Michael Cho

2008 Vet Med
Education & Certifications  
  • BA, Biology and Chemistry, 1987, Whitman College, Walla Walla, Washington
  • PhD, Cellular, Viral and Molecular Biology, 1994, University of Utah, School of Medicine, Salt Lake City, Utah

  • 2017                                   Instructor-in-charge, BMS502, Methods in Biomedical Sciences

  • 2015-2017                          Instructor-in-charge, BMS599, Creative Component

  • 2015-2016                          Instructor-in-charge, TOX502, Toxicology Methods

  • 2013, 2011                          Instructor-in-charge, BBMB615, Molecular Immunology

  • 2011-2016                          Instructor-in-charge, VMPM520, Medical Immunology

  • 2010-2011                          Instructor-in-charge, BCB 699, Graduate Research

  • 2010-2017                          Instructor-in-charge, GENET 699, Graduate Research

  • 2010-2016                          Instructor-in-charge, MCDB 699, Graduate Research

  • 2010-2016                          Instructor-in-charge, TOX 699, Graduate Research

  • 2008, 2005                          Instructor-in-charge, Anthropology 323/423, AIDS: Epidemiology, Biology, and Culture

  • 2008, 2007, 2006                Instructor-in-charge, MVIR445, Introduction to Virology

  • 2005, 2004                          Instructor-in-charge, MBIO521, HIV & AIDS Research and Care

  • 2004, 2002                          Instructor-in-charge, MVIR445, RNA & DNA Viruses

  • 2009, 2006, 2003                Instructor-in-charge, MVIR466, Virus-Host Cell Interactions
Research Focus & Interests  

  • Structure-function of viral envelope glycoproteins
  • virus-host interactions
  • molecular mechanism of virus entry
  • development of virus entry inhibitors
  • vaccine development
  • host immune responses
  • B-cell immunity
  • structure-based immunogen design
  • vector and platform development for antigen delivery
  • HIV-1, SARS-CoV, PRRSV, and Influenza


Honors & Awards  
  • Tony Schauer Scholarship for Scholastic Excellence (1983)
  • Honors at Entrance, Whitman College (1983)
  • Whitman College Scholarship (1983-1987)
  • Research Fellowship Award. The Northwest College and University Association for Science (1986)
  • Research Fellowship Award. The Northwest College and University Association for Science (1987)
  • National Research Service Award. Department of Health and Human Services. NIH Genetics Pre-doctoral Training Grant (1991 to 1992). Relinquished because of change of academic institution by thesis advisor.
  • Graduate Student Fellowship Award. NATO Advanced Study Institute and EEC (1992)
  • Graduate Student Fellowship Award. American Society for Virology (1993)
  • Post-Doctoral Intramural Research Training Award. National Institutes of Health, (1994 to 1998)
  • Certificate of Appreciation for Public Service. Korean-American Association of the State of Maryland (1995)
  • Plaque of Appreciation for Plenary Lecture. Korean Society of Infectious Diseases. (Seoul, Korea; November 2002)
  • New Investigator Travel Scholarship. Keystone Symposia (Whistler, Canada; April 2004)
  • Plaque of Appreciation. Microbiological Society of Korea (2006)
  • Plaque of Appreciation. Korean Society for Microbiology and Biotechnology. (2007)
  • Ramsey Lecture. Iowa State University (2009)
  • Lloyd Chair in Biomedical Sciences, Iowa State University (2009 - Present)
  • Plaque of Appreciation. Korean Society for Microbiology and Biotechnology (2011)
  • Plaque of Appreciation. Korean Ministry of Science, ICT and Future Planning (April 2016). Invited as a speaker for the ULTRA Program administered by KOFST.
  • Cell and Gene Therapy Facility Quality Assurance Oversigh Board, CWRU Center for Stem Cell and Regenerative Medicine (2004 - 2009)
  • CRU Biomedical Sciences Training Program (PhD) Admission Committee (2004).
  • CWRU Medical Scientist Training Program (MD/PhD) Steering Committee (2004 - 2007).
  • CWRU Biomedical Graduate Student Symposium Poster Judging Committee (2004, 2008).
  • Group Leader, Vaccine Working Group; CWRU Center for AIDS Research (2008 - 2009).
  • Subcommittee on “Animal and Plant Diseases Impacting Humans” for the One Health Symposium at Iowa State University (2010).
  • Graduate Curriculum Committee, College of Veterinary Medicine, ISU (2010 - 2013).
  • Chair, Graduate Curriculum Committee, College of Veterinary Medicine, ISU (2014 - 2016). 
  • Biotechnology Council, ISU (2011 - 2014).
  • ISU, CVM, BMS Departmental P&T Committee (2010-2013).
  • ISU, CVM, BMS Departmental Chair Search Committee (2011).
  • CVM Presidential Initiative Faculty Search Committee (2013-2014).
  • ISU, CVM, BMS Graduate Education and Research Committee (2013-Present).
  • Associate Chair, Interdepartmental Microbiology Graduate Program (2012-2014).
  • Chair and DOGE, Interdepartmental Microbiology Graduate Program (2014-2016).
  • ISU, CVM, International Committee (2016-Present).
  • ISU, CVM, BMS Governance Committee (2016-Present).
  1. American Society of Microbiology
  2. International AIDS Society
  3. American Society of Virology (Lifetime Member)
Selected Publications  

