Steve Carlson

D.V.M., Ph.D.
Associate Professor
515-294-0912
2028 Vet Med
Education & Certifications  
  • B.S., Animal Science, 1986, Iowa State University
  • D.V.M., Veterinary Medicine, 1990, Iowa State University
  • Ph.D., Pharmacology, 1997, University of Iowa
  • Postdoctoral training: Microbiology, 1998, University of Iowa
Teaching  
  • 2007-present      BMS 354 Drug Metabolism, Pharmacogenomics, NSAIDS, Anti-coagulants,Autacoids, and Antihistamines (7 lectures)
  • 2007-present      BMS 443 Antibacterials, Antifungals, Antivirals, Nutraceuticals, Adverse Drug Reactions, Respiratory Pharmacology, and Drug-Drug Interactions (14 lectures)
  • 2008-present      VMPM 386 Salmonella (1 lecture)
  • 2012-present      BMS688 Research Review (16 lectures)
  • 2013-present      BMS 538 Muscle and Reproductive Physiology (5 lectures)
  • 2014-present      BMS 334 Reproductive Physiology (8 lectures)
  • 2009-13              BMS 353 Receptors and Disease, Molecular Medicine, and Molecular Diagnostics (8 lectures)
  • 2009-12              BMS 335 Genetics, Gene Expression, Cytoskeleton, and Glycocalyx (4 lectures)
  • 2009-11              VMPM 537 Salmonella (1 lecture)
Research Focus & Interests  

Investigations of the molecular pharmacologic aspects of the relationships between receptors, antibiotics, antibiotic resistance, and the virulence of bacterial enteropathogens such as Salmonella.

Honors & Awards  
  • SCAVMA Basic Sciences Outstanding Teaching Award Winner 2016

  • SCAVMA Basic Sciences Outstanding Teaching Award Winner 2010

  • Zoetis Distinguished Teaching Award Winner 2016
Memberships  
  1. American Association for the Advancement of Science

  2. American Society for Microbiology

Selected Publications  

 Link to PubMed

1.         Carlson, S. A., Chatterjee, T. K. and Fisher, R. A.  Lack of constitutive activation or inactivation of the platelet‑activating factor receptor by glutamate substitution of alanine 230.  Recept.  Sign. Transd.  6:111‑120.  1996.

2.         Carlson, S. A., Chatterjee, T.K. and Fisher, R.A.  The third intracellular domain of the platelet‑activating factor receptor is a critical determinant in receptor coupling to phosphoinositide phospholipase C‑activating G proteins:  Studies using intracellular domain minigenes and receptor chimeras.  J. Biol. Chem.  271 (38):23146‑53.  1996.

3.         Carlson, S. A.  Identification of molecular determinants of platelet‑activating factor receptor coupling to phosphoinositide phospholipase C‑activating G proteins.  University of Iowa.  270 pp.  1997.  (Thesis)

4.         Carlson, S. A., Chatterjee, T. K., Murphy, K. P. and Fisher, R. A.  Mutation of a putative amphipathic alpha‑ helix in the third intracellular domain of the platelet‑activating factor receptor disrupts receptor/G protein coupling and signaling.  Mol. Pharmacol.  53:451‑458.  1998.

5.          Carlson, S. A. and Jones, B. D.  Inhibition of Salmonella typhimurium invasion by host cell expression of secreted bacterial invasion proteins.  Infect. Immun.  66 (11):5295‑5300.  1998.

6.         Carlson, S. A., Bolton, L. F., Briggs, C. E., Hurd, H. S., Sharma, V. K., Fedorka‑Cray, P. J. and Jones, B. D.  Detection of multiresistant Salmonella typhimurium DT104 using multiplex and fluorogenic PCR.  Mol. Cell. Probes  13 (3):213‑22.  1999.

7.        Carlson, S. A., Browning, M., Ferris, K. E. and Jones, B. D.  Identification of diminished tissue culture invasiveness among multiple antibiotic resistant Salmonella typhimurium DT104.  Microb. Pathog.  28 (1):37‑44.  2000.

8.        Carlson, S. A. and Ferris, K. E.  Augmentation of antibiotic resistance in Salmonella typhimurium DT104 following exposure to penicillin derivatives.  Vet. Microbiol.  73 (1):25‑35.  2000.

