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My current research is focused on neuroinflammation and disease modification in epileptogenesis and epilepsy. Since 1995, my basic science research has been focused on identifying neurobiological changes in rodent models of nerve injury and epilepsy. The core theme of my research has been the role of glial-neuronal communication in neuroprotection mediated by the nitric oxide-cGMP pathway. I lead two major projects as PI; nerve injury induced chronic neurodegeneration project from 2000-2012 and disease modification in epilepsy from 2005 to-date. Our recent papers, published in the Neurobiology of Disease (2016, 18; 93:184-200) and Frontiers in Bioscience (Elite Ed), 2016, 8: 390-411), demonstrate our skills in a variety of techniques that were developed in my laboratory to address the core issues in epilepsy research. As a project leader, I trained undergraduate, graduate students and postdoctoral fellows. Through collaboration, I utilized viral vector transduction technology, in vitro and in vivo, to investigate neuroprotective pathways in glia (Glia, 49: 197-210, 2005) and neurons (J Neurochem. 100:790-801, 2007). I mentored 17 graduate students (9 as Major Professor, and 8 as Co-Major Professor) and 36 Undergraduate Student Projects during my time in Liverpool, England. After moving to Iowa State University, I mentored 12 undergraduate students. I am currently mentoring two undergraduate students, one from McNair program, two graduate students, and two more graduate (PhD) students on rotation, and a Fulbright MS student (2 MS students completed in last two years).
Professional Society Membership
Peer Reviewer of Grant applications
External Examiner: (Professional courses and PhD)