NCBI Library

  1. McCusker, K., B. Braaten, M. W. Cho and D. Low (1991). Legionella pneumophila Inhibits, Protein Synthesis in Chinese Hamster Ovary Cells. Infection and Immunity 59: 240-246.

  2. Cho, M. W. and E. Ehrenfeld. (1991). Rapid Completion of the Replication Cycle of Hepatitis, A Virus Subsequent to Reversal of Guanidine Inhibition. Virology 180: 770-780.

  3. Cho, M. W., O. Richards, T. Dmitrieva, V. Agol and E. Ehrenfeld (1993). RNA Duplex, Unwinding Activity of Poliovirus RNA-Dependent RNA polymerase, 3Dpol. Journal of Virology 67: 3010-3018.

  4. Cho, M. W., N. Teterina, D. Egger, K. Bienz and E. Ehrenfeld (1994). Membrane Rearrangement and Vesicle Induction by Recombinant Poliovirus 2C and 2BC in Human Cells. Virology 202: 129-145.

  5. Teterina, N., W. Zhou, M. W. Cho and E. Ehrenfeld (1995). Inefficient Complementation Activity of Poliovirus 2C and 3D Proteins for Rescue of Lethal Mutations. Journal of Virology 69: 4245-4254.

  6. Shibata, R., C. Siemon, M. W. Cho, L. O. Arthur, S. M. Nigida Jr., T. Matthews, L. A. Sawyer, A. Schultz, K.K. Murthy, Z. Israel, A. Javadian, P. Frost, R. C. Kennedy, H. C. Lane, and M. A. Martin. (1996). Resistance of Previously Infected Chimpanzees to Successive Challenges with a Heterologous Intraclade B Strain of HIV-1. Journal of Virology 70: 4361-4369.

  7. Kashanchi, F., S. Khleif, J. Duvall, R. Sadaie, M. Radonovich, M. W. Cho, M. Martin, S. Chen, R. Weinmann and J. Brady. (1996). Interaction of Human Immunodeficiency Virus Type 1 Tat with a Unique Site of TFIID Inhibits Negative Cofactor Dr1 and Stabilizes the TFIID-TFIIA Complex. Journal of Virology 70: 5503-5510.

  8. Willey, R.L, R. Shibata, E. O. Freed, M. W. Cho and M. A. Martin. (1996). Differential Glycosylation, Virion-Incorporation and Sensitivity to Neutralizing Antibodies of HIV-1 Envelope Produced from Infected Primary T-Lymphocyte and Macrophage Cultures. Journal of Virology 70: 6431-6436.