9.        Carlson, S. A., Willson, R.M., Crane, A.J. and Ferris, K.E.  Evaluation of invasion‑conferring genotypes and antibiotic‑induced hyperinvasive phenotypes in multiple antibiotic resistant Salmonella typhimurium DT104.  Microb. Pathog.  28 (6):373‑378.  2000.

10.      Sharma, V. K. and Carlson, S. A.  Simultaneous detection of Salmonella strains and Escherichia coli O157:H7 with fluorogenic PCR and single‑enrichment‑broth culture.  Appl. Environ. Microbiol.  66 (12):5472‑5476.  2000.

11.      Frana, T. S. and Carlson, S. A.  Development and use of a plasmid encoding green fluorescent protein in multiple antibiotic‑resistant Salmonella.  Biotechniques.  30 (1):28‑32.  2001.

12.      Frana, T. S., Carlson, S. A. and Griffith, R. W.  Relative distribution and conservation of genes encoding aminoglycoside‑modifying enzymes in Salmonella enterica serotype Typhimurium phage type DT104.  Appl. Environ. Microbiol.  67 (1):445‑448.  2001.

13.      Carlson, S. A., et al.  Antibiotic resistance in Salmonella enterica serovar Typhimurium exposed to microcin‑producing Escherichia coli.  Appl. Environ. Microbiol.  67 (8):3763‑3766.  2001.

14.      Carlson, S. A., et al.  Secretion of a putative cytotoxin in multiple antibiotic resistant Salmonella enterica serotype Typhimurium phagetype DT104.  Microb. Pathog.  31 (4):201‑204.  2001.

15.      Carlson, S. A., Omary, M.B. and Jones, B.D.  Identification of cytokeratins as accessory mediators of Salmonella entry into eukaryotic cells.  Life Sci.  70 (12):1415‑1426.  2002.

16.      Carlson, S. A., et al.  Abomasitis associated with multiple antibiotic resistant Salmonella enterica seroptype Typhimurium phagetype DT104.  Vet. Microbiol.  85 (3):233‑240.  2002.

17.      Wu, M. T., Carlson, S. A. and Meyerholz, D. K.  Cytopathic effects observed upon expression of a repressed collagenase gene present in Salmonella and related pathogens:  mimicry of a cytotoxin from multiple antibiotic‑resistant Salmonella enterica serotype Typhimurium phagetype DT104.   Microb. Pathog.  32:1‑9. 2002.

18.      Carlson, S.A., Casey, T.A., Wu, M.T., et al. A high‑throughput genetic system for assessing the inhibition of proteins:  identification of antibiotic resistance and virulence targets and their cognate inhibitors in Salmonella.  Analyt. Biochem.  310 (1):72‑83.  2002.

19.      Meyerholz, D. K., Stabel, T. J., Ackermann, M. R., Carlson, S. A., Jones, B. D. and Pohlenz, J.  Early epithelial invasion by Salmonella enterica serovar Typhimurium DT104 in the swine ileum. Vet. Pathol. 39:712‑20.  2002.

20.      Carlson, S. A., Wu, M. T. and Frana, T. S.  Multiple antibiotic resistance and virulence of Salmonella enterica serotype Typhimurium phagetype DT104.  In: Current Topics in Food Safety in Animal Agriculture, Isaacson, R. E. and Torrence, M. E. (eds.).  ISU Press, Ames, IA., pgs. 123-29.

21.      Carlson, S. A. and Wu, M. T.  Avoidance of false negative PCR in the integron-retron junction in multiple antibiotic resistant Salmonella enterica serotype Typhimurium.  Mol. Cell. Probes 17(4):183-186. 2003.

22.      Ellingson, J. L. E., Anderson, J. L., Carlson, S. A. and Sharma, V. K. Twelve hour PCR technique for the sensitive, specific detection of Salmonella species in raw and ready to eat meat products. Mol. Cell. Probes, 18(1):51-57. 2004.

23.      Frana, T. S., Carlson, S. A., et al.  Effects of microcin 24-producing E. coli on Salmonella shedding and antibiotic resistance in swine.  Amer. J. Vet. Res., 65(12):1616-1620. 2004.

24.       Carlson, S.A., Wu, M., et al. SlyA regulates the collagenase-mediated cytopathic phenotype in multiresistant Salmonella.  Microb. Pathogen., 38(4):181-7.  2005.

