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It is very important to understand the mode of action of drugs (pharmacology). My teaching focuses on those drugs that acts on ion-channels and includes the action of cardiac drugs, drugs that act on nematode parasites, with classes for neuroscience and toxicology graduate students and DVM students.
We are interested in molecular and cellular pharmacology with a focus on drugs that act on ion-channels of nematodes, including those parasites that cause disease in humans in the developing world and in animals.
Our work is supported by NIH and NSF and involves molecular, cellular, pharmacological, electrophysiological, Xenopus expression and microfluidic techniques to study the effects of drugs like emodepside, pyrantel, derquantel and ivermectin on a range of membrane ion-channels. We study a range of nematodes including, C. elegans, Brugia malayi, Ascaris suum, Oesophagostomum dentatum and Haemonchus contortus. We encourage potential graduate students and post-doctoral researchers to contact us if they are interested in our research.
· 1997: D.Sc., University of Edinburgh
· 1998: Personal Chair, Edinburgh University,
· 2002 –2003: NIH, NIAID Study Section Member: TMP, Tropical Medicine Parasitology Federal Research review body
· 2004-8: NIH, NIAID Study Section Member: PTHE, Pathogenic Eukaryotes, Federal Research review body
· 2007 American Society of Parasitology Bueding and von Brand Lectureship (For Outstanding Scientific contributions to parasite biochemistry and pharmacology).
· 2008 NIH, NIAID Study Section ad hoc DDR, Drug Development and Resistance, Federal Research review body
· 2009 Ad hoc Challenge Grants RFA-OD-09-003 NIH/NIAID
2009- Member NIH College of CSR Reviewers
· 2010 K22 Ad hoc K22 NIH/NIAID
· 2012 SBIR Grant ZRG1 NIH/NIAID
· Ad hoc Study section NIH NIAID’s Microbiology and Infectious Diseases B Subcommittee (MID-B).
· Ad hoc Study section NIH Special Emphasis Panel, Pathogenic Eukaryotes (PTHE)
1. Member of the Physiological Society.
2. Member of the British Pharmacological Society.
3. Member of the Royal College of Veterinary Surgeons (MRCVS)
4. Member of the British Society of Parasitology
5. Diplomate of the European College for Veterinary Pharmacology and Therapeutics (ECVPT)
6. American Association of Veterinary Parasitology
7. American Society of Veterinary Parasitology
8. Society for Toxicology