  9. Cho, M. W., R. Shibata and M. A. Martin. (1996). Infection of Chimpanzee PBMC by HIV-1 Requires Cooperative Interaction Between Multiple Variable Regions of gp120. Journal of Virology 70: 7318-7321.

  10. Cho, M. W., M. K. Lee, M. C. Carney, J. F. Berson, R. W. Doms and M. A. Martin. (1998). Identification of gp120 determinants on a dual tropic human immunodeficiency virus type 1 that confers usage of CXCR4. Journal of Virology 72: 2509-2515. PMCID: PMC109554.

  11. Huang, M., R. Zensen, M. W. Cho and M. A. Martin. (1998). Construction and characterization of a temperature sensitive human immunodeficiency virus type 1 reverse transcriptase mutant. Journal of Virology 72: 2047-2054.

  12. Shibata, R., T. Igarashi, N. Haigwood, A. Buckler-White, R. Ogert, W. Ross, R. Willey, M. W. Cho, M. A. Martin (1999). Neutralizing antibody directed against the HIV-1 envelope glycoprotein can completely block HIV-1/SIV chimeric virus infections of macaque monkeys. Nature Med. 5: 204-210. PMID: 9930869

  13. Lee, M. K., J. Heaton, and M. W. Cho (1999). Identification of determinants of interaction between CXCR4 and gp120 of a dual-tropic HIV-1DH12 isolate. Virology 257: 290-296. PMID: 10826483

  14. Lee, M. K., M. A. Martin, and M. W. Cho (2000). Higher Western blot immunoreactivity of gp120 from R5 HIV-1 isolates compared to X4 or X4R5 isolates. AIDS Res. and Human Retroviruses. 16: 765-775.

  15. Tsunetsugu-Yokota, Y., T. Kato, S. Yasuda, Z. Matsuda, Y. Suzuki, Y. Koyanagi, N. Yamamoto, K. Akagawa, M. W. Cho, and T. Takemori. (2000). Transcriptional regulation of HIV-1 LTR during antigen-dependent activation of primary T cells by dendritic cells. J Leukoc Biol. 67:432- 40.

  16. Cho, M. W., M. K. Lee, C. H. Chen, T. Matthews, and M. A. Martin. (2000). Identification of gp120 regions targeted by a highly potent neutralizing antiserum elicited in a chimpanzee inoculated with a primary human immunodeficiency virus type 1 isolate. Journal of Virology. 74:9749-9754. PMCID: PMC112409.

  17. Hu, Y-C., J. Kaufman, M. W. Cho, H. Golding, and J. Shiloach (2000). Production of HIV-1 gp120 in packed-bed bioreactor using the vaccinia virus/T7 expression system. Biotechnology Progress. 16: 744-750.

  18. Cho, M. W., Y. B. Kim, M. K. Lee, K. C. Gupta, et al. (2001). Polyvalent envelope glycoprotein vaccine elicits a broader neutralizing antibody response but is unable to provide sterilizing protection against heterologous simian/human immunodeficiency virus infection in pigtailed macaques. Journal of Virology. 75: 2224-2234. PMCID: PMC114806.

  19. Ogert, R. A., M. K. Lee, W. Ross, A. Buckler-White, M. A. Martin, M. W. Cho (2001). N- linked glycosylation sites adjacent to and within the V1/V2 and the V3 loops of dualtropic human immunodeficiency virus type 1 isolate DH12 gp120 affect coreceptors usage and cellular tropism. Journal of Virology. 75: 5998-6006. PMCID: PMC114315.

  20. Kim, Y. B., M. K. Lee, D. P. Han, and M. W. Cho (2001). Development of a safe and rapid virus neutralization assay using MuLV pseudotyped with HIV-1 envelope glycoprotein. AIDS Res. and Human Retroviruses. 17: 1715-1724. PMID: 12504547.