25.      Ellingson, J.L.E., Koziczkowski, J. J., Anderson, J. L., Carlson, S. A., and Sharma, V. K. Rapid PCR detection of enterohemorrhagic Escherichia coli (EHEC) in bovine food products and feces Mol. Cell. Probes, 19:213-7.  2005.

26.      Sharma, V. K., Carlson, S. A., Casey, T. C.  Hyperadherence of an hha mutant of Escherichia coli O157:H7 is correlated with enhanced expression of LEE-encoded adherence genes.  FEMS Microbiol. Lett., 243(1):189-196.  2005.

27.      Rasmussen, M.A., Carlson, S. A., Franklin, S.K., Wu, M.T. and McCuddin, Z.P.  Exposure to rumen protozoa leads to enhancement of pathogenicity and invasion by multiple-antibiotic-resistant Salmonella bearing SGI1Inf. Immun., 73:4668-75.  2005.

28.      McCuddin, Z. P., Carlson, S. A., Rasmussen, M. and Franklin, S.  Klebsiella to Salmonella gene transfer within rumen protozoa.  Vet. Microbiol., 114(3-4):275-284.  2006.

29.      Carlson, S. A., Sharma, V. K., McCuddin, Z. P., Rasmussen, M. A., and Franklin, S. K.  Involvement of a Salmonella genomic island 1 gene in the rumen protozoan-mediated enhancement of invasion for multiple-antibiotic-resistant Salmonella enterica serovar Typhimurium.  Infect Immun. 75(2):792-800.  2007. 

30.      Carlson, S. A., Rasmussen, M. A., and Franklin, S. K.  Free-living and host-associated protozoa as training camps for intracellular pathogens.   In: Virulence Mechanisms of Bacterial Pathogens, Brogden et al. (eds.).  ASM Press, Washington, DC., pgs. 117-32.  2007.

31.      McCuddin ZP, Carlson SA, Sharma VK. Experimental reproduction of bovine Salmonella encephalopathy using a norepinephrine-based stress model.  Vet J. 175(1):82-8.  2008.

32.       Patton, TG, Sharma, VK, Carlson SA. Evaluation of the control of pathogen load by an anti-Salmonella bacterium in a herd of cattle with persistent Salmonella infection, Amer J. Vet. Res., 70(1):92-8.  2009.

33.   Patton, TG, Scupham A, Bearson, SM, and Carlson SA. Characterization of fecal microbiota from a Salmonella endemic cattle herd as determined by oligonucleotide fingerprinting of rDNA genes  Vet. Microbiol. 136(3-4):285-92.  2009.

34.      N. Xiong, M. Brewer, T. A. Day, M. J. Kimber, A. E. Barnhill, S. A. Carlson, Comparisons of Novel Salmonella Virulence Phenotypes Observed in Cattle and Swine, Amer. J. Vet. Res, 2010, 71(10):1170-7.

35.       A. E. Barnhill, K. E. Weeks, N. Xiong, T. A. Day, S. A. Carlson. Identification of multiresistant Salmonella capable of subsisting on antibiotics, Appl. Environ. Microbiol., 2010, 76(8):2678-2680.

36.      Michelle M. Rutz-Mendicino Elizabeth M. Snella, Jackie K. Jens, Steven A. Carlson, Markus H. Kuehn, Gillian J. McLellan, N. Matthew Ellinwood, The Identification And Removal Of Potentially Confounding Phenotypes From A Siamese-Derived Feline Glaucoma Breeding Colony, Comp Lab Animal Med, 2011, 61:251-7.

37.       Ogunleye, A., and Carlson, SA, Survey of 3rd generation cephalosporin genes in multi-resistant Salmonella serotypes form septic poultry and an asymptomatic healthy pig from Nigeria, Afr. J. Microbiol. Res., 2011, 5(15):2139-2144.

38.      Zamanian, M., Michael J Kimber, Paul McVeigh, Aaron G Maule, Steve A Carlson, Tim A Day, The repertoire of G protein-coupled receptors in the human parasite Schistosoma mansoni and the model organism, Schmidtea mediterranea; BMC Genomics, 2011, 12:596.

39.      AE Barnhill, E Novohilzhova, TA Day, and SA Carlson, Schistosoma-associated Salmonella resist antibiotics via specific fimbrial attachments to the flatworm, Parasites & Vectors, 2011, 4:128.

40.      Sakai, M., SA Carlson, J. Noxon, Oral pharmacokinetics of terbenafine after single-dose administration in the dog, Veterinary Dermatology, 2011, 22:528-34.

