent and durable neutralizing antibodies against SARS-CoV-2 using a receptor binding domain-based immunogen. Frontiers in Immunology. DOI: 10.3389/fimmu.2021.637982.
  • Niu, L., K. N. Wittrock, G. C. Clabaugh, V. Srivastava, M. W. Cho (2021). A structural landscape of neutralizing antibodies against SARS-CoV-2 receptor binding domain. Frontiers in Immunology. DOI: 10.3389/fimmu.2021.647934.
  • Pan, R., Y. Qin, M. Banasik, W. Lees, A. J. Shepherd, M. W. Cho, X.P. Kong (2018). Increased epitope complexity correlated with antibody affinity maturation and a novel binding mode revealed by structures of rabbit antibodies against the third variable loop (V3) of HIV-1 gp120. J. of Virology. JVI.01894-17. doi: 10.1128/JVI.01894-17.  Co-corresponding authorship.
  • Banerjee, S., H. Shi, M. Banasik, H. Moon, W. Lees, Y. Qin, A. Harley, A. Shepherd, and M. W. Cho (2017).  Evaluation of a novel multi-immunogen vaccine strategy for targeting 4E10/10E8 neutralizing epitopes on HIV-1 gp41 membrane proximal external region.  Virology 505: 113-126.
  • Banerjee S, Shi H, Habte H. H., Qin Y, M. W. Cho. (2016). Modulating immunogenic properties of HIV-1 gp41 membrane-proximal external region by destabilizing six-helix bundle structure. Virology 490:17-26. PMID: 26803471.
  • Habte H. H., S. Banerjee, H. Shi, Y. Qin, M. W. Cho. (2015). Immunogenic properties of a trimeric gp41-based immunogen containing an exposed membrane-proximal external region. Virology 486:187-197.  PMC4679429.
  • Qin Y., S. Banerjee, A. Agrawal, H. Shi, M. Banasik, F. Lin, K. Rohl, C. LaBranche, D. C. Montefiori, M. W. Cho. (2015). Characterization of a large panel of rabbit monoclonal antibodies against HIV-1 gp120 and isolation of novel neutralizing antibodies against the V3 loop. PLOS One. 10(6):e0128823.  PMCID: PMC4454676.
  • Qin Y., H. Shi, S. Banerjee, A. Agrawal, M. Banasik, M. W. Cho (2014). Detailed characterization of antibody responses against HIV-1 group M consensus gp120 in rabbits.  Retrovirology. 11: 125.  PMID: 25527085.
  • Qin, Y, M.B. Banasik, S. Kim, A. Penn-Nicholson, H.H. Habte, C. Labranche, D.C. Montefiori, C. Wang, M. W. Cho. 2014. Eliciting Neutralizing Antibodies with gp120 Outer Domain Constructs Based on M-Group Consensus Sequence.  Virology.  462-463: 363-376. PMCID: PMC4125429.
  • Penn-Nicholson, A., D. P. Han, S. J. Kim, H. Park, R. Ansari, D. C. Montefiori, and M. W. Cho (2008). Assessment of antibody responses against gp41 in HIV-1-infected patients using soluble gp41 fusion proteins and peptides derived from M group consensus envelope.  Virology.  372: 442-56.  PMCID: PMC2293309.