B.V.Sc Shandong Agricultural University (China) 1983 Vet Medicine
M.S. National Inst. Veterinary Biologics (China) 1986 Vet Microbiology
Ph.D. Iowa State University 1994 Immunobiology
Postdoc University of Missouri-Columbia 1994-1997 Molecular Microbiology
Food safety; antibiotic resistance; bacterial pathogenesis; pathogen-host interactions; prevention and control of infectious diseases.
Endowed Frank K. Ramsey Chair in Veterinary Medicine, Iowa State University, 2003-2012 and 2017-2021
Pfizer Award for Research Excellence, Iowa State University, 2007
Fellow, American Academy of Microbiology, elected 2015
Honorary Diplomate, American College of Veterinary Microbiologists, elected 2017
Fellow, AAAS, elected 2018
VMPM Departmental Officer of Graduate Education
Chair, CVM International Development Committee
Chair, Research Advisory Committee
Associate Dean for Research and Graduate Studies
Chair, Division Z (Animal Health), American Society for Microbiology
Chair, USDA NC1202 Committee-Enteric Diseases of Food Animals: Enhanced Prevention, Control and Food Safety.
Council Member and President, CRWAD
American Society for Microbiology
Conference of Research Workers in Animal Diseases
American Association for the Advancement of Science
American Veterinary Medical Association
American Association of Avian Pathologists
Dai, L., O. Sahin, Y. Tang, and Q. Zhang. 2017. A mutator phenotype promoting the emergence of spontaneous oxidative stress resistant mutants in Campylobacter jejuni. Appl. Environ. Microbiol. 83: e01685-17.
Tang, Y., R. J. Meinersmann, O. Sahin, Z. Wu, L. Dai, J. Carlson, J. Plumblee, L. Genzlinger, J. T. LeJeunee, and Q. Zhang. 2017. Wide but variable distribution of a hypervirulent Campylobacter jejuni clone in beef and dairy cattle in the United States. Appl. Environ. Microbiol. 83: e01425-17 (featured in Spotlight).
Su, C.-C., L. Yin, N. Kumar, L. Dai, A. Radhakrishnan, J. R. Bolla, H.-T. Lei, T.-H. Chou, K. Rajashankar, Q. Zhang, Y.-K. Shin, and E. Yu. 2017 Structures and transport dynamics of the Campylobacter jejuni multidrug efflux pump CmeB. Nature Communications. 8: 171. DOI: 10.1038/s41467-017-00217z.
Tang, Y., L. Dai, O. Sahin, Z. Wu, M. Liu, and Q. Zhang. 2017. Emergence of a plasmid-borne multidrug resistance gene cfr(C) in foodborne pathogen Campylobacter. J. Antimicrob. Chemother. DOI:10.1093/jac/dkx023
Sahin, O., S. Terhorst, E. Burrough, Z. Shen, Z. Wu, L. Dai, Y. Tang, P. Plummer, J. Ji, M. Yaeger, and Q. Zhang. 2017. Key role of capsular polysaccharide in the induction of systemic infection and abortion by hypervirulent Campylobacter jejuni. Infect. Immun. vol. 85 no. 6 e00001-17.
Wu Z, Periaswamy B, Sahin O, M. Yaeger, P. Plummer, W. Zhai, Z. Shen, L. Dai, S. Chen, and Q. Zhang. 2016. Point mutations in the major outer membrane protein drive hypervirulence of a rapidly expanding clone of Campylobacter jejuni. Proc. Natl. Acad. Sci. U. S. A. 113: 10690-10695.
Yao, H., Z. Shen , Y. Wang, F. Deng, D. Liu, G. Naren, L. Dai, C. Su, B. Wang, S. Wang, C. Wu, E.W. Yu, Q. Zhang, and J. Shen. 2016. Emergence of a potent multidrug efflux pump variant that enhances Campylobacter resistance to multiple antibiotics. mBio 7:e01543-16. doi:10.1128/mBio.01543-16.
Shen Z., R.D. Patil, O. Sahin, Z. Wu, X.Y. Pu, L. Dai, P. J. Plummer, M. Yaeger, and Q Zhang. 2016. Identification and functional analysis of two toxin-antitoxin systems in Campylobacter jejuni. Mol Microbiol. 101: 909–923.
Dai, L., W. T Muraoka, Z. Wu, O. Sahin, and Q. Zhang. 2015. A single nucleotide change in mutY increases the emergence of antibiotic-resistant Campylobacter jejuni mutants. J. Antimicrob. Chemother. 70:2739-48; DOI:10.1093/jac/dkv190
Sahin, O., C. Fitzgerald, S. Stroika, S. Zhao, R. Sippy, P. Kwan, P. Plummer, J. Han, M. Yaeger, and Q. Zhang. 2012. Molecular Evidence for zoonotic transmission of an emergent highly pathogenic Campylobacter jejuni clone in the United States. J. Clin. Microbiol. 50(3):680-7.
Luangtongkum, T., Z. Shen, V. Seng, O. Sahin, B. Jeon, P. Liu, and Q. Zhang. 2012. Impaired fitness and transmission of macrolide-resistant Campylobacter jejuni in its natural host. Antimicrob. Agents Chemother. 56(3):1300-8.