41.      Xiong N, Brewer MT, Anderson KL, Watrous GK, Weeks KE, Barnhill AE, Day TA, Kimber MJ, Carlson SABeta-lactam antibiotics prevent Salmonella-mediated bovine encephalopathy regardless of the β-lactam resistance status of the bacteria. Vet J. 2011 Jul 26.

42.      Xiong N, Brewer MT, Anderson KL, Weeks KE, Carlson SAExpression of a collagenase that enables blood-brain barrier penetration for Salmonella implicated in bovine encephalopathies. Microb Pathog. 2011 Sep;51(3):230-2.

43.      Brewer MT, Xiong N, Dier JD, Anderson KL, Rasmussen MA, Franklin SK, Carlson SAComparisons of Salmonella conjugation and virulence gene hyperexpression mediated by rumen protozoa from domestic and exotic ruminants. Vet Microbiol. 2011 Aug 5;151(3-4):301-6.

44.      Ogunleye, AO and Carlson, SA.  Emergence of an SGI1-bearing Salmonella enterica serotype Kentucky isolated from septic poultry in Nigeria.  J. Inf in Developing Countries, 2011, 6(06), 483-488.

45.      Barnhill, A., Brewer, M., Carlson, S., 2012. Adverse Effects of Antimicrobials via Predictable or Idiosyncratic Inhibition of Host Mitochondrial Components. Antimicrob Agents Chemother. 56, 4046-4051.

46.      Barnhill, AE, Griffith, R. W., and Carlson, S. A.  Salmonellosis.  In: Diseases of Swine, 10th Edition, Zimmerman et al. (eds.).  Wiley-Blackwell, Ames, IA, pgs. 821-833.

47.      Xiong, N., Brewer, M., Anderson, K., Carlson, S., 2013. Non-typhoidal Salmonella encephalopathy involving lipopolysaccharide in cattle. Vet Microbiol. 162, 285-287.

48.      Agbedanu, PN, Brewer, MT, Kimber, MJ, Anderson, KL, Rasmussen, SK, Rasmussen, MA, and Carlson, SA., 2013.  Involvement of a putative intercellular signal-recognizing G protein-coupled receptor in the engulfment of Salmonella by the protozoan Tetrahymena.  Open Vet J.  3(2):69-74.

49.      Stock, M., K. Fiedler, S. Acharya, J. Lange, G. Mlynarczyk, S. Anderson, G. McCormack, S. Kanuri, N. Kondru, M. Brewer, and S. Carlson. 2013. Antibiotics acting as neuroprotectants via mechanisms independent of their anti-infective activities. Neuropharmacology. 73:174-182.

50.      M. Brewer, Xiong N, K. Anderson, and S. Carlson. Effects of subtherapeutic concentrations of antimicrobials on gene acquisition events in Yersinia, Proteus, Shigella, and Salmonella recipient organisms in isolated ligated intestinal loops of swine. Am J Vet Res 74:1078-1083 (2013).

51.      M. Brewer, P. Agbedanu, M. Zamanian, T. Day, and S. Carlson. Evidence for a bacterial lipopolysaccharide-recognizing G-protein-coupled receptor in the bacterial engulfment by Entamoeba histolytica. Eukaryot Cell. 12:1433-1438 (2013).

52.      Martin, RJ, Hsu, WH., and Carlson, S. A.  Principles of Drug Absorption, Drug Disposition and Drug Action.  In: Handbook of Veterinary Pharmacology, 2nd Edition, Walter H. Hsu. (ed.).  Shinilbooks, Seoul, Republic of South Korea, pgs. 1-36.

53.      Carlson, S. A., Coetzee, JF, and Hsu, WH.  Antimicrobial Drugs.  In: Handbook of Veterinary Pharmacology, 2nd Edition, Walter H. Hsu. (ed.).  Shinilbooks, Seoul, Republic of South Korea, pgs. 471-510.

54.      Ogunleye, AO and Carlson, SA.  Characterization of Salmonella enterica Ituri isolated from diseased poultry in Nigeria.  African J  Biotechn, 2013, 6(06), 483-488.

55.      Pepin, B., et al., Carlson, SA, Survey of canine monogenetic diseases with established molecular bases, Vet Sci & Animal Husbandry, 2014, 1(1):7.

56.      Mlynarczyk G, et al., Carlson SA, Salmonella as a biological "Trojan horse" for neoplasia: Future possibilities including brain cancer. Med Hypotheses. 2014; 83: 342-345.

57.      Anderson, K.L. and Carlson, S.A.  New perspectives on mitigating Salmonella in cattle.  Bovine Vet., in press.

58.      SK Olsen & SA Carlson, In vitro bactericidal activity of aminoglycosides, including the next-generation drug plazomicin, against Brucella spp., Intl. J. Antimicrob. Agents, 2015, 45(1), 76-8.

59.      Anderson, K.L., Agbedanu, P.N., Brewer, M.T., and Carlson, S.A.  Doxycycline as an inhibitor of p-glycoprotein in the alpaca; maintaining avermectins in the CNS during treatment for meningo-helmointhiasis.  Vet Parasit., 2015 Sep 15;212(3-4):303-7.      

60.      Withrock, I.,…… SA Carlson, Genetic disorders conferring resistance to infectious diseases, Genes and Diseases, 2015, Volume 2, Issue 3, September 2015, Pages 247-254.

61.      Kristi L. Anderson, Matthew T. Brewer, Mark A. Rasmussen, Steve A. Carlson., Identification of heritage breeds of chickens that resist colonization by Salmonella, Livestock Sci., Volume 182, December 2015, Pages 34-37.

62.      Anderson, S, et al., and Carlson SA, Under-Appreciated Off-Target Drug Effects Resulting in Altered Gene Expression Events with Epigenetic and Quasi-Epigenetic Bases, 2016, Pharmacologic Reviews, 107:229-233.

63.      Feye, K., K. Anderson, M. Scott, D. Henry, K. Dorton, B. Depenbusch and S. Carlson (2016). "Abrogation of Salmonella and E. coli O157:H7 in Feedlot Cattle Fed a Proprietary Saccharomyces cerevisiae Fermentation Prototype." J of Veterinary Science & Technology 7:350.

63.      Whittaker, J., Carlson, SA, Jones, D, and Brewer, MT, Molecular mechanisms for anthelmintic resistance in strongyle nematode parasites of veterinary importance, Veterinary Pharmacology and Therapeutics, doi: 10.1111/jvp.12330, 2016.

64.      Feye, K., Anderson, K., Scott, M, McIntyre, D., Carlson, SA., Inhibition of the virulence, antibiotic resistance, intestinal colonization, and fecal shedding of multiple antibiotic-resistant Salmonella Typhimurium in broilers fed Original XPC, Poultry Sci, 10.3382.

65.      Brine, C., Agbedanu, P., Juelsgaard, R., Carlson, S., and Brewer, M.  Aberrant migration of Dirofilaria immitis in the peritoneum of a dog, Vet Record Case Reports, 4:1 e000335, 2016.

66.       Whittaker, J., Robertson, AP, Kimber, MK, Day, TD, Carlson, SA., Intestinal Enterobacteriaceae that Protect Nematodes from the Effects of Benzimidazoles, J. Bacteriology and Parasitology, in press.

Under review:

K. Feye., K. Anderson, J. Carroll, M. Scott, S. Reeves, D. McIntyre, I. Yoon, and S. Carlson, Mechanisms Underlying the anti-Salmonella Effects of Yeast Fermentates in Livestock Feed, J of Veterinary Science & Technology, in preparation.

In preparation:

Day,T., Carlson, SA., Identification of cattle that naturally resist Salmonella, submitted to Livestock Sci.

K. Feye., K. Anderson, J. Carroll, D. Smith, H. Pavlidis, D. McIntyre, and S. Carlson, Inhibition of the Load, Prevalence, Virulence, and Antibiotic Resistance of Salmonella in Commercial Broilers and Turkeys Fed XPCTM, J. Food Protection, in preparation.

K. Feye., K. Anderson, J. Carroll, D. McIntyre, and S. Carlson, Inhibition of the Load, Prevalence, Virulence, and Antibiotic Resistance of APEC in Commercial Broilers and Turkeys Fed XPCTM, J. Food Protection, in preparation.

K. Feye., K. Anderson, J. Carroll, B. Stone, D. McIntyre, and S. Carlson, Inhibition of Various Aspects of Salmonella and E. coli O157:H7 in Dairy Cattle Fed NutriTekTM, J. Dairy Sci, in preparation.

V. Nserenko, S. Carlson, and M. Scott, Use of an IAMM Model to Predict the anti-Salmonella Effects of Yeast Fermentates.